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Protein Overview: grp-1

General Information:
Name(s) found: grp-1 / CE26942 [WormBase]
Description(s) found:
Found 20 descriptions.
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  • WBGene00001743 locus:grp-1 GTP exchange factor for ARFs 1 status:Confirmed UniProt:P34512 protein_id:CCD64454.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 393 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEALink to PubMed article]
    Biological Process: regulation of ARF protein signal transduction [IEALink to PubMed article]
    Molecular Function: ARF guanyl-nucleotide exchange factor activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSRYSERNG LSETEKMTLP KVRKRKAQLV DEIEALKNEV REVDEELDQV YYTHPKSKEY  60
   61 HKIVVNGRKK FNQDPWKALD WLASRNVVAK DPQALALWMK AGEGLSKSAI GEILGDNRPF 120
  121 ALETLDRFTK EHKLHDVPIV PALRQYLFSF RLPGESQKIN RILEKFAEVY ANQNPSYGNA 180
  181 DQAHTVAYSC IMVNTLLHNP NVKDKPSLEK YIEMNEQLLE KGAITIEQLT EVYESVSVTQ 240
  241 FKIPDEVSTS GKGTVNDILL HAEREGWLFK QSSNPLFSGA LSWKKRWFVL SENCLYYFDQ 300
  301 MTDKEPKGII TLANVGIRKV EAPSRPFMFE IFSLSDGQIK ACKTEQDGRL VEGRHSIYKI 360
  361 CAVNDEDMRS WINAISRMMA PQQHLLARPK STH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..246] PSI-BLAST 47.154902 SEC7 DOMAIN OF THE ARF EXCHANGE FACTOR ARNO WITH BREFELDIN A-SENSITIZING MUTATIONS
    2 View Details [247..393] PSI-BLAST 24.522879 Grp1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ARF guanyl-nucleotide exchange factor activity
    		•  3.21855719969171 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  2.34270596875878 bayes_pls_golite062009
  • GTPase regulator activity
    		•  2.33775275044058 bayes_pls_golite062009
  • enzyme regulator activity
    		•  2.18282128472415 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  2.13694141859871 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  1.9528150458215 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.93411052758697 bayes_pls_golite062009
  • protein binding
    		•  1.76037270569241 bayes_pls_golite062009
  • binding
    		•  1.27080459409383 bayes_pls_golite062009
  • signal transducer activity
    		•  0.329302915338046 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.329302915338046 bayes_pls_golite062009
  • phosphoinositide binding
    		•  0.0750646331148792 bayes_pls_golite062009
  • phospholipid binding
    		•  0.0172309833091902 bayes_pls_golite062009
    2
    Term Confidence Notes
  • protein binding
    		•  3.17213698546013 bayes_pls_golite062009
  • actin binding
    		•  3.00914116198279 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.67068028643471 bayes_pls_golite062009
  • binding
    		•  2.65091781683225 bayes_pls_golite062009
  • profilin binding
    		•  1.91751880819794 bayes_pls_golite062009
  • actin filament binding
    		•  1.90278181549871 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  1.3855488465667 bayes_pls_golite062009
  • transporter activity
    		•  1.28986800087234 bayes_pls_golite062009
  • protein domain specific binding
    		•  1.24896354314328 bayes_pls_golite062009
  • phospholipid binding
    		•  1.09683218092034 bayes_pls_golite062009
  • receptor binding
    		•  1.00859318603128 bayes_pls_golite062009
  • phosphoinositide binding
    		•  0.71817045430443 bayes_pls_golite062009
  • signal transducer activity
    		•  0.704817275989342 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.704817275989342 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.54401901869178 bayes_pls_golite062009
  • GTPase binding
    		•  0.18593284596663 bayes_pls_golite062009
  • lipid binding
    		•  0.179561240451969 bayes_pls_golite062009
  • protein complex binding
    		•  0.15504114076075 bayes_pls_golite062009
  • small GTPase binding
    		•  0.124515895045891 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle