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View Structure Prediction Details

Protein: grp-1
Organism: Caenorhabditis elegans
Length: 393 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for grp-1.

Description E-value Query
Range
Subject
Range
gi|109125469 - gi|109125469|ref|XP_001111690.1| PREDICTED: similar to pleckstrin homology, Sec7 and coiled/coil dom...
349.0 [0..7] [391..136]

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Predicted Domain #1
Region A:
Residues: [1-246]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSRYSERNG LSETEKMTLP KVRKRKAQLV DEIEALKNEV REVDEELDQV YYTHPKSKEY  60
   61 HKIVVNGRKK FNQDPWKALD WLASRNVVAK DPQALALWMK AGEGLSKSAI GEILGDNRPF 120
  121 ALETLDRFTK EHKLHDVPIV PALRQYLFSF RLPGESQKIN RILEKFAEVY ANQNPSYGNA 180
  181 DQAHTVAYSC IMVNTLLHNP NVKDKPSLEK YIEMNEQLLE KGAITIEQLT EVYESVSVTQ 240
  241 FKIPDE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 47.154902
Match: 1r8mE
Description: SEC7 DOMAIN OF THE ARF EXCHANGE FACTOR ARNO WITH BREFELDIN A-SENSITIZING MUTATIONS
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ARF guanyl-nucleotide exchange factor activity 3.21855719969171 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 2.34270596875878 bayes_pls_golite062009
GTPase regulator activity 2.33775275044058 bayes_pls_golite062009
enzyme regulator activity 2.18282128472415 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 2.13694141859871 bayes_pls_golite062009
small GTPase regulator activity 1.9528150458215 bayes_pls_golite062009
cytoskeletal protein binding 1.93411052758697 bayes_pls_golite062009
protein binding 1.76037270569241 bayes_pls_golite062009
binding 1.27080459409383 bayes_pls_golite062009
signal transducer activity 0.329302915338046 bayes_pls_golite062009
molecular transducer activity 0.329302915338046 bayes_pls_golite062009
phosphoinositide binding 0.0750646331148792 bayes_pls_golite062009
phospholipid binding 0.0172309833091902 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [247-393]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VSTSGKGTVN DILLHAEREG WLFKQSSNPL FSGALSWKKR WFVLSENCLY YFDQMTDKEP  60
   61 KGIITLANVG IRKVEAPSRP FMFEIFSLSD GQIKACKTEQ DGRLVEGRHS IYKICAVNDE 120
  121 DMRSWINAIS RMMAPQQHLL ARPKSTH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.522879
Match: 1fhwA
Description: Grp1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 3.17213698546013 bayes_pls_golite062009
actin binding 3.00914116198279 bayes_pls_golite062009
cytoskeletal protein binding 2.67068028643471 bayes_pls_golite062009
binding 2.65091781683225 bayes_pls_golite062009
profilin binding 1.91751880819794 bayes_pls_golite062009
actin filament binding 1.90278181549871 bayes_pls_golite062009
cell adhesion molecule binding 1.3855488465667 bayes_pls_golite062009
transporter activity 1.28986800087234 bayes_pls_golite062009
protein domain specific binding 1.24896354314328 bayes_pls_golite062009
phospholipid binding 1.09683218092034 bayes_pls_golite062009
receptor binding 1.00859318603128 bayes_pls_golite062009
phosphoinositide binding 0.71817045430443 bayes_pls_golite062009
signal transducer activity 0.704817275989342 bayes_pls_golite062009
molecular transducer activity 0.704817275989342 bayes_pls_golite062009
substrate-specific transporter activity 0.54401901869178 bayes_pls_golite062009
GTPase binding 0.18593284596663 bayes_pls_golite062009
lipid binding 0.179561240451969 bayes_pls_golite062009
protein complex binding 0.15504114076075 bayes_pls_golite062009
small GTPase binding 0.124515895045891 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle