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Protein Overview: unc-8

General Information:
Name(s) found: unc-8 / CE26381 [WormBase]
Description(s) found:
Found 24 descriptions.
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  • WBGene00006748 locus:unc-8 Degenerin unc-8 status:Partially_confirmed UniProt:Q21974 protein_id:CCD67152.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 777 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEALink to PubMed article]
    integral to membrane [IEALink to PubMed article]
    plasma membrane [ICLink to PubMed article]
    Biological Process: sodium ion transport [IEALink to PubMed article]
    ion transport [IEALink to PubMed article]
    cation transport [ISSLink to PubMed article]
    locomotion [IMPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: ion channel activity [IEALink to PubMed article]
    cation channel activity [ISSLink to PubMed article]
    sodium channel activity [IEALink to PubMed article]
    amiloride-sensitive sodium channel activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPLLTWNLI CVSSRWYTIL CLKNKVKFWL GTRLVHEPES MESRSSPYIR PSPYAGGVHP  60
   61 HFEEEDDRSK LHASALYSER RTSSRKSLRS QKIDYHTTTI KSLWFDFCAR TSSHGIPYVA 120
  121 TSSFFGRYVW AALFMCMLMA FLLQTYWTMS EYLQYRTIIE MQLQFEAAAF PAATVCNLNA 180
  181 FKYSELTQYE EIKEGFDYWE RVINARMMSD SMKPGGDILE AISVRKKRSK SRDQLLFPID 240
  241 DEDLEGAVYQ PVFVRCTCMN MEQCVPNRNP LEVNASICMC FEDVTRGLIW PCYPTSVWTV 300
  301 KKCSGCSISN TCPDPDGPNA SKQIAKHNSP LPCLCQSISH HCMVHPKDEI RWWNPNNYTV 360
  361 YSVTEPPTTE ITETEEAFGL SDLKDAGAIT TQTKENLIFL VAALPRETRR NLSYTLNEFV 420
  421 LRCSFNSKDC SMERDFKLHV DPEYGNCYTF NFNDSVELKN SRAGPMYGLR LLLNVHQSDY 480
  481 MPTTEAAGVR LVVHEQDQEP FPDTFGYSAP TGFISSFGLK TKELHRLSAP WGNCSDTFRP 540
  541 VPYIYNEHYS PEGCHRNCFQ LKVLEICGCG DPRFPLPSEE HRHCNAKSKI DRQCLSNLTS 600
  601 DSGGYHHLHE QCECRQPCHE KVFETAYSAS AWPSQNFKIG TDCPAVSDIF NDTEACTEYY 660
  661 RQNTAYIEIY YEQLNFESLK ETAGYTLVNL FSDFGGNIGL WIGFSVITFA EFAELFCEIC 720
  721 KLMYFKGIVY VQKKMQGKEY TSSSLMHIDF LQRSPKKSQP GEDEVSTNES TKELMSK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..89] deduced N/A No confident structure predictions are available.
    2 View Details [90..290] FFAS03 4.03 No description for 2qtsA was found.
    3 View Details [291..777] PSI-BLAST 87.0 No description for 2qtsA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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