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Protein Overview: lin-17

General Information:
Name(s) found: lin-17 / CE25569 [WormBase]
Description(s) found:
Found 20 descriptions.
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  • WBGene00003006 locus:lin-17 status:Confirmed UniProt:G5EDV1 protein_id:CCD70412.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 558 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEALink to PubMed article]
    plasma membrane [IDALink to PubMed article]
    Biological Process: polarity specification of proximal/distal axis [IGILink to PubMed articleLink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    regulation of cell fate specification [IMPLink to PubMed articleLink to PubMed article]
    hermaphrodite genitalia development [IGILink to PubMed article][IMPLink to PubMed article]
    regulation of asymmetric cell division [IGILink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    tail tip morphogenesis [IMPLink to PubMed article]
    cell surface receptor linked signaling pathway [IEALink to PubMed article]
    regulation of vulval development [IGILink to PubMed article][IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    polarity specification of anterior/posterior axis [IGILink to PubMed article][IMPLink to PubMed article]
    establishment of anatomical structure orientation [IGILink to PubMed article][IMPLink to PubMed article]
    gonad development [IMPLink to PubMed article]
    asymmetric protein localization involved in cell fate determination [IGILink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    morphogenesis of an epithelium [IGILink to PubMed article][IMPLink to PubMed article]
    regulation of cell migration [IMPLink to PubMed article]
    Molecular Function: G-protein coupled receptor activity [IEALink to PubMed article]
    non-G-protein coupled 7TM receptor activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMHSLGIILL FIPLATGSIF DQAVKGKCIP IDIELCKDLP YNYTYFPNTI LHNDQHTLQT  60
   61 HTEHFKPLMK TKCHPHIHFF ICSVFAPMCP IGMPQAVTSC KSVCEQVKAD CFSILEEFGI 120
  121 GWPEPLNCAQ FPDPPELCMK PTEDEITGGF SAPRLPTKGS SSSSSKPTGC PSDLVDVDPH 180
  181 DPKSHCAFAC QSNVMFSTDN KRMVRSWSIW FAAANAGVAL FSFLTFAIDR KRFRFPERCV 240
  241 FYLSLCIFIS SLPYLTPLFI DAPIRSCHAL GNGRSYLSIG TFDNSYCLAS FLLNYFFSTA 300
  301 AALWWLMFSF TLYLSGGRKW VPEGIEACSS YVHFVAWGLS SLATIIVLIF NKVDASELTA 360
  361 LCSVGNLNSI ALLWFVIVPR TICIVIGTCF IVGGFASMCR ERISFRTRGT DTSKLEKLMV 420
  421 KMGFFCALFI LPNVIELVCQ CYKFMILTQW TRMTIDCKQQ SGACHRPTPP QAEIYMTAVI 480
  481 SSLATGFSCL MWVLSAKTVH AWKNFIFCGM CSSAPVKNPI EPSTRPLLEP PTAPPPQPPV 540
  541 YMQMATNPQN SWRPSKVV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..181] PSI-BLAST 34.69897 Frizzled 8 (FZ8)
    2 View Details [182..558] PSI-BLAST 17.09691 Rhodopsin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • Wnt receptor activity
    		•  5.34849208575619 bayes_pls_golite062009
  • Wnt-protein binding
    		•  4.48351937520811 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  4.38708793497137 bayes_pls_golite062009
  • receptor activity
    		•  4.1046853496316 bayes_pls_golite062009
  • signal transducer activity
    		•  3.17034085692897 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.17034085692897 bayes_pls_golite062009
  • binding
    		•  1.75284371400205 bayes_pls_golite062009
  • protein binding
    		•  1.1012033332744 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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