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Protein Overview: hpl-2

General Information:
Name(s) found: hpl-2 / CE25037 [WormBase]
Description(s) found:
Found 21 descriptions.
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  • WBGene00001996 locus:hpl-2 status:Confirmed UniProt:G5EFS9 protein_id:CAB07243.2 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 301 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][IEALink to PubMed article]
    endoplasmic reticulum [IEALink to PubMed article]
    chromatin [IEALink to PubMed article]
    Biological Process: negative regulation of vulval development [IGILink to PubMed article][IMPLink to PubMed article]
    germ cell development [IGILink to PubMed article][IMPLink to PubMed article]
    gonad development [IGILink to PubMed article][IMPLink to PubMed article]
    negative regulation of Ras protein signal transduction [IGILink to PubMed article]
    regulation of cell differentiation [IGILink to PubMed article]
    nematode larval development [IGILink to PubMed article]
    positive regulation of growth rate [IGILink to PubMed article][IMPLink to PubMed article]
    chromatin assembly or disassembly [IEALink to PubMed article]
    reproduction [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: chromatin binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSKSTKRAK IEDPKDNVFM VEKVLDKRTG KAGRDEFLIQ WQGFPESDSS WEPRENLQCV  60
   61 EMLDEFEREF SKREKPIRKR HSQKPEPSED QADPEEDKDE KKETNQNDKF SLEGKQLKCI 120
  121 VGLTKGPGEL HFLCKFSDDT ARLLPAKEVN SRYRPFVDAY GEFLKKKMER RHKRISEGKK 180
  181 KRSIEEDDAD DEWPEMPPGH RILTTEEHEL QRRKESKISQ DVEMTEAQTA ADMLNDMHMA 240
  241 ANGDLLSSFP QDFLEDSGDG EVHEAAILSV FDDNSNSPPP CPIVVDTVPD DDDSLLFPRN 300
  301 S

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..185] PSI-BLAST 22.522879 Tandem chromodomains of human CHD1 complexed with Histone H3 Tail containing trimethyllysine 4 and dimethylarginine 2
    2 View Details [186..301] MSA 12.165997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription repressor activity
    		•  4.08500855631983 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.64390820819794 bayes_pls_golite062009
  • methylated histone residue binding
    		•  3.42338304360938 bayes_pls_golite062009
  • chromatin binding
    		•  3.1924157640698 bayes_pls_golite062009
  • binding
    		•  3.06758476214113 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.19167058827256 bayes_pls_golite062009
  • DNA binding
    		•  2.05514577638135 bayes_pls_golite062009
  • histone binding
    		•  2.00388175060339 bayes_pls_golite062009
  • protein binding
    		•  1.61683263008775 bayes_pls_golite062009
  • general transcriptional repressor activity
    		•  0.75184432495983 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.294457188332415 bayes_pls_golite062009
  • catalytic activity
    		•  0.14067200158938 bayes_pls_golite062009
  • transcription activator activity
    		•  0.136090220479238 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle