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View Structure Prediction Details

Protein: hpl-2
Organism: Caenorhabditis elegans
Length: 301 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for hpl-2.

Description E-value Query
Range
Subject
Range
hpl-2 - 'chromo' (CHRromatin Organization MOdifier) domain status:Confirmed UniProt:Q9U3C6 protein_id:CAB542...
223.0 [0..1] [301..1]

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Predicted Domain #1
Region A:
Residues: [1-185]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSKSTKRAK IEDPKDNVFM VEKVLDKRTG KAGRDEFLIQ WQGFPESDSS WEPRENLQCV  60
   61 EMLDEFEREF SKREKPIRKR HSQKPEPSED QADPEEDKDE KKETNQNDKF SLEGKQLKCI 120
  121 VGLTKGPGEL HFLCKFSDDT ARLLPAKEVN SRYRPFVDAY GEFLKKKMER RHKRISEGKK 180
  181 KRSIE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.522879
Match: 2b2uA
Description: Tandem chromodomains of human CHD1 complexed with Histone H3 Tail containing trimethyllysine 4 and dimethylarginine 2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription repressor activity 4.08500855631983 bayes_pls_golite062009
transcription regulator activity 3.64390820819794 bayes_pls_golite062009
methylated histone residue binding 3.42338304360938 bayes_pls_golite062009
chromatin binding 3.1924157640698 bayes_pls_golite062009
binding 3.06758476214113 bayes_pls_golite062009
nucleic acid binding 2.19167058827256 bayes_pls_golite062009
DNA binding 2.05514577638135 bayes_pls_golite062009
histone binding 2.00388175060339 bayes_pls_golite062009
protein binding 1.61683263008775 bayes_pls_golite062009
general transcriptional repressor activity 0.75184432495983 bayes_pls_golite062009
transcription corepressor activity 0.294457188332415 bayes_pls_golite062009
catalytic activity 0.14067200158938 bayes_pls_golite062009
transcription activator activity 0.136090220479238 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [186-301]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDDADDEWPE MPPGHRILTT EEHELQRRKE SKISQDVEMT EAQTAADMLN DMHMAANGDL  60
   61 LSSFPQDFLE DSGDGEVHEA AILSVFDDNS NSPPPCPIVV DTVPDDDDSL LFPRNS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle