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Protein Overview: air-2

General Information:
Name(s) found: air-2 / CE24761 [WormBase]
Description(s) found:
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  • WBGene00000099 locus:air-2 Aurora\/IPL1-related protein kinase 2 status:Confirmed UniProt:O01427 protein_id:CCD61317.1 [WormBase]
  • gi|74955890|sp|O01427.2|AIR2_CAEEL RecName: Full=Aurora/Ipl1-related protein kinase 2; AltName: Full=Aurora-B [NCBI NR]
  • gi|6671491|gb|AAB52459.2| Aurora/ipl1 related kinase protein 2 [Caenorhabditis elegans] [NCBI NR]
  • gi|3249053|gb|AAC70945.1| aurora/Ipl1-related protein kinase 2 [Caenorhabditis elegans] [NCBI NR]
  • gi|17505246|ref|NP_491714.1| Aurora/Ipl1 Related kinase family member (air-2) [Caenorhabditis elegans] [NCBI NR]
  • pir||T43221 serine/threonine-specific protein kinase (EC 2.7.1.-) 2 - Caenorhabditis elegans [NCBI NR]
  • Aurora/IPL1-related protein kinase 2 OS=Caenorhabditis elegans GN=air-2 PE=1 SV=2 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE24761 WBGene00000099 locus:air-2 protein kinase status:Confirmed TR:O01427 protein_id:AAB52459.2 [wormpep150.fasta]
  • 24761 WBGene00000099 locus:air-2 protein kinase status:Confirmed TR:O01427 protein_id:AAB52459.2 [wormpep130-phg-ecoli-orf-rand.fasta]
  • Aurora/Ipl1 Related kinase, CYtoKinesis defect CYK-6, LEThal LET-603, STerile and Uncoordinated STU-7 (34.7 kD) (air-2) [Caenorhabditis elegans]gi|6671491|gb|AAB52459.2| Aurora/ipl1 related kinase protein 2 [Caenorhabditis elegans]gi|3249053|gb|AAC70945 [nrdb_11152004_Chlamydomonas]
  • locus:air-2 protein kinase status:Confirmed TR:O01427 protein_id:AAB52459.2 [wormpep115.fasta.reversed]
  • CE24761 locus:air-2 protein kinase status:Confirmed [wormpep80.hongbin]
  • CE24761 WBGene00000099 locus:air-2 protein kinase status:Confirmed UniProt:O01427 protein_id:AAB52459.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE24761 WBGene00000099 locus:air-2 protein kinase status:Confirmed UniProt:O01427 protein_id:AAB52459.2| [wormORF-contam.fasta]
  • Aurora/Ipl1 Related kinase family member (air-2) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Aurora/ipl1 related kinase protein 2 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • aurora/Ipl1-related protein kinase 2 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE24761 WBGene00000099 locus:air-2 protein kinase status:Confirmed SW:O01427 protein_id:AAB52459.2 [WormBase_C-elegans_wp180_08-19-2007_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE24761 WBGene00000099 locus:air-2 protein kinase status:Confirmed UniProt:O01427 protein_id:CCD61317.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE24761 WBGene00000099 locus:air-2 status:Confirmed UniProt:O01427 protein_id:CCD61317.1 Aurora\/IPL1-related protein kinase 2 [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 305 amino acids

    Gene Ontology:
    Cellular Component: condensed chromosome [IDALink to PubMed article]
    spindle [IDALink to PubMed article]
    condensed nuclear chromosome [IDALink to PubMed article]
    Biological Process: cytokinesis, completion of separation [IMPLink to PubMed article]
    hermaphrodite genitalia development [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    chromosome condensation [IMPLink to PubMed article]
    chromosome segregation [IMPLink to PubMed article]
    protein amino acid phosphorylation [IEALink to PubMed article]
    meiosis [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: ATP binding [IEALink to PubMed article]
    protein tyrosine kinase activity [IEALink to PubMed article]
    protein kinase activity [IEALink to PubMed article]
    protein serine/threonine kinase activity [IEALink to PubMed article][NASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MENKPPVINL PEKETVNTPQ KGGKFTINDF EIGRPLGKGK FGSVYLARTK TGHFHVAIKV  60
   61 LFKSQLISGG VEHQLEREIE IQSHLNHPNI IKLYTYFWDA KKIYLVLEYA PGGEMYKQLT 120
  121 VSKRFSEPTA AKYMYEIADA LSYCHRKNVI HRDIKPENLL IGSQGELKIG DFGWSVHAPS 180
  181 NKRQTMCGTM DYLPPEMVNG ADHSDAVDLW AIGVLCYEFL VGKPPFEHED QSKTYAAIKA 240
  241 ARFTYPDSVK KGARDLIGRL LVVDPKARCT LEQVKEHYWI QGMMEAKIRA EKQQKIEKEA 300
  301 SLRNH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..305] PSI-BLAST 66.522879 No description for 2j4zA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein kinase activity
    		•  5.17195961442593 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.04467222534257 bayes_pls_golite062009
  • kinase activity
    		•  4.85903980916957 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.46123870227889 bayes_pls_golite062009
  • transferase activity
    		•  3.26787750561728 bayes_pls_golite062009
  • binding
    		•  2.31930216202447 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • protein binding
    		•  1.22565748038754 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.1208666000428 bayes_pls_golite062009
  • tubulin binding
    		•  0.488928950975855 bayes_pls_golite062009
  • actin binding
    		•  0.464111806616899 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.282849280638519 bayes_pls_golite062009
  • signal transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • microtubule binding
    		•  0.196718452862042 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.0556163711947139 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.00652065412910241 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle