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Protein Overview: aap-1

General Information:
Name(s) found: aap-1 / CE23248 [WormBase]
Description(s) found:
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  • WBGene00000001 locus:aap-1 status:Confirmed UniProt:G5EDP9 protein_id:CCD66201.1 [WormBase]
  • gi|6760403|gb|AAF28335.1|AF209707_1 phosphoinositide 3-kinase adapter subunit [Caenorhabditis elegans] [NCBI NR]
  • gi|17510927|ref|NP_491522.1| phosphoinositide kinase AdAPter subunit family member (aap-1) [Caenorhabditis elegans] [NCBI NR]
  • gi|14578239|gb|AAF60427.2| Phosphoinositide kinase adapter subunit protein 1 [Caenorhabditis elegans] [NCBI NR]
  • [wormpep67.fasta]
  • CE23248 WBGene00000001 locus:aap-1 status:Confirmed TR:Q9N597 protein_id:AAF60427.2 [wormpep150.fasta]
  • 23248 WBGene00000001 locus:aap-1 status:Confirmed TR:Q9N597 protein_id:AAF60427.2 [wormpep130-phg-ecoli-orf-rand.fasta]
  • phosphoinositide 3-kinase AGE-1 AdAPter subunit (58.5 kD) (aap-1) [Caenorhabditis elegans]gi|14578239|gb|AAF60427.2| Phosphoinositide kinase adapter subunit protein 1 [Caenorhabditis elegans]gi|6760403|gb|AAF28335.1| phosphoinositide 3-kinase adapter su [nrdb_11152004_Chlamydomonas]
  • locus:aap-1 status:Confirmed TR:Q9N597 protein_id:AAF60427.2 [wormpep115.fasta.reversed]
  • CE23248 locus:aap-1 status:Confirmed [wormpep80.hongbin]
  • CE23248 WBGene00000001 locus:aap-1 status:Confirmed UniProt:Q9N597_CAEEL protein_id:AAF60427.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE23248 WBGene00000001 locus:aap-1 status:Confirmed UniProt:Q9N597_CAEEL protein_id:AAF60427.2| [wormORF-contam.fasta]
  • phosphoinositide 3-kinase adapter subunit [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Phosphoinositide kinase adapter subunit protein 1 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • phosphoinositide kinase AdAPter subunit family member (aap-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE23248 WBGene00000001 locus:aap-1 status:Confirmed UniProt:Q9N597 protein_id:AAF60427.2 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE23248 WBGene00000001 locus:aap-1 status:Confirmed UniProt:G5EDP9 protein_id:CCD66201.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • Phosphoinositide 3-kinase adapter subunit OS=Caenorhabditis elegans GN=aap-1 PE=1 SV=1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 522 amino acids

    Gene Ontology:
    Cellular Component: cell [IDALink to PubMed article]
    Biological Process: dauer larval development [IMPLink to PubMed article]
    insulin receptor signaling pathway [IMPLink to PubMed article]
    determination of adult lifespan [IMPLink to PubMed article]
    Molecular Function: protein kinase binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTTPGTPHG VTHSLMEQGW YWADADRSAV SKALSDQPDG SFIVRNASTP GDYTLSVKFA  60
   61 AQVKLLRIVV KDGKCGFNTD SLTHDSVVRL IEFHRNISLN IFNDALDVRL LYPVSVRRNS 120
  121 QNGKPFFKKG QLQQRMILSA KNDHDWRERL EMENLRAVHL AFERGAKLYD SAHQEMERAE 180
  181 SLYHALNQSV RDNEIKLGKL NNLLEAETDV VTQIQGSQTT SEMLKGAFAN NKTFVEESIR 240
  241 RINTELTSSK DKKKTLSGIL DEIAMKRSNS KTRLCKLMEL RSAVYDKMEP ALCSRMAAML 300
  301 DAGAEMINSE PTKVTQLLVD MELKWTPAQY LMCGTSKENA ANALIHARYR IAQLDKAVGL 360
  361 KREPQDGIFL IRGSSSHGDK LVLSVLHGER VSHCLIEQNE EGWGFEHSNV YLTTISDFVR 420
  421 YYSHFSLETH ADAIKTPLRT PAFDAVTSDT SKPLRNGPGQ VFTALPISRK YMEKALLTDD 480
  481 PTKPPESPEP RPDSWDSPSP DTPSSSDSRL VHPTTLPKSI PE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..442] PSI-BLAST 45.69897 Tyrosine phosphatase; Tyrosine phoshatase shp-2
    2 View Details [443..522] PSI-BLAST 25.221849 No description for 2ozoA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.78762232945822 bayes_pls_golite062009
  • protein tyrosine phosphatase activity
    		•  1.56682857973533 bayes_pls_golite062009
  • protein binding
    		•  1.4273874265634 bayes_pls_golite062009
  • signal transducer activity
    		•  1.37370552536239 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.37370552536239 bayes_pls_golite062009
  • insulin receptor binding
    		•  1.03645420161146 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  0.99961589504873 bayes_pls_golite062009
  • phosphoprotein phosphatase activity
    		•  0.971261991185124 bayes_pls_golite062009
  • phosphatase activity
    		•  0.61426463918033 bayes_pls_golite062009
  • molecular adaptor activity
    		•  0.58947294551094 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  0.52889761132084 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.38804729252204 bayes_pls_golite062009
  • receptor binding
    		•  0.24683439420295 bayes_pls_golite062009
  • receptor activity
    		•  0.22418018792939 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.0904972759345899 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle