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Protein Overview: daf-5

General Information:
Name(s) found: daf-5 / CE18985 [WormBase]
Description(s) found:
Found 20 descriptions.
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  • WBGene00000901 locus:daf-5 status:Confirmed UniProt:G5EDM7 protein_id:CAB03453.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 627 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [IGILink to PubMed article]
    Molecular Function: protein binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDSPIGSSQ QVEPEHRTPD LMDIDPLIAN LKALHEETRS DDDDDGQPST SAKRKDSRAD  60
   61 GIVIHQKKYS DPGRFLWIWL LGVRVPALSI DGEPHLPIEI LDDMLTKKDK KDQMSFQNLL 120
  121 RYKNVYIRMA SPSQFRAVME KSKECENLNI TSLSLMSRSD IERIMGELRL ESMLTLAEHD 180
  181 NWDISDRVHV VHVNFIDYCS EWLESDDLEE DVMQSGTHGY WYKNRRNMRC IECQHCEGKF 240
  241 TPTDFIMHHH YPIKPSGFVH TGCNSFQWIR LIEVFDKSNE NLEAWNKFVL NSHRAGKREY 300
  301 DEAAPHQAPP KRPAMETPVP VAADNGWEAD EEEEGEEIVD RDADIEKCKL RNKKKMENLH 360
  361 IADFLGPSGS KGLKPRNKFE AVIIEQLNKM DDAALEALFL KSPEEYNLWV KESDFTHKVV 420
  421 TQQQEWKAKM KDPNFKSRAS ANFDVSKGEF DNMRHFDNAS KATRQEIQQL AEQFANLDRD 480
  481 AKLLTPMEFV LREHALLKNV SADAIRVLCN RPPLPPLPPP PPPPKPKPAP VQPISLGNIN 540
  541 FVALAQQLIA SGIKLPLPIV TPPVVSTPAP VITPIPAALP ISPNSDFLKQ QLSTAMSSPA 600
  601 LLSLYPKLTA GAYEQLAQFI KTTTVKN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..222] FFAS03 1.0 Retinal determination protein Dachshund
    2 View Details [223..312] FFAS03 1.93 SMAD4-binding domain of oncoprotein Ski
    3 View Details [313..374] deduced N/A No confident structure predictions are available.
    4 View Details [375..627] MSA 32.213997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  3.15084451351262 bayes_pls_golite062009
  • DNA binding
    		•  1.89121395172205 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.85709490142946 bayes_pls_golite062009
  • transcription factor activity
    		•  1.63947569382682 bayes_pls_golite062009
  • binding
    		•  1.25832675558318 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.602655539932971 bayes_pls_golite062009
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  1.83423962165591 bayes_pls_golite062009
  • binding
    		•  1.34661437993129 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.859383583344931 bayes_pls_golite062009
  • DNA binding
    		•  0.736673094382699 bayes_pls_golite062009
  • protein binding
    		•  0.531073393510436 bayes_pls_golite062009
  • transcription factor activity
    		•  0.40038585689413 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.183703906743894 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle