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Protein Overview: lin-3

General Information:
Name(s) found: lin-3 / CE18670 [WormBase]
Description(s) found:
Found 20 descriptions.
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  • WBGene00002992 locus:lin-3 Protein lin-3 status:Confirmed UniProt:Q03345 protein_id:CAD27623.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 436 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [ISSLink to PubMed article]
    extracellular space [ISSLink to PubMed article]
    Biological Process: ovulation from ovarian follicle [IMPLink to PubMed article]
    positive regulation of vulval development [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    regulation of cell fate specification [IMPLink to PubMed article]
    inductive cell-cell signaling [IEPLink to PubMed article][IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    male genitalia development [IMPLink to PubMed article]
    epidermal growth factor receptor signaling pathway [IGILink to PubMed article][ISSLink to PubMed article]
    post-embryonic development [IMPLink to PubMed article]
    oviposition [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    gamete generation [IMPLink to PubMed article]
    reproduction [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    Molecular Function: epidermal growth factor receptor activating ligand activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRKMLLFCIL LLFMPQFTES CLPSWFRQER SAPEQLQSAE NAAENSGSVP PDTSRNSLET  60
   61 NEIGDAPSST STPETPTETT ISEAGDDEKR TEEVAKELIE KEAEYEGEYE DEKVDEEVEE 120
  121 ALKYNEDATQ DATSTLKPAV RKEIEKLKEA KCKDYCHHNA TCHVEVIFRE DRVSAVVPSC 180
  181 HCPQGWEGTR CDRHYVQAFY APINGRYNVR LSTMSSTAQL LVQQSSTSAI PAFAFLIVML 240
  241 IMFITIVVYA YRRMSKRSDD MTYTMSHMCP PEAFNVLKTP NGRHIPVHQI PSCSYTIPTP 300
  301 GTVPPNISST PGSRIPTRQQ AIRNNEQARN NFFSILRSQG TIPSRSINDD DTPKHYKSVP 360
  361 RVEVSAINYS GHIDFSTVSY QSTESEVSKA SVTCPPPAHT VINIELDSAD TNFRSPSRSS 420
  421 GEQGSPATCE PMIRHT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..185] FFAS03 0.996 COAGULATION FACTOR, NMR, 20 STRUCTURES
    2 View Details [186..436] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • epidermal growth factor receptor binding
    		•  4.08248920636506 bayes_pls_golite062009
  • receptor binding
    		•  2.76510818289785 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  1.90147602324004 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  1.85625693531369 bayes_pls_golite062009
  • signal transducer activity
    		•  1.66370136016696 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.66370136016696 bayes_pls_golite062009
  • binding
    		•  1.62855234773036 bayes_pls_golite062009
  • growth factor activity
    		•  1.47902993477961 bayes_pls_golite062009
  • transcription factor binding
    		•  0.568897560911761 bayes_pls_golite062009
  • protein binding
    		•  0.448653666571103 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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