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Protein Overview: unc-17

General Information:
Name(s) found: unc-17 / CE17307 [WormBase]
Description(s) found:
Found 28 descriptions.
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  • WBGene00006756 locus:unc-17 Vesicular acetylcholine transporter unc-17 status:Confirmed UniProt:P34711 protein_id:CCD68241.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 532 amino acids

    Gene Ontology:
    Cellular Component: synaptic vesicle [IDALink to PubMed article]
    integral to membrane [IEALink to PubMed article]
    integral to synaptic vesicle membrane [NASLink to PubMed article]
    synapse [IDALink to PubMed articleLink to PubMed article]
    neuron projection [IDALink to PubMed article]
    Biological Process: regulation of neurotransmitter secretion [IMPLink to PubMed article]
    regulation of pharyngeal pumping [IGILink to PubMed article][IMPLink to PubMed article]
    drug transport [IEALink to PubMed article]
    acetylcholine transport [ISSLink to PubMed article]
    regulation of locomotion [IMPLink to PubMed article]
    phosphate transport [IEALink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    transport [IEALink to PubMed article]
    Molecular Function: phosphate transmembrane transporter activity [IEALink to PubMed article]
    acetylcholine transmembrane transporter activity [ISSLink to PubMed article]
    drug transmembrane transporter activity [IEALink to PubMed article]
    transporter activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGFNVPVINR DSEILKADAK KWLEQQDNQK KCVLVIVSIA LLLDNMLYMV IVPIIPKYLR  60
   61 DIHNYQVTFE GYHNETSQLA NGTYLVREVG GRINFLDEEL ELGWLFASKA LLQIFVNPFS 120
  121 GYIIDRVGYE IPMILGLCTM FFSTAIFALG KSYGVLLFAR SLQGFGSAFA DTSGLAMIAD 180
  181 RFTEENERSA ALGIALAFIS FGCLVAPPFG SVLYSLAGKP VPFLILSFVC LADAIAVFMV 240
  241 INPHRRGTDS HGEKVQGTPM WRLFMDPFIA CCSGALIMAN VSLAFLEPTI TTWMSEMMPD 300
  301 TPGWLVGVIW LPPFFPHVLG VYVTVKMLRA FPHHTWAIAM VGLAMEGIAC FAIPYTTSVM 360
  361 QLVIPLSFVC FGIALIDTSL LPMLGHLVDT RHVSVYGSVY AIADISYSLA YAFGPIIAGW 420
  421 IVTNWGFTAL NIIIFATNVT YAPVLFLLRK VHSYDTLGAK GDTAEMTQLN SSAPAGGYNG 480
  481 KPEATTAESY QGWEDQQSYQ NQAQIPNHAV SFQDSRPQAE FPAGYDPLNP QW

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..532] PSI-BLAST 38.69897 Crystal Structure of the Glycerol-3-Phosphate Transporter from E.Coli

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transporter activity
    		•  4.09176719149278 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.59744164024479 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.5865018981083 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  3.54194478414824 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.21266150105753 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.79369588808394 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.59419818573076 bayes_pls_golite062009
  • organic acid transmembrane transporter activity
    		•  1.24937104052238 bayes_pls_golite062009
  • secondary active transmembrane transporter activity
    		•  1.22264637452409 bayes_pls_golite062009
  • binding
    		•  1.05701989682533 bayes_pls_golite062009
  • alcohol transmembrane transporter activity
    		•  0.924836669821548 bayes_pls_golite062009
  • polyol transmembrane transporter activity
    		•  0.924836669821548 bayes_pls_golite062009
  • glycerol transmembrane transporter activity
    		•  0.812001619402678 bayes_pls_golite062009
  • symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • solute:cation symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • cation:sugar symporter activity
    		•  0.143419068761182 bayes_pls_golite062009
  • sugar:hydrogen symporter activity
    		•  0.143419068761182 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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    Created and Maintained by: Michael Riffle