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Protein Overview: ahcy-1

General Information:
Name(s) found: ahcy-1 / CE17154 [WormBase]
Description(s) found:
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  • WBGene00019322 locus:ahcy-1 Adenosylhomocysteinase status:Confirmed UniProt:P27604 protein_id:CCD68626.1 [WormBase]
  • pir||T32918 adenosylhomocysteinase (EC 3.3.1.1) - Caenorhabditis elegans [NCBI NR]
  • gi|298816|gb|AAB25906.1| S-adenosylhomocysteine hydrolase; AHH [Caenorhabditis elegans] [NCBI NR]
  • gi|2804454|gb|AAB97565.1| Hypothetical protein K02F2.2 [Caenorhabditis elegans] [NCBI NR]
  • gi|17506425|ref|NP_491955.1| hypothetical protein K02F2.2 [Caenorhabditis elegans] [NCBI NR]
  • gi|156326|gb|AAA28062.1| S-adenosylhomocysteine hydrolase [NCBI NR]
  • gi|134182|sp|P27604.1|SAHH_CAEEL RecName: Full=Adenosylhomocysteinase; Short=AdoHcyase; AltName: Full=S-adenosyl-L-homocysteine hydrolase; AltName: Full=Protein dumpy-14 [NCBI NR]
  • Adenosylhomocysteinase OS=Caenorhabditis elegans GN=ahcy-1 PE=3 SV=1 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE17154 WBGene00019322 S-adenosylhomocysteine hydrolase status:Confirmed SW:P27604 protein_id:AAB97565.1 [wormpep150.fasta]
  • 17154 WBGene00019322 S-adenosylhomocysteine hydrolase status:Confirmed SW:P27604 protein_id:AAB97565.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • s-adenosylhomocysteine hydrolase, DumPY : shorter than wild-type DPY-14 (47.5 kD) (dpy-14) [Caenorhabditis elegans]gi|2804454|gb|AAB97565.1| Hypothetical protein K02F2.2 [Caenorhabditis elegans]gi|298816|gb|AAB25906.1| S-adenosylhomocysteine hydrolase; [nrdb_11152004_Chlamydomonas]
  • locus:dpy-14 S-adenosylhomocysteine hydrolase status:Confirmed SW:P27604 protein_id:AAB97565.1 [wormpep115.fasta.reversed]
  • CE17154 locus:dpy-14 S-adenosylhomocysteine hydrolase status:Confirmed [wormpep80.hongbin]
  • CE17154 WBGene00019322 S-adenosylhomocysteine hydrolase status:Confirmed UniProt:SAHH_CAEEL protein_id:AAB97565.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE17154 WBGene00019322 S-adenosylhomocysteine hydrolase status:Confirmed UniProt:SAHH_CAEEL protein_id:AAB97565.1| [wormORF-contam.fasta]
  • Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase) (AdoHcyase) (Protein dumpy-14) [nr-271106-contam.fasta]
  • S-adenosylhomocysteine hydrolase; AHH [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • S-adenosylhomocysteine hydrolase [nr-271106-contam.fasta]
  • K02F2.2 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Hypothetical protein K02F2.2 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE17154 WBGene00019322 locus:ahcy-1 S-adenosylhomocysteine hydrolase status:Confirmed UniProt:P27604 protein_id:AAB97565.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE17154 WBGene00019322 locus:ahcy-1 S-adenosylhomocysteine hydrolase status:Confirmed UniProt:P27604 protein_id:CCD68626.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE17154 WBGene00019322 locus:ahcy-1 status:Confirmed UniProt:P27604 protein_id:CCD68626.1 Adenosylhomocysteinase [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 437 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: negative regulation of multicellular organism growth [IMPLink to PubMed article]
    locomotory behavior [IMPLink to PubMed articleLink to PubMed article]
    nematode larval development [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed article]
    post-embryonic body morphogenesis [IMPLink to PubMed article]
    one-carbon metabolic process [IEALink to PubMed article]
    growth [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    Molecular Function: adenosylhomocysteinase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQSKPAYKV ADIKLADFGR KEIILAENEM PGLMAMRSKY GPSQPLKGAR IAGCLHMTIQ  60
   61 TAVLIETLTA LGAEVQWSSC NIFSTQDHAA AAIAQTGVPV YAWKGETDEE YEWCIEQTIV 120
  121 FKDGQPLNMI LDDGGDLTNL VHAKYPQYLA GIRGLSEETT TGVHNLAKML AKGDLKVPAI 180
  181 NVNDSVTKSK FDNLYGIRES LPDGIKRATD VMLAGKVAVV AGYGDVGKGS AASLKAFGSR 240
  241 VIVTEIDPIN ALQAAMEGYE VTTLEEAAPK ANIIVTTTGC KDIVTGKHFE LLPNDAIVCN 300
  301 VGHFDCEIDV KWLNTNATKK DTIKPQVDRY TLKNGRHVIL LAEGRLVNLG CATGHPSFVM 360
  361 SNSFTNQVLA QVELWTKFGT PQEYKLGLYV LPKTLDEEVA YLHLAQLGVK LTKLSDEQAS 420
  421 YLGVPVAGPY KPDHYRY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-1 hcp1 IP from december2004 Cheeseman, I.M., et al. (2005)
    View Run hcp-2 hcp2 ip from december Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..437] PSI-BLAST 136.0 S-adenosylhomocystein hydrolase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • adenosylhomocysteinase activity
    		•  4.75102111339352 bayes_pls_golite062009
  • trialkylsulfonium hydrolase activity
    		•  4.75102111339352 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.9367410227151 bayes_pls_golite062009
  • binding
    		•  0.784517759335365 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  0.418775403210681 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  0.32207755075663 bayes_pls_golite062009
  • DNA binding
    		•  0.158019531459925 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.0191997392158629 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.012678711735872 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle