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Protein Overview: trt-1

General Information:
Name(s) found: trt-1 / CE15748 [WormBase]
Description(s) found:
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  • WBGene00006618 locus:trt-1 status:Confirmed UniProt:O45321 protein_id:CAB09413.1 [WormBase]
  • pir||T20392 hypothetical protein DY3.4 - Caenorhabditis elegans [NCBI NR]
  • gi|3875349|emb|CAB09413.1| C. elegans protein DY3.4a, partially confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|17506433|ref|NP_492373.1| Telomerase Reverse Transcriptase family member (trt-1) [Caenorhabditis elegans] [NCBI NR]
  • [wormpep67.fasta]
  • CE15748 WBGene00006618 locus:trt-1 Reverse transcriptase (RNA-dependent DNA polymerase) status:Partially_confirmed TR:O45321 protein_id:CAB09413.1 [wormpep150.fasta]
  • 15748 WBGene00006618 locus:trt-1 Reverse transcriptase (RNA-dependent DNA polymerase) status:Partially_confirmed TR:O45321 protein_id:CAB09413.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • telomerase Reverse Transcriptase (65.8 kD) (trt-1) [Caenorhabditis elegans]gi|3875349|emb|CAB09413.1| Hypothetical protein DY3.4a [Caenorhabditis elegans]gi|7498274|pir||T20392 hypothetical protein DY3.4 - Caenorhabditis elegans [nrdb_11152004_Chlamydomonas]
  • locus:trt-1 Reverse transcriptase (RNA-dependent DNA polymerase) status:Partially_confirmed TR:O45321 protein_id:CAB09413.1 [wormpep115.fasta.reversed]
  • CE15748 locus:trt-1 Reverse transcriptase (RNA-dependent DNA polymerase) status:Partially_confirmed TR:O45321 protein_id:CAB09413.1 [wormpep80.hongbin]
  • CE15748 WBGene00006618 locus:trt-1 Reverse transcriptase (RNA-dependent DNA polymerase) status:Partially_confirmed UniProt:O45321_CAEEL protein_id:CAB09413.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE15748 WBGene00006618 locus:trt-1 Reverse transcriptase (RNA-dependent DNA polymerase) status:Partially_confirmed UniProt:O45321_CAEEL protein_id:CAB09413.1| [wormORF-contam.fasta]
  • Hypothetical protein DY3.4a [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Telomerase Reverse Transcriptase family member (trt-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE15748 WBGene00006618 locus:trt-1 Reverse transcriptase (RNA-dependent DNA polymerase) status:Partially_confirmed UniProt:O45321 protein_id:CAB09413.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE15748 WBGene00006618 locus:trt-1 Reverse transcriptase (RNA-dependent DNA polymerase) status:Confirmed UniProt:O45321 protein_id:CAB09413.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE15748 WBGene00006618 locus:trt-1 status:Confirmed UniProt:O45321 protein_id:CAB09413.1 [wormpep246-ecoli-contam.fasta]
  • Telomerase Reverse Transcriptase OS=Caenorhabditis elegans GN=trt-1 PE=4 SV=1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 561 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    Biological Process: RNA-dependent DNA replication [IEALink to PubMed article]
    telomere maintenance via telomerase [IMP]
    Molecular Function: DNA binding [IEALink to PubMed article]
    telomeric template RNA reverse transcriptase activity [IEALink to PubMed article]
    RNA-directed DNA polymerase activity [IEALink to PubMed article]
    RNA binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAPTIKSSLT TLHEEIRKYD KRRHWNTIIR KSAHLSLVRN IFKKKRRQKL NYRHMSTFLA  60
   61 SSENISNIRD TVVLLEINKL SQSILSSRNI FELRKLKPTR KMVEIEHCFV SKNDTFVACS 120
  121 KLISMFHLEK YIGSTNCANI LEWITKMLNN GGYHKMKPFV YKEAPFTRAF RASKVMKNVD 180
  181 PNVKRNIQTS IVNNLKSGVH WWALMALRQV MIPIVIKEER VLLWRDGYLN ILTKEIKDFK 240
  241 QRYIVQKAPH FIRPNVATFK LSISRQKLRP LFKRKAIDKK TETMQWKRLN SMLSWCLERS 300
  301 GVYRHTIRDS CKKVSDFLKK NSQNSKIIGY TADVSKCFST VNHDVLISII DRLFSQEHDI 360
  361 YTVCGKGRNH GGFHKLIFCS AGTELNAHEA LRRKMELKGV FNFEVCYREM SSSTTLYSVI 420
  421 RTTLSTYYYK RGPTSWRITK GVPQGHPISS NLAHMYLNNF EQKYWSNEKE DSRIVFCRYE 480
  481 DDFIFITTEN SLFEKMMKPL STGNNTHFLT ANPKKFKKSE RCGASQVLQW CGVKLDFQSG 540
  541 NCFIRRRCKD GVARQFLIKL Q

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..209] MSA 2.40998 View MSA. No confident structure predictions are available.
    2 View Details [210..274] deduced N/A No confident structure predictions are available.
    3 View Details [275..561] PSI-BLAST 12.045757 The crystal structure of the monomeric reverse transcriptase from Moloney murine leukemia virus

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • catalytic activity
    		•  0.518931870161593 bayes_pls_golite062009
  • transferase activity
    		•  0.35636561630516 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.32441153240842 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.29860211454192 bayes_pls_golite062009
  • DNA polymerase activity
    		•  0.0603497936698201 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  0.0602875211585996 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle