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Protein Overview: idh-2

General Information:
Name(s) found: idh-2 / CE15677 [WormBase]
Description(s) found:
Found 19 descriptions.
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  • WBGene00007942 locus:idh-2 Isocitrate dehydrogenase [NADP] status:Confirmed UniProt:O17643 protein_id:CAB03943.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 435 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: metabolic process [IEALink to PubMed article]
    Molecular Function: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [IEALink to PubMed article]
    isocitrate dehydrogenase (NADP+) activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSRLTSRNV LLARNVATAA TQERQKIKVD NPVVDLDGDE MTRIIWKEIK NKLILPYLDL  60
   61 DIKYYDLGLE YRDETNDQVT IDAAHAILEH SVGIKCATIT PDEARIKEFN LKKMWLSPNG 120
  121 TIRNILGGTV FREPILCKNI PRLVPGWTQP ITIGRHAFGD QYKCTDLVIP SGSTLQLLVN 180
  181 KPDGSKDVHN VYDFKKSGGV GLAMYNTDES IKGFAHSCFQ YALMKQWPLY LSTKNTILKK 240
  241 YDGRFKDIFQ DIYEKKYEAD FKNNKIWYEH RLIDDQVAQA LKSSGGFVWA CKNYDGDVQS 300
  301 DIVAQGYGSL GLMSSVLMCP DGKTIEAEAA HGTVTRHYRE HQKGNSTSTN PIASIFAWTR 360
  361 GLHHRGVLDN NEALKTFSLT LEKACIDTVE EGKMTKDLSI CIHGTKKGTE KGAYLITEDF 420
  421 LSAIDTKMAE LMRQD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..435] PSI-BLAST 135.0 NADP-dependent isocitrate dehydrogenase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • isocitrate dehydrogenase (NAD+) activity
    		•  5.9567768649084 bayes_pls_golite062009
  • isocitrate dehydrogenase activity
    		•  5.76817846591752 bayes_pls_golite062009
  • isocitrate dehydrogenase (NADP+) activity
    		•  3.47645456015586 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.74237430402883 bayes_pls_golite062009
  • catalytic activity
    		•  2.71251959637136 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  2.46799258909805 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  2.38235863668553 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  1.15484868227001 bayes_pls_golite062009
  • 3-isopropylmalate dehydrogenase activity
    		•  0.848289435089509 bayes_pls_golite062009
  • binding
    		•  0.530580225668688 bayes_pls_golite062009
  • protein binding
    		•  0.074256700284446 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.62

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle