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Protein Overview: top-1

General Information:
Name(s) found: top-1 / CE12284 [WormBase]
Description(s) found:
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  • WBGene00006595 locus:top-1 DNA topoisomerase 1 status:Confirmed UniProt:O17966 protein_id:CAB07639.1 [WormBase]
  • pir||T23647 hypothetical protein M01E5.5b - Caenorhabditis elegans [NCBI NR]
  • gi|71989170|ref|NP_001021578.1| TOPoisomerase family member (top-1) [Caenorhabditis elegans] [NCBI NR]
  • gi|3878631|emb|CAB07639.1| C. elegans protein M01E5.5b, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • [wormpep67.fasta]
  • CE12284 WBGene00006595 locus:top-1 DNA topoisomerase I status:Confirmed TR:O17965 protein_id:CAB07639.1 [wormpep150.fasta]
  • 12284 WBGene00006595 locus:top-1 DNA topoisomerase I status:Confirmed TR:O17965 protein_id:CAB07639.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • Hypothetical protein M01E5.5b [Caenorhabditis elegans]gi|7505887|pir||T23647 hypothetical protein M01E5.5b - Caenorhabditis elegans [nrdb_11152004_Chlamydomonas]
  • locus:top-1 DNA topoisomerase I status:Confirmed TR:O17965 protein_id:CAB07639.1 [wormpep115.fasta.reversed]
  • CE12284 DNA topoisomerase I status:Confirmed TR:O17965 protein_id:CAB07639.1 [wormpep80.hongbin]
  • CE12284 WBGene00006595 locus:top-1 DNA topoisomerase I status:Confirmed UniProt:TOP1_CAEEL protein_id:CAB07639.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE12284 WBGene00006595 locus:top-1 DNA topoisomerase I status:Confirmed UniProt:O17965_CAEEL protein_id:CAB07639.1| [wormORF-contam.fasta]
  • TOPoisomerase family member (top-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Hypothetical protein M01E5.5b [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE12284 WBGene00006595 locus:top-1 DNA topoisomerase I status:Confirmed UniProt:O17966 protein_id:CAB07639.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE12284 WBGene00006595 locus:top-1 status:Confirmed UniProt:O17966 protein_id:CAB07639.1 DNA topoisomerase 1 [wormpep246-ecoli-contam.fasta]
  • Isoform of O17966, Isoform b of DNA topoisomerase 1 OS=Caenorhabditis elegans GN=top-1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 734 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    spindle pole centrosome [IDALink to PubMed article]
    chromosome [IEALink to PubMed article]
    nucleolus [IDALink to PubMed article]
    Biological Process: molting cycle, protein-based cuticle [IMPLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed article]
    chromosome segregation [IMPLink to PubMed article]
    gamete generation [IMPLink to PubMed article]
    DNA topological change [IEALink to PubMed article]
    DNA unwinding involved in replication [IEALink to PubMed article]
    positive regulation of multicellular organism growth [IMPLink to PubMed article]
    growth [IMPLink to PubMed article]
    reproduction [IMPLink to PubMed article]
    oocyte construction [IMPLink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    gonad development [IMPLink to PubMed article]
    morphogenesis of an epithelium [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    Molecular Function: DNA binding [IEALink to PubMed article]
    DNA topoisomerase type I activity [IDALink to PubMed article][IEALink to PubMed article]
    DNA topoisomerase (ATP-hydrolyzing) activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVVSNHHSN GNGNSTVYDT NGNDEIKKEV KDEPMASDSE VPFGELMKRD KKEKKQKKRK  60
   61 AESGSDEDDY KPEKRKSSAK NGKKKDVGSD SEDDYKPEKK KSKKNNKKKA QESSEDDDEE 120
  121 SEGDVSEEDV KPQKRKSKGA EKSKPSTSKK DAGGKKEPPK KKVKKEEDIE DIWEWWKEEK 180
  181 KPAGVKWNSL QHCGPLFAPP YIPLPSHVHF KYGGEKMKLT LETEEIAQFY AGVLDHEYST 240
  241 KEAFNKNFMK DWRKVMTVEE RERIHDLKKC DFRAIDAYQK EQREIRKAMT KEEKLKIKEE 300
  301 KEAEVKIYGI AIIDGHRQKV ANFRIEPPGV FRGRGGHPKM GLIKKRIMPE DVIINCGKDT 360
  361 EIPKPPPGHK WKEVRHDNTV TWLCSWTESV LGQNKYIMLN PSSKIKGEKD FEKYETARRL 420
  421 KKKIGGIRER YTDDFKSKEM RVRQRATALY FIDKLALRAG NEKDVDEAAD TVGCCSLRVE 480
  481 HIKLFDSAKL NEDDKKEKEF VVEFDFLGKD SIRYFNRVSV EKRVYKNLKI FMEGKAPSDD 540
  541 LFDRLDTATL NDHLRSLMDG LTVKVFRTYN ASITLQEQLI KLTNPKDNVA AKILSYNRAN 600
  601 RQVAILCNHQ RAVSKGFDES MQKLEQKIKD KKKEVKEAEA ALKSARGAEK EKAQKKYDRL 660
  661 KEQLKKLKIS RTDKDENKQI ALGTSKLNYI DPRITVAWCK KFEVPLEKVF TKTHREKFRW 720
  721 AIDMTNSSDE EYVF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..171] FFAS03 1.32 No description for 2j63A was found.
    2 View Details [172..734] PSI-BLAST 1000.0 Eukaryotic DNA topoisomerase I, catalytic core; Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • DNA topoisomerase activity
    		•  8.60898665558163 bayes_pls_golite062009
  • DNA topoisomerase type I activity
    		•  6.47633260167335 bayes_pls_golite062009
  • isomerase activity
    		•  3.99087960186231 bayes_pls_golite062009
  • DNA binding
    		•  2.6219583041012 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.52094994351474 bayes_pls_golite062009
  • binding
    		•  2.48575835933363 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  2.2312769708203 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.791384719018446 bayes_pls_golite062009
  • chromatin binding
    		•  0.64398646193812 bayes_pls_golite062009
  • catalytic activity
    		•  0.609015643500883 bayes_pls_golite062009
  • protein binding
    		•  0.497523852978755 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle