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Protein Overview: fum-1

General Information:
Name(s) found: fum-1 / CE11580 [WormBase]
Description(s) found:
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  • WBGene00001503 locus:fum-1 Probable fumarate hydratase, mitochondrial status:Confirmed UniProt:O17214 protein_id:CCD72341.1 [WormBase]
  • gi|39931306|sp|O17214.1|FUMH_CAEEL RecName: Full=Probable fumarate hydratase, mitochondrial; Short=Fumarase; Flags: Precursor [NCBI NR]
  • pir||C88508 protein H14A12.2 [imported] - Caenorhabditis elegans [NCBI NR]
  • gi|2429444|gb|AAB70982.1| Fumarase protein 1, isoform a [Caenorhabditis elegans] [NCBI NR]
  • gi|17553882|ref|NP_498642.1| FUMarase family member (fum-1) [Caenorhabditis elegans] [NCBI NR]
  • Probable fumarate hydratase, mitochondrial OS=Caenorhabditis elegans GN=fum-1 PE=3 SV=1 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE11580 WBGene00001503 locus:fum-1 fumarase status:Partially_confirmed SW:O17214 protein_id:AAB70982.1 [wormpep150.fasta]
  • 11580 WBGene00001503 locus:fum-1 fumarase status:Partially_confirmed SW:O17214 protein_id:AAB70982.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • fumarate hydratase (3I555) [Caenorhabditis elegans]gi|2429444|gb|AAB70982.1| Fumarase protein 1, isoform a [Caenorhabditis elegans]gi|25291504|pir||C88508 protein H14A12.2 [imported] - Caenorhabditis elegansgi|39931306|sp|O17214|FUMH_CAEEL Putative fum [nrdb_11152004_Chlamydomonas]
  • locus:fum-1 fumarase status:Partially_confirmed TR:O17214 protein_id:AAB70982.1 [wormpep115.fasta.reversed]
  • CE11580 fumarase status:Partially_confirmed TR:O17214 protein_id:AAB70982.1 [wormpep80.hongbin]
  • CE11580 WBGene00001503 locus:fum-1 fumarase status:Partially_confirmed UniProt:O17214 protein_id:AAB70982.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE11580 WBGene00001503 locus:fum-1 fumarase status:Partially_confirmed UniProt:O17214 protein_id:AAB70982.1| [wormORF-contam.fasta]
  • FUMarase family member (fum-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Fumarase protein 1, isoform a [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Probable fumarate hydratase, mitochondrial precursor (Fumarase) [nr-271106-contam.fasta]
  • CE11580 WBGene00001503 locus:fum-1 fumarase status:Confirmed UniProt:O17214 protein_id:AAB70982.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE11580 WBGene00001503 locus:fum-1 fumarase status:Confirmed UniProt:O17214 protein_id:CCD72341.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE11580 WBGene00001503 locus:fum-1 status:Confirmed UniProt:O17214 protein_id:CCD72341.1 Probable fumarate hydratase, mitochondrial [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 501 amino acids

    Gene Ontology:
    Cellular Component: tricarboxylic acid cycle enzyme complex [IEALink to PubMed article]
    Biological Process: purine ribonucleotide biosynthetic process [IEALink to PubMed article]
    protocatechuate catabolic process [IEALink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed articleLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed article]
    arginine biosynthetic process via ornithine [IEALink to PubMed article]
    aspartate metabolic process [IEALink to PubMed article]
    fumarate metabolic process [IEALink to PubMed article]
    reproduction [IMPLink to PubMed article]
    Molecular Function: N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity [IEALink to PubMed article]
    3-carboxy-cis,cis-muconate cycloisomerase activity [IEALink to PubMed article]
    catalytic activity [IEALink to PubMed article]
    aspartate ammonia-lyase activity [IEALink to PubMed article]
    argininosuccinate lyase activity [IEALink to PubMed article]
    fumarate hydratase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAVSMLQGE MLARGGAVIA RGASLATARN FSRTTVPMAK IRKERDTFGE LEVPADKYYG  60
   61 AQTARSQMNF KIGGPEERMP IPVIHAFGIL KKAAALVNTE FGLDKKLADA ISQAADEVVD 120
  121 GKLDEHFPLV TWQTGSGTQS NMNVNEVISN RAIEILGGEL GSKKPVHPND HVNMSQSSND 180
  181 TFPTAMHIAV GREVNSRLLP ALKKLRTALH NKAEEFKDII KIGRTHTQDA VPLTLGQEFS 240
  241 AYVTQLDNSI ARVESTLPRL YQLAAGGTAV GTGLNTRKGF AEKVAATVSE LTGLPFVTAP 300
  301 NKFEALAAHD ALVEVHGALN TVAVSFMKIG NDIRFLGSGP RCGLGELSLP ENEPGSSIMP 360
  361 GKVNPTQCEA ITMVAAQVMG NQVAVSVGGS NGHFELNVFK PLIVRNVLQS TRLLADSAVS 420
  421 FTDHCVDGIV ANKDNIAKIM RESLMLVTAL NPHIGYDNAA KIAKTAHKNG TTLVQEAVKL 480
  481 GILTEEQFAQ WVKPENMLGP K

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..501] PSI-BLAST 157.0 RECOMBINANT YEAST FUMARASE

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • fumarate hydratase activity
    		•  4.22589182982073 bayes_pls_golite062009
  • catalytic activity
    		•  2.51282259572665 bayes_pls_golite062009
  • lyase activity
    		•  2.31268471569846 bayes_pls_golite062009
  • carbon-nitrogen lyase activity
    		•  2.2046475419807 bayes_pls_golite062009
  • histidine ammonia-lyase activity
    		•  0.948129236753279 bayes_pls_golite062009
  • amidine-lyase activity
    		•  0.901614580251298 bayes_pls_golite062009
  • binding
    		•  0.854855116369286 bayes_pls_golite062009
  • argininosuccinate lyase activity
    		•  0.617974375213548 bayes_pls_golite062009
  • ammonia-lyase activity
    		•  0.491229595527877 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.82

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle