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Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP. Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:, so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99). Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amide or amidine as a substrate.

View Gene Ontology (GO) Term


Name: N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
Acc: GO:0004018
Aspect: Molecular Function
Desc: Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP.
  • 6-N-(1,2-dicarboxyethyl)AMP AMP-lyase activity
  • N6-(1,2-dicarboxyethyl)AMP AMP-lyase activity
  • succino AMP-lyase activity
  • adenylosuccinase activity
  • adenylosuccinate lyase activity
Proteins in PDR annotated with:
   This term: 29 [Search]
   Term or descendants: 29 [Search]


GO:0004018 - N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity (interactive image map)

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