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Protein Overview: tig-2

General Information:
Name(s) found: tig-2 / CE10126 [WormBase]
Description(s) found:
Found 18 descriptions.
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  • WBGene00006570 locus:tig-2 status:Confirmed UniProt:O16273 protein_id:CCD65248.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 366 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: positive regulation of growth rate [IMP]
    growth [IEALink to PubMed article]
    Molecular Function: growth factor activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLFEFSILLG FLVPRGDSKG IYFVEERNGK TYTQPLTGQA TDKIGEQIRE LFNIDINPNG  60
   61 PAVKANNYVS TYMKRLYKQL ENYEHGENHN EEEVNAWLSA DRIVSHMAQE VSHRLDDGSY 120
  121 SIRFAKEHVP AKEGQSIVRA QLRIHIQGIV SPVFFYIEDT NLPGDTVLVS SDDPTVVTDV 180
  181 TTMVDRWSHL QLSTLPIVTA RASTNDELKI EAFLVIALKD EDAGPPKKRS RRSASTTPIS 240
  241 APPMRQKVKR SESAYFEKPN ENERCQRKGL YVDFDILGWK QWVIAPEGFS AFYCSGDCSA 300
  301 PFSKEMNATS HAIVQSTLHR VRPNSTTPAK CAPSSLGSYK ILFVDQNKQV QIKRYRDMVV 360
  361 DECGCH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..100] MSA 20.268996 View MSA. No confident structure predictions are available.
    2 View Details [101..231] MSA 8.390996 View MSA. No confident structure predictions are available.
    3 View Details [232..366] PSI-BLAST 41.0 BONE MORPHOGENETIC PROTEIN-7

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • type II transforming growth factor beta receptor binding
    		•  6.0109591386237 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  4.8369569327215 bayes_pls_golite062009
  • receptor binding
    		•  4.70889547404918 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
    		•  4.69128752159226 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  4.69128752159226 bayes_pls_golite062009
  • vascular endothelial growth factor receptor 1 binding
    		•  4.17375537569815 bayes_pls_golite062009
  • growth factor activity
    		•  4.01406832911234 bayes_pls_golite062009
  • cytokine activity
    		•  3.61376517935324 bayes_pls_golite062009
  • fibronectin binding
    		•  3.5904111848601 bayes_pls_golite062009
  • protein binding
    		•  3.57959800431189 bayes_pls_golite062009
  • binding
    		•  2.85157432803513 bayes_pls_golite062009
  • vascular endothelial growth factor receptor binding
    		•  2.76400237542695 bayes_pls_golite062009
  • vascular endothelial growth factor receptor 2 binding
    		•  2.68337714155403 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  2.49731836866959 bayes_pls_golite062009
  • platelet-derived growth factor receptor binding
    		•  2.45798835344627 bayes_pls_golite062009
  • glial cell line-derived neurotrophic factor receptor binding
    		•  2.42595321135263 bayes_pls_golite062009
  • growth factor binding
    		•  2.41942870726502 bayes_pls_golite062009
  • cell surface binding
    		•  2.33284053060339 bayes_pls_golite062009
  • heparin binding
    		•  2.11784489374422 bayes_pls_golite062009
  • hormone activity
    		•  1.83166472515554 bayes_pls_golite062009
  • protein dimerization activity
    		•  1.82426827198541 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.57604808199471 bayes_pls_golite062009
  • protein homodimerization activity
    		•  1.45915811604115 bayes_pls_golite062009
  • pattern binding
    		•  1.34327634476459 bayes_pls_golite062009
  • identical protein binding
    		•  1.32909205585546 bayes_pls_golite062009
  • platelet-derived growth factor binding
    		•  1.16893591942376 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.16191864095271 bayes_pls_golite062009
  • protein kinase activity
    		•  1.04675700066451 bayes_pls_golite062009
  • transcription activator activity
    		•  1.00293277340817 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.942223934173215 bayes_pls_golite062009
  • morphogen activity
    		•  0.91146826241391 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.88308874209284 bayes_pls_golite062009
  • neurotrophin receptor binding
    		•  0.81172494974121 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.638661528852015 bayes_pls_golite062009
  • vascular endothelial growth factor receptor 3 binding
    		•  0.385087890820529 bayes_pls_golite062009
  • transforming growth factor beta binding
    		•  0.332742217753928 bayes_pls_golite062009
  • catalytic activity
    		•  0.105223830172599 bayes_pls_golite062009
  • kinase activity
    		•  0.0830844256009901 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.0235054088545197 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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