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Protein Overview: gap-1

General Information:
Name(s) found: gap-1 / CE05002 [WormBase]
Description(s) found:
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  • WBGene00001515 locus:gap-1 Ras GTPase-activating protein gap-1 status:Confirmed UniProt:Q22720 protein_id:CCD71505.1 [WormBase]
  • pir||T34370 hypothetical protein T24C12.2 - Caenorhabditis elegans [NCBI NR]
  • gi|4249735|gb|AAD13781.1| GTPase activating protein GAP-1 [Caenorhabditis elegans] [NCBI NR]
  • gi|33112295|sp|Q22720.1|GAP1_CAEEL RecName: Full=Ras GTPase-activating protein gap-1; Short=GTPase-activating protein 1 [NCBI NR]
  • gi|17568363|ref|NP_508404.1| GTPase Activating Protein family member (gap-1) [Caenorhabditis elegans] [NCBI NR]
  • gi|1086756|gb|AAA82387.1| Gtpase activating protein family protein 1 [Caenorhabditis elegans] [NCBI NR]
  • Ras GTPase-activating protein gap-1 OS=Caenorhabditis elegans GN=gap-1 PE=2 SV=1 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE05002 WBGene00001515 locus:gap-1 GTPase activating protein (GAP) status:Confirmed SW:Q22720 protein_id:AAA82387.1 [wormpep150.fasta]
  • 05002 WBGene00001515 locus:gap-1 GTPase activating protein (GAP) status:Confirmed SW:Q22720 protein_id:AAA82387.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • SUpressor of Vulvaless SUV-1, GTPase Activating Protein (71.3 kD) (suv-1) [Caenorhabditis elegans]gi|1086756|gb|AAA82387.1| Gtpase activating protein family protein 1 [Caenorhabditis elegans]gi|4249735|gb|AAD13781.1| GTPase activating protein GAP-1 [Cae [nrdb_11152004_Chlamydomonas]
  • locus:gap-1 GTPase activating protein (GAP) status:Confirmed SW:Q22720 protein_id:AAA82387.1 [wormpep115.fasta.reversed]
  • CE05002 locus:gap-1 GTPase activating protein (GAP) status:Confirmed [wormpep80.hongbin]
  • CE05002 WBGene00001515 locus:gap-1 GTPase activating protein (GAP) status:Confirmed UniProt:Q22720 protein_id:AAA82387.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE05002 WBGene00001515 locus:gap-1 GTPase activating protein (GAP) status:Confirmed UniProt:Q22720 protein_id:AAA82387.1| [wormORF-contam.fasta]
  • GTPase Activating Protein family member (gap-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Ras GTPase-activating protein gap-1 (GTPase-activating protein 1) [nr-271106-contam.fasta]
  • Gtpase activating protein family protein 1 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • GTPase activating protein GAP-1 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE05002 WBGene00001515 locus:gap-1 GTPase activating protein (GAP) status:Confirmed UniProt:Q22720 protein_id:CCD71505.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE05002 WBGene00001515 locus:gap-1 status:Confirmed UniProt:Q22720 protein_id:CCD71505.1 Ras GTPase-activating protein gap-1 [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 629 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEALink to PubMed article]
    Biological Process: regulation of small GTPase mediated signal transduction [IEALink to PubMed article]
    Molecular Function: GTPase activator activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVLSCRVVDC GGLKLKENQT LLLLVSTIHN SSEVGKLSID AEEKRSKEWL EMPCAEGMLS  60
   61 LKLTLWQDLL KGINSVFHGQ VRVDVDENWK SGPAKWFYLR SKANEDGEGG EDGGDIGDAT 120
  121 VKVTYQIDHI LRMQVYKPLL DLLFLAGDVQ PLTASLVAVI EALPKVELGP VSRSLVELMA 180
  181 QSDRIRPVLS SLYVNSILKC QDENTLFRGQ SLSGKMLFEI LTTYGKMYLI TTLKPVVDKI 240
  241 YKERKNCEVD PARVAVGASL EKNRNNLLVY FQMLFERVTT SSTNCPHLIK QLLYDLRNVV 300
  301 GTHSSRSGVQ RLAVSSFVIM RFFAAAILNP KAFEIRKDQP DLRVSRTLLL LSKLLQRLSN 360
  361 CSVSEGPLSS KEIWLNGVFE TVTSEQHKSV MASFLDNISL VGDRSEPQKC TVFKFGNLQQ 420
  421 VDRSRLAWKK VLHYKKRYVQ LTNTHLIWQK DVQCAPKGTV PLSDIKFVNV DNKNIITIVC 480
  481 ETMQLQFEAP GGVEATDWLN AIERQRNRAA HEIAETPGEH FFVDAERHVD KIHTLLYKYR 540
  541 ETMIEWRDQL QSNVELDEKT APELLKASYV VEEERQSHKD SLIATLCSTI DVTDAIQLAH 600
  601 TEYEKENKVS RRIDAIITAK KRQKSFSVK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..149] PSI-BLAST 21.522879 Synaptogamin I
    2 View Details [150..457] PSI-BLAST 35.221849 GAP related domain of neurofibromin
    3 View Details [458..522] PSI-BLAST 14.522879 Tapp1
    4 View Details [523..629] MSA 2.263997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • GTPase regulator activity
    		•  5.23789256375467 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  5.21562004568462 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  4.91645234075732 bayes_pls_golite062009
  • GTPase activator activity
    		•  4.81440293338491 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  4.76400460221691 bayes_pls_golite062009
  • Rho GTPase activator activity
    		•  4.58620967349979 bayes_pls_golite062009
  • enzyme regulator activity
    		•  4.5322075775333 bayes_pls_golite062009
  • Rac GTPase activator activity
    		•  4.48279904625182 bayes_pls_golite062009
  • enzyme activator activity
    		•  4.29367232260052 bayes_pls_golite062009
  • binding
    		•  1.62780792681766 bayes_pls_golite062009
  • protein binding
    		•  1.21496582666968 bayes_pls_golite062009
  • GTPase binding
    		•  0.42172811061186 bayes_pls_golite062009
  • small GTPase binding
    		•  0.238166011641691 bayes_pls_golite062009
    3
    Term Confidence Notes
  • binding
    		•  2.65091781683225 bayes_pls_golite062009
  • protein binding
    		•  2.12168271674167 bayes_pls_golite062009
  • GTPase regulator activity
    		•  1.66986263418539 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  1.64990514605397 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  1.2550809703725 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.25381967078645 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  0.745321902095093 bayes_pls_golite062009
  • small GTPase binding
    		•  0.721546282992641 bayes_pls_golite062009
  • GTPase binding
    		•  0.70180064264191 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle