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View Structure Prediction Details

Protein: gap-1
Organism: Caenorhabditis elegans
Length: 629 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gap-1.

Description E-value Query
Range
Subject
Range
gi|114650811 - gi|114650811|ref|XP_509751.2| PREDICTED: RAS p21 protein activator 3 [Pan troglodytes]
365.0 [0..2] [618..521]

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Predicted Domain #1
Region A:
Residues: [1-149]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVLSCRVVDC GGLKLKENQT LLLLVSTIHN SSEVGKLSID AEEKRSKEWL EMPCAEGMLS  60
   61 LKLTLWQDLL KGINSVFHGQ VRVDVDENWK SGPAKWFYLR SKANEDGEGG EDGGDIGDAT 120
  121 VKVTYQIDHI LRMQVYKPLL DLLFLAGDV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.522879
Match: 1dqvA
Description: Synaptogamin I
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [150-457]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPLTASLVAV IEALPKVELG PVSRSLVELM AQSDRIRPVL SSLYVNSILK CQDENTLFRG  60
   61 QSLSGKMLFE ILTTYGKMYL ITTLKPVVDK IYKERKNCEV DPARVAVGAS LEKNRNNLLV 120
  121 YFQMLFERVT TSSTNCPHLI KQLLYDLRNV VGTHSSRSGV QRLAVSSFVI MRFFAAAILN 180
  181 PKAFEIRKDQ PDLRVSRTLL LLSKLLQRLS NCSVSEGPLS SKEIWLNGVF ETVTSEQHKS 240
  241 VMASFLDNIS LVGDRSEPQK CTVFKFGNLQ QVDRSRLAWK KVLHYKKRYV QLTNTHLIWQ 300
  301 KDVQCAPK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.221849
Match: 1nf1A
Description: GAP related domain of neurofibromin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
GTPase regulator activity 5.23789256375467 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 5.21562004568462 bayes_pls_golite062009
small GTPase regulator activity 4.91645234075732 bayes_pls_golite062009
GTPase activator activity 4.81440293338491 bayes_pls_golite062009
Ras GTPase activator activity 4.76400460221691 bayes_pls_golite062009
Rho GTPase activator activity 4.58620967349979 bayes_pls_golite062009
enzyme regulator activity 4.5322075775333 bayes_pls_golite062009
Rac GTPase activator activity 4.48279904625182 bayes_pls_golite062009
enzyme activator activity 4.29367232260052 bayes_pls_golite062009
binding 1.62780792681766 bayes_pls_golite062009
protein binding 1.21496582666968 bayes_pls_golite062009
GTPase binding 0.42172811061186 bayes_pls_golite062009
small GTPase binding 0.238166011641691 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [458-522]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTVPLSDIKF VNVDNKNIIT IVCETMQLQF EAPGGVEATD WLNAIERQRN RAAHEIAETP  60
   61 GEHFF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.522879
Match: 1eazA
Description: Tapp1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.65091781683225 bayes_pls_golite062009
protein binding 2.12168271674167 bayes_pls_golite062009
GTPase regulator activity 1.66986263418539 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 1.64990514605397 bayes_pls_golite062009
small GTPase regulator activity 1.2550809703725 bayes_pls_golite062009
enzyme regulator activity 1.25381967078645 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 0.745321902095093 bayes_pls_golite062009
small GTPase binding 0.721546282992641 bayes_pls_golite062009
GTPase binding 0.70180064264191 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [523-629]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VDAERHVDKI HTLLYKYRET MIEWRDQLQS NVELDEKTAP ELLKASYVVE EERQSHKDSL  60
   61 IATLCSTIDV TDAIQLAHTE YEKENKVSRR IDAIITAKKR QKSFSVK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle