Protein Overview: gap-1

General Information:
Name(s) found:	gap-1 / CE05002 [WormBase]
Description(s) found: Found 22 descriptions. SHOW ALL	WBGene00001515 locus:gap-1 Ras GTPase-activating protein gap-1 status:Confirmed UniProt:Q22720 protein_id:CCD71505.1 [WormBase]
Organism:	Caenorhabditis elegans
Length:	629 amino acids
Gene Ontology:
Cellular Component:	intracellular [IEA]
Biological Process:	regulation of small GTPase mediated signal transduction [IEA]
Molecular Function:	GTPase activator activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVLSCRVVDC GGLKLKENQT LLLLVSTIHN SSEVGKLSID AEEKRSKEWL EMPCAEGMLS  60
   61 LKLTLWQDLL KGINSVFHGQ VRVDVDENWK SGPAKWFYLR SKANEDGEGG EDGGDIGDAT 120
  121 VKVTYQIDHI LRMQVYKPLL DLLFLAGDVQ PLTASLVAVI EALPKVELGP VSRSLVELMA 180
  181 QSDRIRPVLS SLYVNSILKC QDENTLFRGQ SLSGKMLFEI LTTYGKMYLI TTLKPVVDKI 240
  241 YKERKNCEVD PARVAVGASL EKNRNNLLVY FQMLFERVTT SSTNCPHLIK QLLYDLRNVV 300
  301 GTHSSRSGVQ RLAVSSFVIM RFFAAAILNP KAFEIRKDQP DLRVSRTLLL LSKLLQRLSN 360
  361 CSVSEGPLSS KEIWLNGVFE TVTSEQHKSV MASFLDNISL VGDRSEPQKC TVFKFGNLQQ 420
  421 VDRSRLAWKK VLHYKKRYVQ LTNTHLIWQK DVQCAPKGTV PLSDIKFVNV DNKNIITIVC 480
  481 ETMQLQFEAP GGVEATDWLN AIERQRNRAA HEIAETPGEH FFVDAERHVD KIHTLLYKYR 540
  541 ETMIEWRDQL QSNVELDEKT APELLKASYV VEEERQSHKD SLIATLCSTI DVTDAIQLAH 600
  601 TEYEKENKVS RRIDAIITAK KRQKSFSVK

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..149]	PSI-BLAST	21.522879	Synaptogamin I
2	View Details	[150..457]	PSI-BLAST	35.221849	GAP related domain of neurofibromin
3	View Details	[458..522]	PSI-BLAST	14.522879	Tapp1
4	View Details	[523..629]	MSA	2.263997	View MSA. No confident structure predictions are available.

Functions predicted (by domain):

#

Gene Ontology predictions

1

No functions predicted.

2

Term	Confidence	Notes
GTPase regulator activity	5.23789256375467	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	5.21562004568462	bayes_pls_golite062009
small GTPase regulator activity	4.91645234075732	bayes_pls_golite062009
GTPase activator activity	4.81440293338491	bayes_pls_golite062009
Ras GTPase activator activity	4.76400460221691	bayes_pls_golite062009
Rho GTPase activator activity	4.58620967349979	bayes_pls_golite062009
enzyme regulator activity	4.5322075775333	bayes_pls_golite062009
Rac GTPase activator activity	4.48279904625182	bayes_pls_golite062009
enzyme activator activity	4.29367232260052	bayes_pls_golite062009
binding	1.62780792681766	bayes_pls_golite062009
protein binding	1.21496582666968	bayes_pls_golite062009
GTPase binding	0.42172811061186	bayes_pls_golite062009
small GTPase binding	0.238166011641691	bayes_pls_golite062009

3

Term	Confidence	Notes
binding	2.65091781683225	bayes_pls_golite062009
protein binding	2.12168271674167	bayes_pls_golite062009
GTPase regulator activity	1.66986263418539	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	1.64990514605397	bayes_pls_golite062009
small GTPase regulator activity	1.2550809703725	bayes_pls_golite062009
enzyme regulator activity	1.25381967078645	bayes_pls_golite062009
guanyl-nucleotide exchange factor activity	0.745321902095093	bayes_pls_golite062009
small GTPase binding	0.721546282992641	bayes_pls_golite062009
GTPase binding	0.70180064264191	bayes_pls_golite062009

4

No functions predicted.

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.92

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle