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Protein Overview: rpa-1

General Information:
Name(s) found: rpa-1 / CE04405 [WormBase]
Description(s) found:
Found 23 descriptions.
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  • WBGene00017546 locus:rpa-1 Probable replication factor A 73 kDa subunit status:Confirmed UniProt:Q19537 protein_id:CCD62042.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 655 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article][IEALink to PubMed article]
    Biological Process: DNA replication [IEALink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    Molecular Function: nucleic acid binding [IEALink to PubMed article]
    DNA binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAIHINHDV FNKYHTNGKL RLTTGYVQEA IENNGYPGHD GIVQVLKGKV EQGEQLGHAF  60
   61 TFRIRISDGV FQYNALMSAD IDDQIKREVE HLVEGTIIAL TKFEIYDQGE GAKNCFLIKG 120
  121 YKILSRYHQV LTSPEVKPRS HSGKPDEHKG YRPNIIIEDV WPEAEGMAAD YQENMANPPA 180
  181 AKAPKREFGE EASYNRAAAP EATRARAVPP PARRTASNTE RGVMPIAMVT PYVSNFKIHG 240
  241 MVSRKEEIRT FPAKNTKVFN FEITDSNGDT IRCTAFNEVA ESLYTTITEN LSYYLSGGSV 300
  301 KQANKKFNNT GHDYEITLRS DSIIEAGGEL LAAPKLILKR VKLGEIAGYA GQLIDVLVVV 360
  361 EKMDPEATEF TSKAGKSLIK REMELIDESG ALVRLTLWGD EATKALVDDY VQKVIAFKGV 420
  421 IPREFNGGFS LGTGSATRII SVPEIAGVSE LYDWYANVKP TTEVKMMSQA AGGSNEAPRT 480
  481 IAGLQEMQFG KDSDKGDYAT VKAMITRVNP TNALYRGCAS EGCQKKLVGE NGDYRCEKCN 540
  541 KNMNKFKWLY MMQFELSDET GQVYVTAFGD SAAKIVGKSA AELGELHDES PDEYNAIFER 600
  601 LQFVPKMWRL RCKMDSYNEE VRQKMTVYGV DDVNQDKYIE NLKQMIEQMQ QMSDY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-1 hcp1 IP from december2004 Cheeseman, I.M., et al. (2005)
    View Run hcp-2 hcp2 ip from december Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..216] PSI-BLAST 29.39794 N-terminal domain of the RPA70 subunit of human replication protein A.
    2 View Details [217..470] PSI-BLAST 55.0 Replication protein A 70 KDa subunit (RPA70)
    3 View Details [471..655] PSI-BLAST 46.0 Replication protein A 70 KDa subunit (RPA70)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.05826047136716 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.359779538637606 bayes_pls_golite062009
    2
    Term Confidence Notes
  • binding
    		•  1.05826047136716 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.359779538637606 bayes_pls_golite062009
    3
    Term Confidence Notes
  • binding
    		•  1.05826047136716 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.359779538637606 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle