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Protein Overview: nth-1

General Information:
Name(s) found: nth-1 / CE03559 [WormBase]
Description(s) found:
Found 19 descriptions.
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  • WBGene00011201 locus:nth-1 endonuclease status:Partially_confirmed UniProt:P54137 protein_id:CAA90766.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 259 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEALink to PubMed article]
    Biological Process: DNA repair [IEALink to PubMed article]
    base-excision repair [IEALink to PubMed article]
    Molecular Function: DNA binding [IEALink to PubMed article]
    endonuclease activity [IEALink to PubMed article]
    DNA-(apurinic or apyrimidinic site) lyase activity [IEALink to PubMed article]
    DNA N-glycosylase activity [IEALink to PubMed article]
    4 iron, 4 sulfur cluster binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRKDMIAPVD TMGCHKLADP LAAPPVHRFQ VLVALMLSSQ TRDEVNAAAM KRLKDHGLSI  60
   61 GKILEFKVPD LETILCPVGF YKRKAVYLQK TAKILKDDFS GDIPDSLDGL CALPGVGPKM 120
  121 ANLVMQIAWG ECVGIAVDTH VHRISNRLGW IKTSTPEKTQ KALEILLPKS EWQPINHLLV 180
  181 GFGQMQCQPV RPKCGTCLCR FTCPSSTAKN VKSETEETST SIEVKQEVED EFEDEKPAKK 240
  241 IKKTRKTRTK IEVKTESET

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..259] PSI-BLAST 59.69897 REFINEMENT OF THE NATIVE STRUCTURE OF ENDONUCLEASE III TO A RESOLUTION OF 1.85 ANGSTROM

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA N-glycosylase activity
    		•  4.08559331236111 bayes_pls_golite062009
  • hydrolase activity, hydrolyzing N-glycosyl compounds
    		•  3.73234184319832 bayes_pls_golite062009
  • DNA-(apurinic or apyrimidinic site) lyase activity
    		•  3.12421941323765 bayes_pls_golite062009
  • hydrolase activity, acting on glycosyl bonds
    		•  2.54759386266723 bayes_pls_golite062009
  • catalytic activity
    		•  2.50389926428623 bayes_pls_golite062009
  • oxidized base lesion DNA N-glycosylase activity
    		•  1.80199518353554 bayes_pls_golite062009
  • alkylbase DNA N-glycosylase activity
    		•  1.75218522602775 bayes_pls_golite062009
  • hydrolase activity
    		•  1.39000450534744 bayes_pls_golite062009
  • DNA-3-methyladenine glycosylase I activity
    		•  1.14337995879633 bayes_pls_golite062009
  • oxidized purine base lesion DNA N-glycosylase activity
    		•  0.473206156100251 bayes_pls_golite062009
  • uracil DNA N-glycosylase activity
    		•  0.29478804124408 bayes_pls_golite062009
  • oxidized pyrimidine base lesion DNA N-glycosylase activity
    		•  0.253198605718519 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle