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Protein Overview: idh-1

General Information:
Name(s) found: idh-1 / CE03436 [WormBase]
Description(s) found:
Found 19 descriptions.
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  • WBGene00010317 locus:idh-1 Isocitrate dehydrogenase [NADP] status:Confirmed UniProt:Q21032 protein_id:CAA92778.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 412 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: metabolic process [IEALink to PubMed article]
    Molecular Function: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [IEALink to PubMed article]
    isocitrate dehydrogenase (NADP+) activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAQKIQGGD IVEMQGDEMT RIIWDLIKEK LILPYVDLNV HFFDLGIEHR DATDDQVTID  60
   61 AANATLKYNV AVKCATITPD EARVEEFKLK KMWKSPNGTI RNILGGTVFR EPIIVKNVPR 120
  121 LVNTWSKPII IGRHAHADQY KATDFVVPGA GKLEIKFVSA DGTQTIQETV FDFKGPGVSL 180
  181 SMYNTDDSIR DFAHASFKYA LQRKFPLYLS TKNTILKKYD GRFKDIFAEI YPEYEAEFKA 240
  241 AGIWYEHRLI DDMVAQAMKS DGGFVWACKN YDGDVQSDSV AQGYGSLGLM TSVLVCPDGK 300
  301 TVEAEAAHGT VTRHYRMHQK GQETSTNPIA SIFAWSRGLA HRATLDKNSA LETFANNLEA 360
  361 VCIETMEAGF LTKDLAICVK GGNASAVTRT DYLNTFEFLD KLAENLAKKQ AH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..412] PSI-BLAST 122.0 Crystal structure of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex NADP

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • isocitrate dehydrogenase (NAD+) activity
    		•  5.9567768649084 bayes_pls_golite062009
  • isocitrate dehydrogenase activity
    		•  5.76817846591752 bayes_pls_golite062009
  • isocitrate dehydrogenase (NADP+) activity
    		•  3.47645456015586 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.74237430402883 bayes_pls_golite062009
  • catalytic activity
    		•  2.71251959637136 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  2.46799258909805 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  2.38235863668553 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  1.15484868227001 bayes_pls_golite062009
  • 3-isopropylmalate dehydrogenase activity
    		•  0.848289435089509 bayes_pls_golite062009
  • binding
    		•  0.530580225668688 bayes_pls_golite062009
  • protein binding
    		•  0.074256700284446 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle