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Protein Overview: sphk-1

General Information:
Name(s) found: sphk-1 / CE03053 [WormBase]
Description(s) found:
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  • WBGene00007918 locus:sphk-1 Sphingosine kinase 1 status:Partially_confirmed UniProt:Q18425 protein_id:CAA91259.1 [WormBase]
  • pir||T19707 hypothetical protein C34C6.5 - Caenorhabditis elegans [NCBI NR]
  • gi|71983700|ref|NP_001022017.1| SPHingosine Kinase family member (sphk-1) [Caenorhabditis elegans] [NCBI NR]
  • gi|3874710|emb|CAA91259.1| C. elegans protein C34C6.5a, partially confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • ref|NP_495847.1| sphingosine kinase (2I990) [Caenorhabditis elegans] [NCBI NR]
  • Sphingosine kinase 1 OS=Caenorhabditis elegans GN=sphk-1 PE=1 SV=1 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE03053 WBGene00007918 locus:tag-274 Diacylglycerol kinase catalytic domain (presumed) status:Partially_confirmed TR:Q18425 protein_id:CAA91259.1 [wormpep150.fasta]
  • 03053 WBGene00007918 Diacylglycerol kinase catalytic domain (presumed) status:Predicted TR:Q18425 protein_id:CAA91259.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • sphingosine kinase (2I990) [Caenorhabditis elegans]gi|3874710|emb|CAA91259.1| Hypothetical protein C34C6.5a [Caenorhabditis elegans]gi|7496992|pir||T19707 hypothetical protein C34C6.5 - Caenorhabditis elegans [nrdb_11152004_Chlamydomonas]
  • CE03053 WBGene00007918 Diacylglycerol kinase catalytic domain (presumed) status:Predicted TR:Q18425 protein_id:CAA91259.1 [wormpep132.fasta]
  • 03053 WBGene00007918 locus:tag-274 Diacylglycerol kinase catalytic domain (presumed) status:Partially_confirmed TR:Q18425 protein_id:CAA91259.1 [wormpep150-phg-orf-ecoli-rand.fasta]
  • CE03053 WBGene00007918 Diacylglycerol kinase catalytic domain (presumed) status:Partially_confirmed TR:Q18425 protein_id:CAA91259.1 [WormBase_C-elegans_na_01-20-2005_combined_reversed.fasta]
  • Diacylglycerol kinase catalytic domain (presumed) status:Partially_confirmed TR:Q18425 protein_id:CAA91259.1 [wormpep115.fasta.reversed]
  • CE03053 Diacylglycerol kinase catalytic domain (presumed) status:Predicted TR:Q18425 protein_id:CAA91259.1 [wormpep80.hongbin]
  • CE03053 WBGene00007918 locus:sphk-1 Diacylglycerol kinase catalytic domain (presumed) status:Partially_confirmed UniProt:Q18425_CAEEL protein_id:CAA91259.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE03053 WBGene00007918 locus:sphk-1 Diacylglycerol kinase catalytic domain (presumed) status:Partially_confirmed UniProt:Q18425_CAEEL protein_id:CAA91259.1| [wormORF-contam.fasta]
  • Temporarily Assigned Gene name family member (tag-274) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Hypothetical protein C34C6.5a [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE03053 WBGene00007918 locus:sphk-1 Diacylglycerol kinase catalytic domain (presumed) status:Partially_confirmed UniProt:Q18425 protein_id:CAA91259.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE03053 WBGene00007918 locus:sphk-1 status:Partially_confirmed UniProt:Q18425 protein_id:CAA91259.1 Sphingosine kinase 1 [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 473 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway [IEALink to PubMed article]
    Molecular Function: diacylglycerol kinase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFIVVVTIFE NYTQWYSSLL TIFSLTIKRK LKTIRSMQDS TSKCTCTEHH MGGTICCCCR  60
   61 SDAEENEQLT SVILSRKPPP QEQCRGNLLV FINPNSGTGK SLETFANTVG PKLDKSLIRY 120
  121 EVVVTTGPNH ARNVLMTKAD LGKFNGVLIL SGDGLVFEAL NGILCREDAF RIFPTLPIGI 180
  181 VPSGSGNGLL CSVLSKYGTK MNEKSVMERA LEIATSPTAK AESVALYSVK TDNQSYASFL 240
  241 SIGWGLMADI DIDSEKWRKS LGHHRFTVMG FIRSCNLRSY KGRLTYRPYK PKGFHPSSNV 300
  301 FSVYEKTTQQ RIDDSKVKTN GSVSDSEEET METKFQNWTL PDSDETLAVG SSDLEETVVI 360
  361 EDNFVNIYAV TLSHIAADGP FAPSAKLEDN RIHLSYILWK DIGTRVNIAK YLLAIEHETH 420
  421 LDLPFVKHVE VSSMKLEVIS EGSHVVLDGE VVDTKTIEVA STKNHISVFS STA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..83] PSI-BLAST 3.69897 Solution Structure of The C1 Domain of The Human Diacylglycerol Kinase Delta
    2 View Details [84..387] PSI-BLAST 30.522879 No description for 2bonA was found.
    3 View Details [388..473] FFAS03 2.31 No description for 2bonA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • diacylglycerol kinase activity
    		•  2.90473448739823 bayes_pls_golite062009
  • binding
    		•  2.36195429973813 bayes_pls_golite062009
  • protein binding
    		•  2.34145982999922 bayes_pls_golite062009
  • GTPase regulator activity
    		•  1.39167263636091 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.38342442442381 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  1.37139209958305 bayes_pls_golite062009
  • kinase activity
    		•  1.33864137110482 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.33317387103526 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.1573242399369 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.911061212692491 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  0.907368864863833 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.826306657093297 bayes_pls_golite062009
  • transferase activity
    		•  0.758542436038668 bayes_pls_golite062009
  • DNA binding
    		•  0.717144137601851 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  0.661240850692236 bayes_pls_golite062009
  • protein kinase activity
    		•  0.565178270477957 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.50008268869921 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.418610537312063 bayes_pls_golite062009
  • transcription factor activity
    		•  0.201999701332224 bayes_pls_golite062009
  • catalytic activity
    		•  0.194464246602439 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.0643193071226404 bayes_pls_golite062009
    2
    Term Confidence Notes
  • kinase activity
    		•  2.76633393386992 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.49560915337842 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.43985991144271 bayes_pls_golite062009
  • transferase activity
    		•  1.63159199531284 bayes_pls_golite062009
  • catalytic activity
    		•  0.33446102778142 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.89

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle