Protein Overview: ehs-1

General Information:
Name(s) found:	ehs-1 / CE02903 [WormBase]
Description(s) found: Found 17 descriptions. SHOW ALL	WBGene00001224 locus:ehs-1 status:Confirmed UniProt:Q23418 protein_id:AAC71084.1 [WormBase]
Organism:	Caenorhabditis elegans
Length:	751 amino acids
Gene Ontology:
Cellular Component:	synapse [IMP] axon [IMP]
Biological Process:	synaptic vesicle endocytosis [IMP] synaptic transmission [IMP]
Molecular Function:	protein binding [TAS] calcium ion binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPVLGQIWEL SDSQKVGSLD KRGAFVAFKL VAAAQQGKPV ANSSLYDSSL QPPRFAPPVP  60
   61 PANMQHHFQP SFPSVGRAPP VPPPPHPSHP YSISSQQSSP AHPSSAFPPQ WPITPTDQAK 120
  121 YDSIFQSLNP VNGKLSGAHV RPVLMNSGLD AHALARIWEL SDQDKDGNLD RIEMSVALHL 180
  181 VYRSLQSDPV PAQLPPNLIH PSKAMYAHSS PNFAAPPHPP RPMMGSRAGS VTSLDDVNMS 240
  241 QSYSATMPRA YPPQPGRAYS AQAHVNGSRT SGASTPISAS HSIHSFPAGE WPINTGDYAD 300
  301 QFAQTDTNKD GLVDGMDMRA PMMTTGLSAQ ILAHVWALAD IKKCGQLNLE QFALTMHLLD 360
  361 MAKRGESIPS ELPLHLIPPS FRPPTEPSAL HHPAQSVSTP QLPEATSMEI KEALEGENEE 420
  421 MKQLAESIQS MLVERKTAEE AVLQLEADMT IKNSSIKNLQ VELATLESTV KQLERQKGEA 480
  481 TRRLADYDTQ IEQLESACKA QKETKEDTEK RMQQIDEDAK NAEDCKANDE KEMEELKKEI 540
  541 EMLDNQFKTV RGEIVKETSQ REQKVAELTT LERKEARDQI QMEKLDAAIE NTTKLTEQVS 600
  601 DAVEKSEEEM VQILRSQQRL LSTVIDQSLL SDDTVYGETA GTSSQNHVQQ PPDPFASARA 660
  661 NPAADPFAQV DQFGSSGHFD AAFPTDPFAQ GGFPSDSGFA QSAPAKPAPP RPAPPKSARE 720
  721 TPVNDPFAPS QGQSTQPAGF ADFADFGSAF N

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	hcp-2	hcp2 ip from december	Cheeseman, I.M., et al. (2005)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..98]	PSI-BLAST	13.522879	Eps15
2	View Details	[99..239]	PSI-BLAST	28.045757	STRUCTURE OF THE SECOND EPS15 HOMOLOGY DOMAIN OF HUMAN EPS15, NMR, 20 STRUCTURES
3	View Details	[240..595]	PSI-BLAST	43.154902	Heavy meromyosin subfragment
4	View Details	[596..685]	PSI-BLAST	13.09691	Tropomyosin
5	View Details	[686..751]	deduced	N/A	No confident structure predictions are available.

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
binding	2.38779497247992	bayes_pls_golite062009
protein binding	1.36984860219682	bayes_pls_golite062009
calcium ion binding	1.21855083755727	bayes_pls_golite062009
transporter activity	1.15928534291452	bayes_pls_golite062009
cytoskeletal protein binding	1.01146756530391	bayes_pls_golite062009
transmembrane transporter activity	0.945691505472547	bayes_pls_golite062009
signal transducer activity	0.933783050059916	bayes_pls_golite062009
molecular transducer activity	0.933783050059916	bayes_pls_golite062009
ion binding	0.669548940693197	bayes_pls_golite062009
cation binding	0.668563425093018	bayes_pls_golite062009
metal ion binding	0.668563425093018	bayes_pls_golite062009
actin binding	0.514092416982902	bayes_pls_golite062009
substrate-specific transporter activity	0.438908712437433	bayes_pls_golite062009
active transmembrane transporter activity	0.246383459363256	bayes_pls_golite062009
structural constituent of muscle	0.235603681531933	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.20908131617536	bayes_pls_golite062009

2

Term	Confidence	Notes
binding	2.38779497247992	bayes_pls_golite062009
protein binding	1.36984860219682	bayes_pls_golite062009
calcium ion binding	1.21855083755727	bayes_pls_golite062009
transporter activity	1.15928534291452	bayes_pls_golite062009
cytoskeletal protein binding	1.01146756530391	bayes_pls_golite062009
transmembrane transporter activity	0.945691505472547	bayes_pls_golite062009
signal transducer activity	0.933783050059916	bayes_pls_golite062009
molecular transducer activity	0.933783050059916	bayes_pls_golite062009
ion binding	0.669548940693197	bayes_pls_golite062009
cation binding	0.668563425093018	bayes_pls_golite062009
metal ion binding	0.668563425093018	bayes_pls_golite062009
actin binding	0.514092416982902	bayes_pls_golite062009
substrate-specific transporter activity	0.438908712437433	bayes_pls_golite062009
active transmembrane transporter activity	0.246383459363256	bayes_pls_golite062009
structural constituent of muscle	0.235603681531933	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.20908131617536	bayes_pls_golite062009

3

No functions predicted.

4

No functions predicted.

5

No functions predicted.

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle