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View Structure Prediction Details

Protein: ehs-1
Organism: Caenorhabditis elegans
Length: 751 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ehs-1.

Description E-value Query
Range		 Subject
Range
CE44947 - WBGene00001224 locus:ehs-1 status:Confirmed UniProt:Q9BIF4 protein_id:CCD72519.1
 330.0 [0..1] [751..46]

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Predicted Domain #1
Region A:
Residues: [1-98] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPVLGQIWEL SDSQKVGSLD KRGAFVAFKL VAAAQQGKPV ANSSLYDSSL QPPRFAPPVP  60
   61 PANMQHHFQP SFPSVGRAPP VPPPPHPSHP YSISSQQS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.522879
Match: 1qjtA
Description: Eps15
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.38779497247992 bayes_pls_golite062009
protein binding 1.36984860219682 bayes_pls_golite062009
calcium ion binding 1.21855083755727 bayes_pls_golite062009
transporter activity 1.15928534291452 bayes_pls_golite062009
cytoskeletal protein binding 1.01146756530391 bayes_pls_golite062009
transmembrane transporter activity 0.945691505472547 bayes_pls_golite062009
signal transducer activity 0.933783050059916 bayes_pls_golite062009
molecular transducer activity 0.933783050059916 bayes_pls_golite062009
ion binding 0.669548940693197 bayes_pls_golite062009
cation binding 0.668563425093018 bayes_pls_golite062009
metal ion binding 0.668563425093018 bayes_pls_golite062009
actin binding 0.514092416982902 bayes_pls_golite062009
substrate-specific transporter activity 0.438908712437433 bayes_pls_golite062009
active transmembrane transporter activity 0.246383459363256 bayes_pls_golite062009
structural constituent of muscle 0.235603681531933 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.20908131617536 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [99-239] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPAHPSSAFP PQWPITPTDQ AKYDSIFQSL NPVNGKLSGA HVRPVLMNSG LDAHALARIW  60
   61 ELSDQDKDGN LDRIEMSVAL HLVYRSLQSD PVPAQLPPNL IHPSKAMYAH SSPNFAAPPH 120
  121 PPRPMMGSRA GSVTSLDDVN M

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 28.045757
Match: 1eh2A
Description: STRUCTURE OF THE SECOND EPS15 HOMOLOGY DOMAIN OF HUMAN EPS15, NMR, 20 STRUCTURES
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.38779497247992 bayes_pls_golite062009
protein binding 1.36984860219682 bayes_pls_golite062009
calcium ion binding 1.21855083755727 bayes_pls_golite062009
transporter activity 1.15928534291452 bayes_pls_golite062009
cytoskeletal protein binding 1.01146756530391 bayes_pls_golite062009
transmembrane transporter activity 0.945691505472547 bayes_pls_golite062009
signal transducer activity 0.933783050059916 bayes_pls_golite062009
molecular transducer activity 0.933783050059916 bayes_pls_golite062009
ion binding 0.669548940693197 bayes_pls_golite062009
cation binding 0.668563425093018 bayes_pls_golite062009
metal ion binding 0.668563425093018 bayes_pls_golite062009
actin binding 0.514092416982902 bayes_pls_golite062009
substrate-specific transporter activity 0.438908712437433 bayes_pls_golite062009
active transmembrane transporter activity 0.246383459363256 bayes_pls_golite062009
structural constituent of muscle 0.235603681531933 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.20908131617536 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [240-595] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQSYSATMPR AYPPQPGRAY SAQAHVNGSR TSGASTPISA SHSIHSFPAG EWPINTGDYA  60
   61 DQFAQTDTNK DGLVDGMDMR APMMTTGLSA QILAHVWALA DIKKCGQLNL EQFALTMHLL 120
  121 DMAKRGESIP SELPLHLIPP SFRPPTEPSA LHHPAQSVST PQLPEATSME IKEALEGENE 180
  181 EMKQLAESIQ SMLVERKTAE EAVLQLEADM TIKNSSIKNL QVELATLEST VKQLERQKGE 240
  241 ATRRLADYDT QIEQLESACK AQKETKEDTE KRMQQIDEDA KNAEDCKAND EKEMEELKKE 300
  301 IEMLDNQFKT VRGEIVKETS QREQKVAELT TLERKEARDQ IQMEKLDAAI ENTTKL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.154902
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [596-685] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TEQVSDAVEK SEEEMVQILR SQQRLLSTVI DQSLLSDDTV YGETAGTSSQ NHVQQPPDPF  60
   61 ASARANPAAD PFAQVDQFGS SGHFDAAFPT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.09691
Match: 2tmaA
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [686-751] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPFAQGGFPS DSGFAQSAPA KPAPPRPAPP KSARETPVND PFAPSQGQST QPAGFADFAD  60
   61 FGSAFN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle