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Protein Overview: ptp-2

General Information:
Name(s) found: ptp-2 / CE02705 [WormBase]
Description(s) found:
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  • WBGene00004214 locus:ptp-2 Tyrosine-protein phosphatase non-receptor type status:Confirmed UniProt:G5EC24 protein_id:CCD70155.1 [WormBase]
  • pir||T34317 protein-tyrosine-phosphatase (EC 3.1.3.48) PTP-2, nonreceptor type 6/11 [validated] - Caenorhabditis elegans [NCBI NR]
  • gi|2323370|gb|AAC21678.1| protein tyrosine phosphatase [Caenorhabditis elegans] [NCBI NR]
  • gi|17535377|ref|NP_495184.1| Protein Tyrosine Phosphatase family member (ptp-2) [Caenorhabditis elegans] [NCBI NR]
  • gi|13592435|gb|AAK31531.1| Protein tyrosine phosphatase protein 2 [Caenorhabditis elegans] [NCBI NR]
  • Tyrosine-protein phosphatase non-receptor type ptp-2 OS=Caenorhabditis elegans GN=ptp-2 PE=1 SV=1 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE02705 WBGene00004214 locus:ptp-2 PROTEIN-TYROSINE PHOSPHATASE status:Confirmed TR:Q21055 protein_id:AAK31531.1 [wormpep150.fasta]
  • 02705 WBGene00004214 locus:ptp-2 PROTEIN-TYROSINE PHOSPHATASE status:Confirmed TR:Q21055 protein_id:AAK31531.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • protein tyrosine phosphatase, non-receptor type, has 2 SH2 domains; participates in signal transduction during oogenesis and vulval development, STerile Progeny STP-1 (76.7 kD) (ptp-2) [Caenorhabditis elegans]gi|13592435|gb|AAK31531.1| Protein tyrosine p [nrdb_11152004_Chlamydomonas]
  • locus:ptp-2 PROTEIN-TYROSINE PHOSPHATASE status:Confirmed TR:Q21055 protein_id:AAK31531.1 [wormpep115.fasta.reversed]
  • CE02705 locus:ptp-2 PROTEIN-TYROSINE PHOSPHATASE status:Confirmed [wormpep80.hongbin]
  • CE02705 WBGene00004214 locus:ptp-2 PROTEIN-TYROSINE PHOSPHATASE status:Confirmed UniProt:Q21055_CAEEL protein_id:AAK31531.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE02705 WBGene00004214 locus:ptp-2 PROTEIN-TYROSINE PHOSPHATASE status:Confirmed UniProt:Q21055_CAEEL protein_id:AAK31531.1| [wormORF-contam.fasta]
  • Protein tyrosine phosphatase protein 2 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Protein Tyrosine Phosphatase family member (ptp-2) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • protein tyrosine phosphatase [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE02705 WBGene00004214 locus:ptp-2 PROTEIN-TYROSINE PHOSPHATASE status:Confirmed UniProt:Q21055 protein_id:AAK31531.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE02705 WBGene00004214 locus:ptp-2 PROTEIN-TYROSINE PHOSPHATASE status:Confirmed UniProt:G5EC24 protein_id:CCD70155.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE02705 WBGene00004214 locus:ptp-2 status:Confirmed UniProt:G5EC24 protein_id:CCD70155.1 Tyrosine-protein phosphatase non-receptor type [wormpep246-ecoli-contam.fasta]
  • Tyrosine-protein phosphatase non-receptor type OS=Caenorhabditis elegans GN=ptp-2 PE=1 SV=1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 668 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    Biological Process: muscle organ development [IMPLink to PubMed article]
    positive regulation of vulval development [IGILink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    oogenesis [IMPLink to PubMed article]
    nematode larval development [IGILink to PubMed article]
    signal transduction [IEALink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed article]
    protein amino acid dephosphorylation [IEALink to PubMed article]
    positive regulation of epidermal growth factor receptor signaling pathway [IGILink to PubMed article]
    positive regulation of Ras protein signal transduction [IGILink to PubMed article]
    regulation of cell projection organization [IMPLink to PubMed article]
    dephosphorylation [IEALink to PubMed article]
    Molecular Function: ATP binding [IEALink to PubMed article]
    non-membrane spanning protein tyrosine kinase activity [IEALink to PubMed article]
    protein tyrosine phosphatase activity [IEALink to PubMed article]
    phosphatase activity [IEALink to PubMed article]
    cytoskeletal protein binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPRLALRQYN FYYRVNGEKA EELLKEYGED GDFLLRYSES NPQNFSISVR VAEDKILHIK  60
   61 VTKYESDMLS IFEDERTTPN QFGSITELAE FYMEFPEKLR EKNGLFLELK KPVYVPYHLE 120
  121 ACAEEQRRTQ LYRWWHGNLP ASSANKLLQT EKNGTYLLRA SQHIPGALVI SAKTEGQVVH 180
  181 LTIYQDPSTG RFNIDGDRTK FQSAWLLIDS YSKNPIVEKG EASRVLYLEE PLFNTFIEAD 240
  241 LFVDRFEIIR RPINPRESME KTGISEEFDR LSQEALPAEQ YLSKREGRRP VNAEKNRYKN 300
  301 IVPFDHTRVI LTDRPNTPGS DYINASYVRF ENSQRTKNVT FACEKSFIAT QGCLETTISD 360
  361 FWSMVWQENS RVIVMPTMEN ERKEKCARYW PAEVNKPEVH GDISLTCTIE RKVQRAVSDE 420
  421 VKAELEQEKT NRIAKGLVPE AELNGDGISY ILRTLVMKKG KDTREIRQLQ YLTWPDHGCP 480
  481 LHPYAVLNFL EDVDREYDYF NAQPIAASLP QGPIVVHCSA GIGRTGTVLV LDALLNQVKK 540
  541 VGLLCPMDVY KMVKYVRTYR SGLVQTEQQY QFLYKALAFY LKNNNPYPVK SFIDGDTDAF 600
  601 DFPRRLRPTP NASRPSSARQ VTSSRPSSSA SSRTSHSRPR TGPQAEPIFE RSTSSTSSSS 660
  661 TLLKSTKK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..587] PSI-BLAST 96.522879 Crystal structure of human tyrosine phosphatase SHP-1
    2 View Details [588..668] PSI-BLAST 89.69897 Crystal structure of the phosphatase domains of human PTP SIGMA


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle