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Protein Overview: pab-2

General Information:
Name(s) found: pab-2 / CE02193 [WormBase]
Description(s) found:
Found 19 descriptions.
SHOW ALL
  • WBGene00003903 locus:pab-2 status:Confirmed UniProt:Q19579 protein_id:CAA90444.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 692 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    Biological Process: mRNA processing [IEALink to PubMed article]
    Molecular Function: nucleic acid binding [IEALink to PubMed article]
    RNA binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQVPPPMTQ VVTSAPPPTA AATVVAGAVA GQPQAVIQQG PPPTNIGYPP NATYSMASLY  60
   61 IGDLHPDVSE AMLFEKFSMA GPVLSIRVCR DNTSRLSLGY AYVNFQQPAD AERALDTMNF 120
  121 EVIHGRPMRI MWSQRDPAAR RAGNGNIFIK NLDRVIDNKS VYDTFSLFGN ILSCKVATDD 180
  181 EGNSKGYGFV HFETEHSAQT AIEKVNGMLL SDKKVYVGKF QPRAQRMKEL GESGLKYTNV 240
  241 FVKNFGEHLD QEKLSAMFSK FGEITSAVVM TDAQGKPKGF GFVAFADQDA AGQAVEKLND 300
  301 SILEGTDCKL SVCRAQKKSE RSAELKRKYE ALKQERVQRY QGVNLYVKNI EEDLNDDGLR 360
  361 DHFSSFGTIT SAKVMVDENG RSKGFGFVCF EKPEEATAAV TDMNSKMIGA KPLYVALAQR 420
  421 KEDRRAQLAS QYMQRLATLR MGQQASGVPA MTQLYQPGQQ GYFVPNPMNA QGRPGFQPQS 480
  481 AQIRGPPGQR VFQNQMFMQY PFNQRQVYPQ QQGRPPMRTN DGRPQYGMAP RPAGAPRVGG 540
  541 PGVQMGGAPI RQQGPAPRGA PQKPFYQGPP RQQQPQQHSQ QPAQQPGQQG QGQSGIVIHG 600
  601 QETLTSHMLA QAAPQEQKQL LGERIYALIE KMFPNHKEAG KITGMMLEID NAELIMMLQD 660
  661 AELFRSKVEE AFGVLTNAQS AAASTSAPTA KN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-2 hcp2 ip from december Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..235] PSI-BLAST 54.30103 Poly(A)-binding protein
    2 View Details [236..329] PSI-BLAST 13.522879 Polypyrimidine tract-binding protein
    3 View Details [330..449] FFAS03 4.79 NMR solution structure of TcUBP1, a single RBD-unit from Trypanosoma cruzi
    4 View Details [450..614] PSI-BLAST 4.154902 Sec24
    5 View Details [615..692] PSI-BLAST 29.221849 poly(A) binding protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA binding
    		•  6.73097473547076 bayes_pls_golite062009
    		• 6.62953239642182 bayes_pls_golite062009
  • mRNA binding
    		•  5.29759606920196 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.92126426323641 bayes_pls_golite062009
  • snRNA binding
    		•  4.06596327298973 bayes_pls_golite062009
  • binding
    		•  3.64400841800969 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  3.11990160533699 bayes_pls_golite062009
  • U1 snRNA binding
    		•  3.02511982045347 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  2.93798024346416 bayes_pls_golite062009
  • poly(U) RNA binding
    		•  2.49013736906028 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.18211199677674 bayes_pls_golite062009
  • protein binding
    		•  2.17260848225967 bayes_pls_golite062009
  • DNA binding
    		•  1.98418556946403 bayes_pls_golite062009
  • hydrolase activity
    		•  1.59923957614061 bayes_pls_golite062009
  • structural molecule activity
    		•  1.56454315220334 bayes_pls_golite062009
  • U2 snRNA binding
    		•  1.34078165372485 bayes_pls_golite062009
  • transcription factor activity
    		•  1.07843408116687 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.06887262556449 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.824614388276642 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.632534695085793 bayes_pls_golite062009
  • eukaryotic initiation factor 4G binding
    		•  0.597542453741953 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.383589644462932 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.100880394187931 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.0459458211377304 bayes_pls_golite062009
  • receptor binding
    		•  0.00911566774455674 bayes_pls_golite062009
    2
    Term Confidence Notes
  • RNA binding
    		•  6.73097473547076 bayes_pls_golite062009
    		• 6.62953239642182 bayes_pls_golite062009
  • mRNA binding
    		•  5.29759606920196 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.92126426323641 bayes_pls_golite062009
  • snRNA binding
    		•  4.06596327298973 bayes_pls_golite062009
  • binding
    		•  3.64400841800969 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  3.11990160533699 bayes_pls_golite062009
  • U1 snRNA binding
    		•  3.02511982045347 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  2.93798024346416 bayes_pls_golite062009
  • poly(U) RNA binding
    		•  2.49013736906028 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.18211199677674 bayes_pls_golite062009
  • protein binding
    		•  2.17260848225967 bayes_pls_golite062009
  • DNA binding
    		•  1.98418556946403 bayes_pls_golite062009
  • hydrolase activity
    		•  1.59923957614061 bayes_pls_golite062009
  • structural molecule activity
    		•  1.56454315220334 bayes_pls_golite062009
  • U2 snRNA binding
    		•  1.34078165372485 bayes_pls_golite062009
  • transcription factor activity
    		•  1.07843408116687 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.06887262556449 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.824614388276642 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.632534695085793 bayes_pls_golite062009
  • eukaryotic initiation factor 4G binding
    		•  0.597542453741953 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.383589644462932 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.100880394187931 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.0459458211377304 bayes_pls_golite062009
  • receptor binding
    		•  0.00911566774455674 bayes_pls_golite062009
    3
    Term Confidence Notes
    		• 6.40066880991253 bayes_pls_golite062009
  • RNA binding
    		•  6.32219487559982 bayes_pls_golite062009
  • mRNA binding
    		•  4.87640532914983 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.65259034341669 bayes_pls_golite062009
  • snRNA binding
    		•  3.77997752511163 bayes_pls_golite062009
  • binding
    		•  3.48033873254013 bayes_pls_golite062009
  • U1 snRNA binding
    		•  2.73908382552928 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  2.7133834347239 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  2.55628738360472 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.2045206027152 bayes_pls_golite062009
  • poly(U) RNA binding
    		•  2.13305841145089 bayes_pls_golite062009
  • protein binding
    		•  2.10850948869511 bayes_pls_golite062009
  • DNA binding
    		•  1.99030664201171 bayes_pls_golite062009
  • hydrolase activity
    		•  1.62800695894716 bayes_pls_golite062009
  • structural molecule activity
    		•  1.57342338925793 bayes_pls_golite062009
  • transcription factor activity
    		•  1.09958329302628 bayes_pls_golite062009
  • U2 snRNA binding
    		•  1.09350203162237 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.07516027015942 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.633093884585572 bayes_pls_golite062009
  • eukaryotic initiation factor 4G binding
    		•  0.468183942177665 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.462558743683805 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.327072171076297 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.0991482775217878 bayes_pls_golite062009
  • receptor binding
    		•  0.0174485064798613 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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