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Protein Overview: prs-1

General Information:
Name(s) found: prs-1 / CE00748 [WormBase]
Description(s) found:
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  • WBGene00004189 locus:pars-1 status:Confirmed UniProt:Q22620 protein_id:CCD73349.1 [WormBase]
  • pir||T16915 hypothetical protein T20H4.3 - Caenorhabditis elegans [NCBI NR]
  • gi|71991342|ref|NP_001022777.1| Prolyl tRNA Synthetase family member (prs-1) [Caenorhabditis elegans] [NCBI NR]
  • gi|459009|gb|AAA50660.1| Prolyl trna synthetase protein 1, isoform a [Caenorhabditis elegans] [NCBI NR]
  • ref|NP_498596.1| prolyl tRNA synthetase (65.8 kD) (prs-1) [Caenorhabditis elegans] [NCBI NR]
  • [wormpep67.fasta]
  • CE00748 WBGene00004189 locus:prs-1 Prolyl-tRNA synthetase region status:Partially_confirmed TR:Q22620 protein_id:AAA50660.1 [wormpep150.fasta]
  • 00748 WBGene00004189 locus:prs-1 Prolyl-tRNA synthetase region status:Partially_confirmed TR:Q22620 protein_id:AAA50660.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • prolyl tRNA synthetase (65.8 kD) (prs-1) [Caenorhabditis elegans]gi|459009|gb|AAA50660.1| Prolyl trna synthetase protein 1, isoform a [Caenorhabditis elegans]gi|7508084|pir||T16915 hypothetical protein T20H4.3 - Caenorhabditis elegans [nrdb_11152004_Chlamydomonas]
  • locus:prs-1 Prolyl-tRNA synthetase region status:Partially_confirmed TR:Q22620 protein_id:AAA50660.1 [wormpep115.fasta.reversed]
  • CE00748 locus:prs-1 Prolyl-tRNA synthetase region status:Partially_confirmed [wormpep80.hongbin]
  • CE00748 WBGene00004189 locus:prs-1 Prolyl-tRNA synthetase region status:Confirmed UniProt:Q22620_CAEEL protein_id:AAA50660.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE00748 WBGene00004189 locus:prs-1 Prolyl-tRNA synthetase region status:Confirmed UniProt:Q22620_CAEEL protein_id:AAA50660.1| [wormORF-contam.fasta]
  • Prolyl trna synthetase protein 1, isoform a [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Prolyl tRNA Synthetase family member (prs-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE00748 WBGene00004189 locus:prs-1 Prolyl-tRNA synthetase region status:Confirmed TR:Q22620 protein_id:AAA50660.1 [WormBase_C-elegans_wp180_08-19-2007_reversed.fasta]
  • CE00748 WBGene00004189 locus:prs-1 Prolyl-tRNA synthetase region status:Confirmed UniProt:Q22620 protein_id:AAA50660.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE00748 WBGene00004189 locus:pars-1 Prolyl-tRNA synthetase region status:Confirmed UniProt:Q22620 protein_id:CCD73349.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE00748 WBGene00004189 locus:pars-1 status:Confirmed UniProt:Q22620 protein_id:CCD73349.1 [wormpep246-ecoli-contam.fasta]
  • Prolyl Amino-acyl tRNA Synthetase OS=Caenorhabditis elegans GN=pars-1 PE=1 SV=1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 581 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    Biological Process: tRNA aminoacylation for protein translation [IEALink to PubMed article]
    nematode larval development [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed article]
    prolyl-tRNA aminoacylation [IEALink to PubMed article]
    growth [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    reproduction [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    translation [IEALink to PubMed article]
    Molecular Function: nucleotide binding [IEALink to PubMed article]
    ATP binding [IEALink to PubMed article]
    aminoacyl-tRNA ligase activity [IEALink to PubMed article]
    proline-tRNA ligase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTKEEITKE IEEQGAEVRR VKGDKNSTEE AKKEAIDKLL ALKLTYKEVT GQEYAAPNAR  60
   61 QSKPKKEEKP KQQPKQQEKK QDGKKQTLLG VGTKKDDNYS EWYSEVITKA EMIEYYDVSG 120
  121 CYVLRPWSFA VWESIQEWFD SGIKKLGVKN CYFPMFVSNA ALEREKTHIA DFAPEVAWVT 180
  181 RAGNSEMAEP IAIRPTSETV MYPSYKKWVQ SHRDLPIKLN QWCNVVRWEF KHPTPFLRTR 240
  241 EFLWQEGHTA FANPADAEKE VFQILDLYAG VYTDLLAIPV VKGRKSEKEK FAGGDFTTTV 300
  301 EAYVACNGRG IQGATSHHLG QNFSKMFDIS YEDPAKEGER AFAWQNSWGL STRTIGAMVM 360
  361 IHGDDKGLVL PPRVAAVQVI VVPVGFKTEN KQSLFDAVDK VTKDLVADGV KAEHDLRENY 420
  421 NAGWKFNHWE LKGVPIRFEV GPNDLAKNQV TAVIRHNGEK KQLSLEGLSK TVKSLLDEIH 480
  481 TAMYNKVLAQ RDSHLKSTTC IEEFKKLLDE KCIILSPFCG RPDCEEEIKK ASTREDGEGA 540
  541 QMGAKTLCIP LDQPKQELPS KCLFPSCTYN AKAFALFGRS Y

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..91] PSI-BLAST 97.154902 Structure of Staphylococcus aureus threonyl-tRNA synthetase complexed with an analogue of threonyl adenylate
    2 View Details [92..581] PSI-BLAST 104.0 Prolyl-tRNA synthetase (ProRS) domain; C-terminal domain of ProRS; Prolyl-tRNA synthetase (ProRS)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • proline-tRNA ligase activity
    		•  7.40793503200657 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  5.35865531372193 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  5.35865531372193 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  5.34613366014959 bayes_pls_golite062009
  • ligase activity
    		•  4.40567333287149 bayes_pls_golite062009
  • phenylalanine-tRNA ligase activity
    		•  1.82630084735103 bayes_pls_golite062009
  • serine-tRNA ligase activity
    		•  1.67995723068335 bayes_pls_golite062009
  • threonine-tRNA ligase activity
    		•  1.61348476813499 bayes_pls_golite062009
  • histidine-tRNA ligase activity
    		•  1.44658852946316 bayes_pls_golite062009
  • alanine-tRNA ligase activity
    		•  1.37855221028045 bayes_pls_golite062009
  • catalytic activity
    		•  1.27293510281823 bayes_pls_golite062009
  • lysine-tRNA ligase activity
    		•  1.2286808923607 bayes_pls_golite062009
  • glycine-tRNA ligase activity
    		•  1.22845858760023 bayes_pls_golite062009
  • asparagine-tRNA ligase activity
    		•  0.50755166961092 bayes_pls_golite062009
  • binding
    		•  0.398946779962706 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle