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Protein Overview: cku-80

General Information:
Name(s) found: cku-80 / CE00660 [WormBase]
Description(s) found:
Found 18 descriptions.
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  • WBGene00000520 locus:cku-80 status:Partially_confirmed UniProt:Q21829 protein_id:CAA83623.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 728 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    DNA-dependent protein kinase-DNA ligase 4 complex [IEALink to PubMed article]
    Biological Process: DNA recombination [IEALink to PubMed article]
    double-strand break repair via nonhomologous end joining [IEALink to PubMed article]
    Molecular Function: DNA binding [IEALink to PubMed article]
    ATP-dependent DNA helicase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPKKVSPGI TVILIDAGSN MSVKDTETGK SAFENAINAA DWIVSRKLFS KDPELFSVMA  60
   61 YNLDPKEYKT EVGGQTFNGV QCQNEKFTPA SFDHLKFITK ELQQNTEMID PNFFKGVLGA 120
  121 VAVLKDQIES YPNPSGITLI VLTNGLNENI RQENFDLLVE AVSESNADLM IIGIDENPEY 180
  181 PASRVAELAE TLEGRTYTFQ NVAKMLSTFQ ARQKSERKYN KMWDIAPGIH LPVIFALKSE 240
  241 KSTALLKFKN ADSEGNEMVR LEQMHVETDE VAPKDEFKSP VLEEKPKFQK NFKPVENIKT 300
  301 MHGSEILNFL KSIINASGYN FGKSVIMMDP EYLKEKYNDH NFNEGQTGGV LKLIQFTKRA 360
  361 NILDSYLLDA SAKTVLPALN SPKSGATKAT VSLIEAMLSL RVAAICRYTF HAKSHVQLIA 420
  421 LLPHQDEETG VFYLRSVKLP FSDDMRTLKF PKFSFDEEDE DLNKPTVAQL SAVDDLIDCM 480
  481 QLQEDEISSL VEGGMSDPKL QMQCHFLKSL VLHPNDTFEN HSNRTNQILD QIMAPKRRVE 540
  541 AEHPEIFQKL GREFNLQPIQ KTKRERVTVE PEDLQTMISE WTEKKQNMTQ PDEVDDGASQ 600
  601 KKKKKPNAKK LTRKEEVQMD IMEDGGASRV CSKILEMISN TCKFQPNGAV TEFFTLLVNE 660
  661 LNVIRSVFVE NSKCDEFNEL LKKLKDEEDF EPFAEVLSEE KSCNPIDSSE VSMSEVSVAN 720
  721 AAEFWEED

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-1 hcp1 IP from december2004 Cheeseman, I.M., et al. (2005)
    View Run hcp-2 hcp2 ip from december Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..614] PSI-BLAST 95.522879 DNA binding C-terminal domain of ku70; Ku70 subunit
    2 View Details [615..728] PSI-BLAST 37.69897 Three-dimensional structure of Ku80 CTD

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  0.0650247416983729 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.85

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle