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Protein Overview: CE00136

General Information:
Name(s) found: CE00136 [WormBase]
Description(s) found:
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  • WBGene00008514 Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial status:Confirmed UniProt:P34385 protein_id:CAA79618.1 [WormBase]
  • gi|465847|sp|P34385.1|MCCB_CAEEL RecName: Full=Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial; Short=MCCase subunit beta; AltName: Full=3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta; AltName: Full=3-methylcrotonyl-CoA carboxy [NCBI NR]
  • gi|3875448|emb|CAA79618.1| C. elegans protein F02A9.4a, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • pir||S28313 hypothetical protein F02A9.5 - Caenorhabditis elegans [NCBI NR]
  • gi|17552936|ref|NP_499013.1| hypothetical protein F02A9.4 [Caenorhabditis elegans] [NCBI NR]
  • Hypothetical protein F02A9.4a in chromosome III - Caenorhabditis elegans [Swiss-Prot]
  • Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial precursor - Caenorhabditis elegans [Swiss-Prot]
  • Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial OS=Caenorhabditis elegans GN=F02A9.4 PE=3 SV=1 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE00136 WBGene00008514 Propionyl-CoA carboxylase status:Confirmed SW:P34385 protein_id:CAA79618.1 [wormpep150.fasta]
  • 00136 WBGene00008514 Propionyl-CoA carboxylase status:Confirmed SW:P34385 protein_id:CAA79618.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • acyl-CoA carboxyltransferase (66.5 kD) (3K174) [Caenorhabditis elegans]gi|3875448|emb|CAA79618.1| Hypothetical protein F02A9.4a [Caenorhabditis elegans]gi|280542|pir||S28313 hypothetical protein F02A9.5 - Caenorhabditis elegansgi|465847|sp|P34385|YLPC_ [nrdb_11152004_Chlamydomonas]
  • Propionyl-CoA carboxylase status:Partially_confirmed SW:P34385 protein_id:CAA79618.1 [wormpep115.fasta.reversed]
  • CE00136 Propionyl-CoA carboxylase status:Partially_confirmed SW:P34385 protein_id:CAA79618.1 [wormpep80.hongbin]
  • CE00136 WBGene00008514 Propionyl-CoA carboxylase status:Confirmed UniProt:P34385 protein_id:CAA79618.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE00136 WBGene00008514 Propionyl-CoA carboxylase status:Confirmed UniProt:P34385 protein_id:CAA79618.1| [wormORF-contam.fasta]
  • Hypothetical protein F02A9.4a in chromosome III [nr-271106-contam.fasta]
  • Hypothetical protein F02A9.4a [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • F02A9.4a [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE00136 WBGene00008514 status:Confirmed UniProt:P34385 protein_id:CAA79618.1 Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 608 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: sodium ion transport [IEALink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed article]
    RNA processing [IEALink to PubMed article]
    growth [IMPLink to PubMed article]
    Molecular Function: RNA binding [IEALink to PubMed article]
    ribonuclease III activity [IEALink to PubMed article]
    methylmalonyl-CoA decarboxylase activity [IEALink to PubMed article]
    ligase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFRHVAQNLG SRNTSIQSYR LLRTRWERGY LKDLYHRRQI LGADPAISRS SYPNCSVQVR  60
   61 NHHCSADKST LQWAPIKTSI DNSSDDFAAN TAEMKVLVED LKAKISKIEQ AGGEKAVKLH 120
  121 RSRGKMLARE RIDGIVDAGS PFIEFSQLAG YEMYGKEEVP SGGILTGVGI VSGRVCVIVA 180
  181 NDATVKGGTY YPITVKKHLR AQEIARENKL PCIYLVDSGG ANLPRQADIF ADSQHFGRIF 240
  241 YNQATMSSEG IPQLAVVMGS CTAGGAYVPA MSDQAIIVKG TGTVFLGGPP LVKAATGEEI 300
  301 SAEELGGADL HCGESGVTDY YAHNDKHALY LARSCIAGLP PVEEHMTFNP NADEPLYPAE 360
  361 EIYGIVGSNL KKTYDVREVI ARIVDGSRFH EFKERYGETL VTGFATIYGQ RVGILANNGV 420
  421 LFAESAMKGS HFIELCCQRK IPLLFLQNIT GFMVGRDAEA GGIAKHGAKL VTAVACAKVP 480
  481 KITVLVGGSY GAGNYGMCGR GYSPRYVFMW PNSRISVMGG EQAANVLSTV QKEKKKREGA 540
  541 DWTDQQDLEL RKPVEEKFEK EGHPYFASAR LWDDGVIDPK DTRKVLGLAF QSTLQKPIPE 600
  601 TKFGVFRM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..76] PSI-BLAST 3.39794 No description for 2d5dA was found.
    2 View Details [77..608] PSI-BLAST 149.0 Crystal structure of propionyl-CoA carboxylase, beta subunit (TM0716) from THERMOTOGA MARITIMA at 2.30 A resolution

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • CoA carboxylase activity
    		•  4.38629333084302 bayes_pls_golite062009
  • acetyl-CoA carboxylase activity
    		•  4.36332808516753 bayes_pls_golite062009
  • ligase activity, forming carbon-carbon bonds
    		•  4.29345455730254 bayes_pls_golite062009
  • enoyl-CoA hydratase activity
    		•  3.92947460544831 bayes_pls_golite062009
  • methylcrotonoyl-CoA carboxylase activity
    		•  2.85169024122548 bayes_pls_golite062009
  • 3-hydroxyacyl-CoA dehydrogenase activity
    		•  2.44182589784656 bayes_pls_golite062009
  • dodecenoyl-CoA delta-isomerase activity
    		•  1.80820904754223 bayes_pls_golite062009
  • catalytic activity
    		•  1.46154163027498 bayes_pls_golite062009
  • propionyl-CoA carboxylase activity
    		•  1.20853698666984 bayes_pls_golite062009
  • ligase activity
    		•  0.98581896521131 bayes_pls_golite062009
  • binding
    		•  0.578223105269736 bayes_pls_golite062009
  • 3-hydroxybutyryl-CoA epimerase activity
    		•  0.241955774397835 bayes_pls_golite062009
  • racemase and epimerase activity, acting on hydroxy acids and derivatives
    		•  0.099208209617217 bayes_pls_golite062009
  • intramolecular oxidoreductase activity, transposing C=C bonds
    		•  0.0918189681606029 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle