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Protein Overview: hri2

General Information:
Name(s) found: hri2 / SPAC222.07c [Sanger Pombe]
Description(s) found:
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  • gi|74698447|sp|Q9UTE5.1|E2AK2_SCHPO RecName: Full=Eukaryotic translation initiation factor 2-alpha kinase 2; AltName: Full=Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase; AltName: Full=Heme-regulated inhibitor 2 [NCBI NR]
  • gi|6433992|emb|CAB60699.1| eIF2 alpha kinase Hri2 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|22653430|gb|AAN04054.1| eIF2 kinase Hri2p [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19114058|ref|NP_593146.1| eIF2 alpha kinase Hri2 [Schizosaccharomyces pombe] [NCBI NR]
  • pir||T50148 probable ser/thr protein kinase [imported] - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • eIF2 alpha kinase Hri2 [Sanger Pombe]
  • Eukaryotic translation initiation factor 2-alpha kinase 2 OS=Schizosaccharomyces pombe GN=hri2 PE=1 SV=1 [Swiss-Prot]
  • PUTATIVE HEME REGULATED EUKARYOTIC INITIATION FACTOR BY SIMILAR TO MOUSE HRI AND OTHERS; EIF-2-ALPHA KINASE; SERINE/THREONINE PROTEIN KINASE: Q9UTE5; [pompepVF.fasta]
  • PUTATIVE HEME REGULATED EUKARYOTIC INITIATION FACTOR BY SIMILARITY TO MOUSE HRI AND OTHERS; EIF-2-ALPHA KINASE; SERINE/THREONINE PROTEIN KINASE: Q9UTE5; [pompepV13]
  • eIF2 kinase Hri2p [pompep4896]
  • |hri2||serine/threonine protein kinase [pompepnew.fasta]
  • EIF2 kinase Hri2p (Hri2 protein) (Spac222.07c protein) [4896.FASTAC]
  • |hri2||serine/threonine protein kinase|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • putative ser/thr protein kinase [Schizosaccharomyces pombe]gi|22653430|gb|AAN04054.1| eIF2 kinase Hri2p [Schizosaccharomyces pombe]gi|6433992|emb|CAB60699.1| SPAC222.07c [Schizosaccharomyces pombe]gi|11359273|pir||T50148 probable ser/thr protein kinase [nrdb_11152004_Chlamydomonas]
  • |hri2||eIF2alpha kinase family Hri1p|Schizosaccharomyces pombe|chr 1|||Manual [pompep2242005.fasta]
  • (Q9UTE5) eIF2 kinase Hri2p [pompep4896_normal_reversed]
  • |hri2||eIF2 alpha kinase Hri2|Schizosaccharomyces pombe|chr 1|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • eIF2 kinase Hri2p [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • SPAC222.07c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • Eukaryotic translation initiation factor 2-alpha kinase 2 (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor 2) [nr-271106-contam.fasta]
  • hypothetical protein SPAC222.07c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • Eukaryotic translation initiation factor 2-alpha kinase 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=hri2 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 639 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDALink to PubMed article]
    Biological Process: cellular response to stress [IMPLink to PubMed article]
    negative regulation of translational initiation in response to stress [IMPLink to PubMed article]
    protein amino acid phosphorylation [IDALink to PubMed article][IGILink to PubMed article]
    Molecular Function: ATP binding [ISSLink to PubMed article]
    protein binding [IPILink to PubMed article]
    eukaryotic translation initiation factor 2alpha kinase activity [IDALink to PubMed article]
    protein serine/threonine kinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRFFNAHKSA EDGNYSETTN AISLKNERQS RDLSVNKHGR MLLTALLENF CQLYDNNPAK  60
   61 SKRLFALICH TLQKIGILEE EYIEELAAVR SNYQDALHHL ILQAREAIRL DDAEERLLAL 120
  121 PDPTNVFEKF PQETALSKFS VDGLNVRQFR FRDLTLESWL QSRNSRYIED FEEYSLLGRG 180
  181 GFGSVYHVRN KIDGAEYAMK KINSTFQQMS YSKIFREIKC LAKMDHPNVI RYFSSWVEST 240
  241 TEATQMPIVM SKNSSRVLGT SSYCDVNGMD SIIFEPTESS ALTDDILFAE DPGTESIIST 300
  301 SRKSSYSSTT ESSNFENLES PRNLHDSNVS TFNNTTILDD DYSSSMHISK TGPTHSFIIY 360
  361 IQMQLCFDDL ESYLIRRNHF LSFPLCKEQI QLHTDLFRMI INGVMYVHEG VNLIHRDIKP 420
  421 SNIFLAKSLP EDRGSVPLIS YNDKNDLKEY ITPKIGDFGL VVENKKNTET ALSFLERNHL 480
  481 PNLQDETQHI GTATYAAPEL LDAMSSQHNK FTKKIDTFSL GMVLFELLHP FQTNMERATK 540
  541 LQDLRRGNLP EEFVEQHICE SSLILWMTAK DPTKRPSLLE VLNCGLLLPN QVSMPNISNI 600
  601 VSTNHLDVET QMKLIMDENQ RLREQIAVLR SRIQHLETR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..272] FFAS03 2.81 No description for 2acxA was found.
    2 View Details [273..639] PSI-BLAST 54.0 Crystal Structure of the Auto-Inhibited Kinase Domain of Calcium/Calmodulin Activated Kinase II


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle