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Protein Overview: his7

General Information:
Name(s) found: his7 / SPBC29A3.02c [Sanger Pombe]
Description(s) found:
Found 18 descriptions.
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  • phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase His7 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 417 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: histidine biosynthetic process [IGILink to PubMed article]
    Molecular Function: ATP binding [IEA]
    phosphoribosyl-ATP diphosphatase activity [ISSLink to PubMed article]
    phosphoribosyl-AMP cyclohydrolase activity [IGILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALLPFFDLT NFESDASEEL GWLKYVGRVQ TRVFPQHFKD NLEKVRKISE TIDVIVDTTA  60
   61 ELGPEACVNL LNAGALAILV NEEMLNELAD ISPNRLVLKT DTTDIGKIEK LSQVAGSIQW 120
  121 IGSAENYPPD FFERASKIIH KAVMPEGGGR TLYLEFPEQP SMEVLKSFSV HSVVPVLSSS 180
  181 FLTVKPAEEP KKLSLADLIL ISANTDREDG LFSTLVVNEL GIALGLVYSS KESVAESLKT 240
  241 GTGVYQSRKR GLWYKGASSG AVQHLIHIDV DCDEDCLRFV VYQTGKGFCH LDTLHCFGQA 300
  301 SGLCQLEKTL IDRKNNAPEG SYTARLFSDP KLLRAKIMEE AEELCDATTK ENVIWEMADL 360
  361 MYFAITRCVG SGVSLNDISR HLDLKHRKVT RRKGDAKVAW QEKLKDKGGV ANTSYTA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..199] deduced N/A No confident structure predictions are available.
    2 View Details [200..300] PSI-BLAST 44.522879 Crystal structure of Methanobacterium thermoautotrophicum phosphoribosyl-AMP cyclohydrolase HisI
    3 View Details [301..417] PSI-BLAST 22.0 Crystal structure of Phosphoribosyl-ATP pyrophosphohydrolase from Bacillus cereus. NESGC target BcR13.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • phosphoribosyl-AMP cyclohydrolase activity
    		•  4.07350794147607 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
    		•  1.83474502448328 bayes_pls_golite062009
  • catalytic activity
    		•  1.02941336036162 bayes_pls_golite062009
  • cyclohydrolase activity
    		•  0.335226474674779 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  0.0625072987078716 bayes_pls_golite062009
    3
    Term Confidence Notes
  • phosphoribosyl-ATP diphosphatase activity
    		•  3.62350723585237 bayes_pls_golite062009
  • phosphoribosyl-AMP cyclohydrolase activity
    		•  2.54150905806868 bayes_pls_golite062009
  • catalytic activity
    		•  0.634427093790328 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
    		•  0.324592130011053 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle