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Protein Overview: sre1

General Information:
Name(s) found: sre1 / SPBC19C2.09 [Sanger Pombe]
Description(s) found:
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  • pir||T39800 probable DNA-binding protein - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|74626009|sp|Q9UUD1.1|SREBP_SCHPO RecName: Full=Sterol regulatory element-binding protein 1; Contains: RecName: Full=Processed sterol regulatory element-binding protein 1 [NCBI NR]
  • gi|5689991|emb|CAB52036.1| sterol regulatory element binding protein, transcription factor Sre1 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19112486|ref|NP_595694.1| sterol regulatory element binding protein Sre1 [Schizosaccharomyces pombe] [NCBI NR]
  • sterol regulatory element binding protein Sre1 [Sanger Pombe]
  • Sterol regulatory element-binding protein 1 OS=Schizosaccharomyces pombe GN=sre1 PE=1 SV=1 [Swiss-Prot]
  • PUTATIVE TRANSCRIPTION FACTOR; SIMILAR TO S. CEREVISIAE YOR032C: Q9UUD1; [pompepVF.fasta]
  • Putative DNA-binding protein [pompep4896]
  • |||putative transcription factor [pompepnew.fasta]
  • SPBC19C2.09 protein [4896.FASTAC]
  • |sre1||membrane-tethered transcription factor (predicted) (PMID 11790253)|Schizosaccharomyces pombe|chr 2|||Manual [pombe041504.fasta]
  • putative DNA-binding protein [Schizosaccharomyces pombe]gi|5689991|emb|CAB52036.1| SPBC19C2.09 [Schizosaccharomyces pombe]gi|7492540|pir||T39800 probable DNA-binding protein - fission yeast (Schizosaccharomyces pombe) [nrdb_11152004_Chlamydomonas]
  • |sre1||membrane-tethered transcription factor |Schizosaccharomyces pombe|chr 2|||Manual [pompep2242005.fasta]
  • (Q9UUD1) Putative DNA-binding protein [pompep4896_normal_reversed]
  • |sre1||sterol regulatory element binding protein, transcription factor Sre1|Schizosaccharomyces pombe|chr 2|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • SPBC19C2.09 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPBC19C2.09 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • Sterol regulatory element-binding protein 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=sre1 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 900 amino acids

    Gene Ontology:
    Cellular Component: SREBP-SCAP complex [IDALink to PubMed article]
    nucleus [TASLink to PubMed article]
    integral to membrane [IEA]
    Biological Process: negative regulation of gene expression [IEPLink to PubMed article]
    oxygen and reactive oxygen species metabolic process [IMPLink to PubMed article]
    response to hypoxia [IMPLink to PubMed article]
    positive regulation of ergosterol biosynthetic process [IEPLink to PubMed article]
    positive regulation of heme biosynthetic process [IEPLink to PubMed article]
    positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway [IMPLink to PubMed article]
    positive regulation of lipid biosynthetic process [IEPLink to PubMed article][IMPLink to PubMed article]
    regulation of transcription, start site selection [IEPLink to PubMed article]
    Molecular Function: DNA binding [IDALink to PubMed article]
    transcription factor activity [IMPLink to PubMed article]
    specific RNA polymerase II transcription factor activity [RCALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQSSIPSVSV SVASPAMETP TKASPDSKSP NSVGAIPSSS PLASSTKAST STPFVENCSN  60
   61 LLCDLASIVE DSPPTLTNTS LSPHSFSLSD MESSMSNWLN PFAFDNTMNS APPLFTSTNM 120
  121 GSPNSLENST NPLLSNCGSP NSFQNETFTG PSLNEFDADD KIQRQMKILH SVDTIDPSTV 180
  181 QNYPSADMSN PEVKLKTEEI ITPMDTTCKP EPSAKKIKLS PSSEDSCSIP ETLPFSAPKS 240
  241 RGSLSPSETP DFVAGPGGKP KKTAHNMIEK RYRTNLNDRI CELRDAVPSL RAAAALRCGN 300
  301 SLDDEDLGGL TPARKLNKGT ILAKATEYIR HLEAKNKELQ KTNKQLSDRL AFYEDPSMAP 360
  361 PSNDTRAVNS VNVVSSSDYS VHQSSRPNLT QRAFTSPTLN TMGRTALNGM VGLGLFNYFG 420
  421 NDSSQSVYGL FALPPFLMSP FTGTVLFNML KIGVVLLGLF YLLHDNSLFK GFKGEKKSKV 480
  481 STRSSMSPSS ILFRKTVFEK YCLLDHSTST ISLFFGLLIF TLKSAYGYLT HRLSALYTSS 540
  541 ENWVYSEQQL AEVRNMEKLL DAQLMGGDAK VDRLRLLMVF ASSFSLPPSS HTCALQAMYC 600
  601 QLIFSNTSVP SAIVSKCVAF FWNAAKKQHS KSSVHAELRE LPECTANLIE NSHADDVFSP 660
  661 NMVERLWVLA KCTRDSAQMS DSIISSLSDV LVLSPLEVLA SWYAADLLDA LLMESLSRKV 720
  721 EISEIEEIIS LCPKNSSIIR HALLAKLVLF PENTADSLNE VLAAYKNTLD LCSQDKRKQS 780
  781 SVLKINLSKL FTLHSCLSLA LQRLGYGDVS KRMYQEIFVP DSDADITPLS FIISWTALNT 840
  841 FAPICTSPKE NDVVEKMAMY VRTAIGTLKI QDLKLSRKLI NSCIDIGSRL QEDLGYVSSA 900
  901

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..156] MSA 13.328997 View MSA. No confident structure predictions are available.
    2 View Details [157..255] deduced N/A No confident structure predictions are available.
    3 View Details [256..377] PSI-BLAST 21.154902 Myc prot-oncogene protein
    4 View Details [378..473] deduced N/A No confident structure predictions are available.
    5 View Details [474..678] deduced N/A No confident structure predictions are available.
    6 View Details [679..779] deduced N/A Confident ab initio structure predictions are available.
    7 View Details [780..900] deduced N/A Confident ab initio structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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