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Protein Overview: SPAC15E1.04

General Information:
Name(s) found: SPAC15E1.04 [Sanger Pombe]
Description(s) found:
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  • pir||T37719 thymidylate synthase-like DNA metabolism protein - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|74665572|sp|Q9UTI7.1|TYSY_SCHPO RecName: Full=Probable thymidylate synthase; Short=TSase; Short=TS [NCBI NR]
  • gi|5725409|emb|CAB52423.1| thymidylate synthase (predicted) [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19115217|ref|NP_594305.1| thymidylate synthase (predicted) [Schizosaccharomyces pombe 972h-] [NCBI NR]
  • thymidylate synthase [Sanger Pombe]
  • Probable thymidylate synthase OS=Schizosaccharomyces pombe GN=SPAC15E1.04 PE=2 SV=1 [Swiss-Prot]
  • THYMIDYLATE SYNTHASE-LIKE DNA METABOLISM PROTEIN: Q9UTI7; [pompepVF.fasta]
  • Thymidylate synthase-like DNA metabolism protein [pompep4896]
  • |||thymidylate synthase [pompepnew.fasta]
  • SPAC15E1.04 protein (EC 2.1.1.45) [4896.FASTAC]
  • |||thymidylate synthase (predicted)|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • thymidylate synthase-like DNA metabolism protein [Schizosaccharomyces pombe]gi|5725409|emb|CAB52423.1| SPAC15E1.04 [Schizosaccharomyces pombe]gi|7493481|pir||T37719 thymidylate synthase-like DNA metabolism protein - fission yeast (Schizosaccharomyces po [nrdb_11152004_Chlamydomonas]
  • |||thymidylate synthase |Schizosaccharomyces pombe|chr 1|||Manual [pompep2242005.fasta]
  • (Q9UTI7) Thymidylate synthase-like DNA metabolism protein [pompep4896_normal_reversed]
  • hypothetical protein SPAC15E1.04 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • SPAC15E1.04 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • Probable thymidylate synthase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC15E1.04 PE=3 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 625 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDALink to PubMed article]
    Biological Process: dTMP biosynthetic process [ISSLink to PubMed article]
    Molecular Function: thymidylate synthase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQPLHARFA TRAVKNPMIL EKERQLTDSK YHILVAATGS VAAIKLTLIV KSLLTYKGVD  60
   61 VQVVLTDPAR NFVEKEDLTA LGVNVYNNAD DWKNWDGLEC PITHIELRRW AHLLLIAPLS 120
  121 ANTMAKMANG LCDNLLTSLI RAWAPLKPIL LAPAMNTLMW TNPITQEHLS AISRIYKNSE 180
  181 FIMPIEKVLA CGDIGMGGMA EWRNIVGRVA DKLQLEQKSV LPNAVKNIDG QDDDSSEQTA 240
  241 AFEEYDDDDD DDVDDNEQSN SMIETSANAD ITPKASLLPS TTESSISKDH ETSQAPLGSE 300
  301 SVDTQASENV TTKPEPPVPF TSSEYRNTEE EQYLNLIRYI LENGQSRPDR TGTGTRSVFA 360
  361 PPQLRFSLRN NTLPLLTTKR VFLRGVLEEL LWFIHGDTNA NHLSEKGIHI WDGNGSREFL 420
  421 DSRGLTDRKV GDLGPIYGFQ WRHFGAQYVD CDTDYTNKGV DQLAQVISTL KLNPYDRRII 480
  481 LSAWNPLAIP EMALPPCHIF CQFYVSEPCK PGGKPQLSSM MYQRSADMGL GVPFNIASYS 540
  541 LLTHMIAHMC GYEAAEFVHV MGDCHIYNDH LEALQTQLER VPKAFPKLFF KRDAKDIGSI 600
  601 DSFSVDDFAV EGYNPYGPIK MKMSV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..217] PSI-BLAST 57.522879 crystal structure of human phosphopantothenoylcysteine decarboxylase
    2 View Details [218..327] PSI-BLAST 42.0 Phosphopantothenoylcysteine synthetase from E. coli
    3 View Details [328..625] PSI-BLAST 118.0 Thymidylate synthase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphopantothenoylcysteine decarboxylase activity
    		•  3.86093811191169 bayes_pls_golite062009
  • phosphopantothenate--cysteine ligase activity
    		•  2.64345867885176 bayes_pls_golite062009
  • binding
    		•  1.79334633421708 bayes_pls_golite062009
  • carboxy-lyase activity
    		•  1.79168084682693 bayes_pls_golite062009
  • catalytic activity
    		•  1.51672397362026 bayes_pls_golite062009
  • carbon-carbon lyase activity
    		•  1.03827559540394 bayes_pls_golite062009
  • protein binding
    		•  0.359358565373414 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • thymidylate synthase activity
    		•  6.6988475347328 bayes_pls_golite062009
  • 5,10-methylenetetrahydrofolate-dependent methyltransferase activity
    		•  6.29181090719132 bayes_pls_golite062009
  • binding
    		•  1.89072001556053 bayes_pls_golite062009
  • catalytic activity
    		•  1.73427871128495 bayes_pls_golite062009
  • transferase activity
    		•  1.72626940963556 bayes_pls_golite062009
  • methyltransferase activity
    		•  0.927096828883487 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  0.91282507161672 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.82

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle