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Protein Overview: set2

General Information:
Name(s) found: set2 / SPAC29B12.02c [Sanger Pombe]
Description(s) found:
Found 19 descriptions.
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  • histone lysine methyltransferase Set2 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 798 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    nuclear chromatin [ICLink to PubMed article]
    DNA-directed RNA polymerase II, core complex [IDALink to PubMed article]
    Biological Process: histone methylation [IDALink to PubMed article]
    RNA elongation from RNA polymerase II promoter [IGILink to PubMed article]
    regulation of transcription from RNA polymerase II promoter [ICLink to PubMed article]
    Molecular Function: histone methyltransferase activity (H3-K36 specific) [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQTASSLSVL TPLNEENVDR KSSWSKDTIA VQAVGSSPSS SSSHDFESKE DAEGMNKDES  60
   61 APSPSTSSPS SASSRSQSKY VRKEALPPQL FHHLDSAKDK ALTTFEEIQE CQYASANIGK 120
  121 PPENEAMICD CRPHWVDGVN VACGHGSNCI NRMTSIECTD EDNVCGPSCQ NQRFQRHEFA 180
  181 KVDVFLTEKK GFGLRADANL PKDTFVYEYI GEVIPEQKFR KRMRQYDSEG IKHFYFMMLQ 240
  241 KGEYIDATKR GSLARFCNHS CRPNCYVDKW MVGDKLRMGI FCKRDIIRGE ELTFDYNVDR 300
  301 YGAQAQPCYC GEPCCVGYIG GKTQTEAQSK LPENVREALG IEDEEDSWEN ITARRQRRKK 360
  361 GIDETSKIIE EVQPTPLTSE SATKVIGVLL QTKDDLLTRK LMERIFLTSD PSVCRSIIAL 420
  421 RGYNIFGLML KKFSIDIEFI LRSIKTMLSW PRLTRNKIQD SNIEPVVQEF CDHENEEVKD 480
  481 HAKTLLKEWE SLEIAYRIPR RKPGQVAPQS TNAEPSNNQS NPPLRDQEPQ RGDKGDIKSA 540
  541 INNSTEDLSK KHPALHSSRP SDSRSRSKFG NDYQSHSKHN LFRKNSFPKR RRLSNSDTPS 600
  601 ETTTPNNEQE QVSNQANKVD LNKIISAAME SVNQKNVLKA QKEEEERIAQ QKREEKRRLA 660
  661 YEESLKRHAK KLHEKKTKSS QDATIDHHLT SHSPESIAFK AVLAKFFANK TARYQEKLGK 720
  721 AEFKLRVKKM TEIILKKHIQ LVLSKKEKAL PDELSDSQQR KLRVWAFRYL DTVVSRSGTA 780
  781 TTTPTDSPSI GESPKKAA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..325] PSI-BLAST 49.0 SET domain of Clr4
    2 View Details [326..435] deduced N/A No confident structure predictions are available.
    3 View Details [436..505] FFAS03 1.0 Transcription elongation factor TFIIS N-domain
    4 View Details [506..682] deduced N/A No confident structure predictions are available.
    5 View Details [683..798] PSI-BLAST 16.69897 Structure and CTD binding of the Set2 SRI domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • histone methyltransferase activity
    		•  6.64131160914647 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  6.08778683840554 bayes_pls_golite062009
  • lysine N-methyltransferase activity
    		•  5.83932313719163 bayes_pls_golite062009
  • protein-lysine N-methyltransferase activity
    		•  5.83932313719163 bayes_pls_golite062009
  • histone-lysine N-methyltransferase activity
    		•  5.83932313719163 bayes_pls_golite062009
  • histone methyltransferase activity (H3-K9 specific)
    		•  5.55774492432055 bayes_pls_golite062009
  • transferase activity
    		•  4.61615951808413 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  3.98411678860954 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  2.69428385009711 bayes_pls_golite062009
  • methyltransferase activity
    		•  2.33114816345072 bayes_pls_golite062009
  • binding
    		•  2.2675356705139 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  2.25175257044903 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.20425750757954 bayes_pls_golite062009
  • chromatin binding
    		•  1.91712909042069 bayes_pls_golite062009
  • protein binding
    		•  0.938282161933492 bayes_pls_golite062009
  • catalytic activity
    		•  0.414641636618101 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle