YRC Public Data Repository - Protein Structure Prediction

Protein:	set2
Organism:	Schizosaccharomyces pombe
Length:	798 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for set2.

Description	E-value	Query Range	Subject Range
SET2_GIBZE - Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Gibberella zeae GN=SET2 PE=3 SV=1 SET2_GIBZE - Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Gibberella zeae (strain PH-1 / ATCC MYA...	617.0	[0..36]	[760..160]
SET2_NEUCR - Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Neurospora crassa GN=set-2 PE=3 SV=1 SET2_NEUCR - Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Neurospora crassa (strain ATCC 24698 / ...	597.0	[0..6]	[750..9]
gi\|39952037, gi\|... - gi\|39952037\|ref\|XP_363735.1\| hypothetical protein MGG_01661 [Magnaporthe grisea 70-15], gb\|EAA56010....	554.0	[0..25]	[757..28]
SET2_EMENI - Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Emericella nidulans GN=set2 PE=3 SV=1 SET2_EMENI - Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Emericella nidulans (strain FGSC A4 / A...	538.0	[0..48]	[757..94]
SET2_ASHGO - Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Ashbya gossypii GN=SET2 PE=3 SV=1 SET2_ASHGO - Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Ashbya gossypii (strain ATCC 10895 / CB...	536.0	[0..90]	[776..19]
SET2_USTMA - Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Ustilago maydis GN=SET2 PE=3 SV=1 SET2_USTMA - Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Ustilago maydis (strain 521 / FGSC 9021...	533.0	[0..2]	[793..83]
SET2_ASPFU - Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Neosartorya fumigata (strain ATCC MYA-4... SET2_ASPFU - Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Aspergillus fumigatus GN=set2 PE=3 SV=1	526.0	[0..13]	[761..49]
SET2 - Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of ...	523.0	[0..87]	[771..26]
SET2_CHAGB - Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Chaetomium globosum (strain ATCC 6205 /... SET2_CHAGB - Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Chaetomium globosum GN=SET2 PE=3 SV=1	518.0	[0..56]	[750..7]
SET2_ASPOR - Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Aspergillus oryzae GN=set2 PE=3 SV=1 SET2_ASPOR - Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Aspergillus oryzae (strain ATCC 42149 /...	498.0	[0..21]	[749..49]

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Predicted Domain #1

Region A:
Residues: [1-325]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQTASSLSVL TPLNEENVDR KSSWSKDTIA VQAVGSSPSS SSSHDFESKE DAEGMNKDES  60
   61 APSPSTSSPS SASSRSQSKY VRKEALPPQL FHHLDSAKDK ALTTFEEIQE CQYASANIGK 120
  121 PPENEAMICD CRPHWVDGVN VACGHGSNCI NRMTSIECTD EDNVCGPSCQ NQRFQRHEFA 180
  181 KVDVFLTEKK GFGLRADANL PKDTFVYEYI GEVIPEQKFR KRMRQYDSEG IKHFYFMMLQ 240
  241 KGEYIDATKR GSLARFCNHS CRPNCYVDKW MVGDKLRMGI FCKRDIIRGE ELTFDYNVDR 300
  301 YGAQAQPCYC GEPCCVGYIG GKTQT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	49.0
Match:	1mvhA
Description:	SET domain of Clr4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
histone methyltransferase activity	6.64131160914647	bayes_pls_golite062009
protein methyltransferase activity	6.08778683840554	bayes_pls_golite062009
lysine N-methyltransferase activity	5.83932313719163	bayes_pls_golite062009
protein-lysine N-methyltransferase activity	5.83932313719163	bayes_pls_golite062009
histone-lysine N-methyltransferase activity	5.83932313719163	bayes_pls_golite062009
histone methyltransferase activity (H3-K9 specific)	5.55774492432055	bayes_pls_golite062009
transferase activity	4.61615951808413	bayes_pls_golite062009
N-methyltransferase activity	3.98411678860954	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	2.69428385009711	bayes_pls_golite062009
methyltransferase activity	2.33114816345072	bayes_pls_golite062009
binding	2.2675356705139	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	2.25175257044903	bayes_pls_golite062009
nucleic acid binding	2.20425750757954	bayes_pls_golite062009
chromatin binding	1.91712909042069	bayes_pls_golite062009
protein binding	0.938282161933492	bayes_pls_golite062009
catalytic activity	0.414641636618101	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [326-435]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EAQSKLPENV REALGIEDEE DSWENITARR QRRKKGIDET SKIIEEVQPT PLTSESATKV  60
   61 IGVLLQTKDD LLTRKLMERI FLTSDPSVCR SIIALRGYNI FGLMLKKFSI

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [436-505]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DIEFILRSIK TMLSWPRLTR NKIQDSNIEP VVQEFCDHEN EEVKDHAKTL LKEWESLEIA  60
   61 YRIPRRKPGQ

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.0
Match:	1eo0A
Description:	Transcription elongation factor TFIIS N-domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [506-682]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VAPQSTNAEP SNNQSNPPLR DQEPQRGDKG DIKSAINNST EDLSKKHPAL HSSRPSDSRS  60
   61 RSKFGNDYQS HSKHNLFRKN SFPKRRRLSN SDTPSETTTP NNEQEQVSNQ ANKVDLNKII 120
  121 SAAMESVNQK NVLKAQKEEE ERIAQQKREE KRRLAYEESL KRHAKKLHEK KTKSSQD

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [683-798]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATIDHHLTSH SPESIAFKAV LAKFFANKTA RYQEKLGKAE FKLRVKKMTE IILKKHIQLV  60
   61 LSKKEKALPD ELSDSQQRKL RVWAFRYLDT VVSRSGTATT TPTDSPSIGE SPKKAA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	16.69897
Match:	2c5zA
Description:	Structure and CTD binding of the Set2 SRI domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: