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Protein Overview: est1

General Information:
Name(s) found: est1 / SPBC2D10.13 [Sanger Pombe]
Description(s) found:
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  • pir||T40116 hypothetical protein SPBC2D10.13 - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|74582562|sp|O74804.1|EST1_SCHPO RecName: Full=Telomere elongation protein est1; AltName: Full=Ever shorter telomeres protein 1 [NCBI NR]
  • gi|3687503|emb|CAA21171.1| telomerase regulator Est1 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19113024|ref|NP_596232.1| telomerase regulator Est1 [Schizosaccharomyces pombe] [NCBI NR]
  • telomerase regulator Est1 [Sanger Pombe]
  • Telomere elongation protein est1 OS=Schizosaccharomyces pombe GN=est1 PE=1 SV=1 [Swiss-Prot]
  • PROTEIN CONTAINING 1.5 TPR REPEATS; IMPLICATED IN TELOMERE LENGTH REGULATION; POSSIBLY INVOLVED IN TRANSCRIPTIONAL SILENCING; PUTATIVE PHOPSHODIESTERASE ACTIVITY; PUTATIVE 5' EXONUCLEASE/RIBONUCLEASE: O74804; [pompepVF.fasta]
  • PROTEIN CONTAINING 1.5 TPR REPEATS; IMPLICATED IN TELOMERE LENGTH REGULATION; IMPLICATED IN TRANSCRIPTIONAL SILENCING; PUTATIVE PHOPSHODIESTERASE ACTIVITY; PUTATIVE 5' EXONUCLEASE/RIBONUCLEASE: O74804; [pompepV13]
  • Hypothetical protein, putative coiled-coil regions [pompep4896]
  • |||TPR repeat protein [pompepnew.fasta]
  • Est1 protein (Spbc2d10.13 protein) [4896.FASTAC]
  • |est1||TPR repeat protein|Schizosaccharomyces pombe|chr 2|||Manual [pombe041504.fasta]
  • hypothetical protein; putative coiled-coil regions [Schizosaccharomyces pombe]gi|3687503|emb|CAA21171.1| SPBC2D10.13 [Schizosaccharomyces pombe]gi|7491569|pir||T40116 hypothetical protein SPBC2D10.13 - fission yeast (Schizosaccharomyces pombe) [nrdb_11152004_Chlamydomonas]
  • (O74804) Hypothetical protein, putative coiled-coil regions [pompep4896_normal_reversed]
  • |est1||telomerase regulator Est1|Schizosaccharomyces pombe|chr 2|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • SPBC2D10.13 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPBC2D10.13 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • Telomere elongation protein est1 (Ever shorter telomeres protein 1) [nr-271106-contam.fasta]
  • Telomere elongation protein est1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=est1 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 490 amino acids

    Gene Ontology:
    Cellular Component: chromosome, telomeric region [ICLink to PubMed article]
    nucleus [IDALink to PubMed article][ISSLink to PubMed article]
    spindle pole body [IDALink to PubMed article]
    protein complex [RCALink to PubMed article]
    nucleolus [ISSLink to PubMed article]
    telomerase holoenzyme complex [ISSLink to PubMed article]
    Biological Process: telomere maintenance via telomerase [IMPLink to PubMed article]
    Molecular Function: RNA binding [ISSLink to PubMed article]
    protein binding [IPILink to PubMed article]
    single-stranded telomeric DNA binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQQLSSNEI CEEQGKLVKA LCEAAQGGFK HDLYEKIIAI EIEVEKKLLN RLKSIQTNTF  60
   61 ERPDIIWSCC HYKIIQHFRS RFREIHPRHV VEKKKTKKVF FKFLKTCAIF YQTCISELIS 120
  121 KFQLDSYRPF FCKWTSSATV SSTISNDEMS SIPEASYSRN HMEALECVYN CFIYLGDMAR 180
  181 YSSTCLKKRG AYDRALGFYD LAHRTLPGNG MHRNQIAVVW ASDECIVESI YWFSSALCSE 240
  241 DPPKSALLNL LKQLIAFYRR CFAVHFEFVS PMMILLFIIS DCCIHSLKEI QPFKCPSIMV 300
  301 KDLENSLLQS NIRNVGYEKK NLYYISSAFS NLLHCRYFNC NDRLRSFYYR FSSWLFHQTL 360
  361 ACAKEVESER APTSYLTSCL PSIKVILARV LESSPAFGFI ERNELEQLSY HFRICEKFFK 420
  421 ESSENKMLNL FEDYNEFGLC KSFICLFKRL NEDIIGPKLN INPPDYTTHP FSESIKRFYQ 480
  481 ISKILNLLLS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..394] PSI-BLAST 95.69897 Crystal structure of the N-terminal domain of human SMG7
    2 View Details [395..490] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.52126334054344 bayes_pls_golite062009
  • protein binding
    		•  1.52807685989528 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.02070055347338 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.01193875360949 bayes_pls_golite062009
  • DNA binding
    		•  0.80346414607277 bayes_pls_golite062009
  • transcription factor activity
    		•  0.134824164012026 bayes_pls_golite062009
  • RNA binding
    		•  0.0901814112095951 bayes_pls_golite062009
  • signal sequence binding
    		•  0.0231142793406351 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.77

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle