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View Structure Prediction Details

Protein: est1
Organism: Schizosaccharomyces pombe
Length: 490 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for est1.

Description E-value Query
Range
Subject
Range
gi|109019248 - gi|109019248|ref|XP_001109289.1| PREDICTED: similar to SMG-7 homolog isoform 2 [Macaca mulatta]
374.0 [0..20] [387..297]
gi|76637907 - gi|76637907|ref|XP_877788.1| PREDICTED: similar to SMG-7 homolog isoform 2 isoform 6 [Bos taurus]
372.0 [0..20] [387..10]
SMG7 - Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
371.0 [0..20] [387..28]
gi|114568360 - gi|114568360|ref|XP_514048.2| PREDICTED: SMG-7 homolog [Pan troglodytes]
371.0 [0..20] [387..36]

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Predicted Domain #1
Region A:
Residues: [1-394]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQQLSSNEI CEEQGKLVKA LCEAAQGGFK HDLYEKIIAI EIEVEKKLLN RLKSIQTNTF  60
   61 ERPDIIWSCC HYKIIQHFRS RFREIHPRHV VEKKKTKKVF FKFLKTCAIF YQTCISELIS 120
  121 KFQLDSYRPF FCKWTSSATV SSTISNDEMS SIPEASYSRN HMEALECVYN CFIYLGDMAR 180
  181 YSSTCLKKRG AYDRALGFYD LAHRTLPGNG MHRNQIAVVW ASDECIVESI YWFSSALCSE 240
  241 DPPKSALLNL LKQLIAFYRR CFAVHFEFVS PMMILLFIIS DCCIHSLKEI QPFKCPSIMV 300
  301 KDLENSLLQS NIRNVGYEKK NLYYISSAFS NLLHCRYFNC NDRLRSFYYR FSSWLFHQTL 360
  361 ACAKEVESER APTSYLTSCL PSIKVILARV LESS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 95.69897
Match: 1ya0A
Description: Crystal structure of the N-terminal domain of human SMG7
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.52126334054344 bayes_pls_golite062009
protein binding 1.52807685989528 bayes_pls_golite062009
transcription regulator activity 1.02070055347338 bayes_pls_golite062009
nucleic acid binding 1.01193875360949 bayes_pls_golite062009
DNA binding 0.80346414607277 bayes_pls_golite062009
transcription factor activity 0.134824164012026 bayes_pls_golite062009
RNA binding 0.0901814112095951 bayes_pls_golite062009
signal sequence binding 0.0231142793406351 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [395-490]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PAFGFIERNE LEQLSYHFRI CEKFFKESSE NKMLNLFEDY NEFGLCKSFI CLFKRLNEDI  60
   61 IGPKLNINPP DYTTHPFSES IKRFYQISKI LNLLLS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle