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Protein Overview: chp2

General Information:
Name(s) found: chp2 / SPBC16C6.10 [Sanger Pombe]
Description(s) found:
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  • pir||T39561 probable transcription factor - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|74654628|sp|O42934.1|CHP2_SCHPO RecName: Full=Chromo domain-containing protein 2 [NCBI NR]
  • gi|2853102|emb|CAA16917.1| chromodomain protein 2 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19113600|ref|NP_596808.1| chromodomain protein 2 [Schizosaccharomyces pombe] [NCBI NR]
  • chromodomain protein 2 [Sanger Pombe]
  • Chromo domain-containing protein 2 OS=Schizosaccharomyces pombe GN=chp2 PE=2 SV=1 [Swiss-Prot]
  • PLEIOTROPHIC TRANSCRIPTIONAL SILENCING PROTEIN; NO APPARENT S. CEREVISIAE ORTHOLOG: O42934; [pompepVF.fasta]
  • PLEIOTROPHIC TRANSCRIPTIONAL SILENCING PROTEIN: O42934; [pompepV13]
  • Pleiotrophic transcriptional silencing protein [pompep4896]
  • |chp2||pleiotrophic transcriptional silencing protein [pompepnew.fasta]
  • Chp2 protein (Spbc16c6.10 protein) [4896.FASTAC]
  • |chp2||pleiotrophic transcriptional silencing protein|Schizosaccharomyces pombe|chr 2|||Manual [pombe041504.fasta]
  • pleiotrophic transcriptional silencing protein [Schizosaccharomyces pombe]gi|2853102|emb|CAA16917.1| SPBC16C6.10 [Schizosaccharomyces pombe]gi|7493045|pir||T39561 probable transcription factor - fission yeast (Schizosaccharomyces pombe) [nrdb_11152004_Chlamydomonas]
  • (O42934) Pleiotrophic transcriptional silencing protein [pompep4896_normal_reversed]
  • |chp2||chromodomain protein 2|Schizosaccharomyces pombe|chr 2|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • Chromo domain protein 2 [nr-271106-contam.fasta]
  • hypothetical protein SPBC16C6.10 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • SPBC16C6.10 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • Chromo domain-containing protein 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=chp2 PE=3 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 380 amino acids

    Gene Ontology:
    Cellular Component: mating-type region heterochromatin [TASLink to PubMed article]
    nucleus [IDALink to PubMed article]
    nuclear chromatin [ISSLink to PubMed article]
    nuclear telomeric heterochromatin [TASLink to PubMed article]
    spindle pole body [IDALink to PubMed article]
    centromeric heterochromatin [TASLink to PubMed article]
    Biological Process: chromatin remodeling [RCALink to PubMed article]
    chromatin silencing at centromere [IMPLink to PubMed article]
    chromatin silencing at rDNA [IMPLink to PubMed article]
    chromatin assembly or disassembly [IEA]
    chromatin silencing at silent mating-type cassette [IMPLink to PubMed article]
    chromatin silencing at telomere [IMPLink to PubMed article]
    Molecular Function: DNA binding [IEA]
    chromatin binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVKSADLDLM NSIISESDEN FSPPPFTVEE AENSINNKSS TASLESPQNG SWHPSLYGLS  60
   61 VPEKTHIQNS LDLYSHGNSG SQKTHNVSFS CEIRKVKSSK LSPISNMEDS EDKKEEDESS 120
  121 SYKNEFKSSS SASVSSNFEK TSGSDDHNSQ SPVPLNEGFE YIASSGSEDK NSDEEFAVEM 180
  181 ILDSRMKKDG SGFQYYLKWE GYDDPSDNTW NDEEDCAGCL ELIDAYWESR GGKPDLSSLI 240
  241 RLTRSRARSS NEASYVEKDE SSNSDDSISY KRRRSRNAAN RITDYVDSDL SESSMKEKQS 300
  301 KIEKYMKSDK SSKNFKPPFQ KKSWEDLVDC VKTVQQLDNG KLIAKIKWKN GYVSTHDNII 360
  361 IHQKCPLKII EYYEAHIKFT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..171] MSA 3.126997 View MSA. No confident structure predictions are available.
    2 View Details [172..313] PSI-BLAST 6.522879 Tandem chromodomains of human CHD1 complexed with Histone H3 Tail containing trimethyllysine 4 and dimethylarginine 2
    3 View Details [314..380] PSI-BLAST 11.045757 Heterochromatin protein 1, HP1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription repressor activity
    		•  4.08500855631983 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.64390820819794 bayes_pls_golite062009
  • chromatin binding
    		•  3.1924157640698 bayes_pls_golite062009
  • methylated histone residue binding
    		•  3.18095357415772 bayes_pls_golite062009
  • binding
    		•  3.06758476214113 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.19167058827256 bayes_pls_golite062009
  • DNA binding
    		•  2.05514577638135 bayes_pls_golite062009
  • protein binding
    		•  1.61683263008775 bayes_pls_golite062009
  • histone binding
    		•  1.37812404837999 bayes_pls_golite062009
  • general transcriptional repressor activity
    		•  0.75184432495983 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.294457188332415 bayes_pls_golite062009
  • satellite DNA binding
    		•  0.158790063943709 bayes_pls_golite062009
  • catalytic activity
    		•  0.14067200158938 bayes_pls_golite062009
  • transcription activator activity
    		•  0.136090220479238 bayes_pls_golite062009
    3
    Term Confidence Notes
  • transcription repressor activity
    		•  4.08500855631983 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.64390820819794 bayes_pls_golite062009
  • chromatin binding
    		•  3.1924157640698 bayes_pls_golite062009
  • methylated histone residue binding
    		•  3.18095357415772 bayes_pls_golite062009
  • binding
    		•  3.06758476214113 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.19167058827256 bayes_pls_golite062009
  • DNA binding
    		•  2.05514577638135 bayes_pls_golite062009
  • protein binding
    		•  1.61683263008775 bayes_pls_golite062009
  • histone binding
    		•  1.37812404837999 bayes_pls_golite062009
  • general transcriptional repressor activity
    		•  0.75184432495983 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.294457188332415 bayes_pls_golite062009
  • satellite DNA binding
    		•  0.158790063943709 bayes_pls_golite062009
  • catalytic activity
    		•  0.14067200158938 bayes_pls_golite062009
  • transcription activator activity
    		•  0.136090220479238 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle