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Protein Overview: pus2

General Information:
Name(s) found: pus2 / SPBC887.11 [Sanger Pombe]
Description(s) found:
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  • pir||T40736 probable pseudouridylate synthase - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|74676179|sp|O94295.1|PUS2_SCHPO RecName: Full=tRNA pseudouridine synthase 2; AltName: Full=tRNA-uridine isomerase 2; AltName: Full=tRNA pseudouridylate synthase 2 [NCBI NR]
  • gi|3850107|emb|CAA21896.1| tRNA pseudouridine synthase Pus2 (predicted) [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19113277|ref|NP_596485.1| tRNA pseudouridylate synthase Pus2 (predicted) [Schizosaccharomyces pombe] [NCBI NR]
  • tRNA pseudouridylate synthase Pus2 [Sanger Pombe]
  • tRNA pseudouridine synthase 2 OS=Schizosaccharomyces pombe GN=pus2 PE=2 SV=1 [Swiss-Prot]
  • PUTATIVE PSEUDOURIDYLATE SYNTHASE: O94295; [pompepVF.fasta]
  • Putative pseudouridylate synthase [pompep4896]
  • |||putative tRNA pseudouridylate synthase [pompepnew.fasta]
  • SPBC887.11 protein [4896.FASTAC]
  • |||tRNA pseudouridylate synthase (predicted)|Schizosaccharomyces pombe|chr 2|||Manual [pombe041504.fasta]
  • putative pseudouridylate synthase [Schizosaccharomyces pombe]gi|3850107|emb|CAA21896.1| SPBC887.11 [Schizosaccharomyces pombe]gi|7492879|pir||T40736 probable pseudouridylate synthase - fission yeast (Schizosaccharomyces pombe) [nrdb_11152004_Chlamydomonas]
  • |||tRNA pseudouridylate synthase |Schizosaccharomyces pombe|chr 2|||Manual [pompep2242005.fasta]
  • (O94295) Putative pseudouridylate synthase [pompep4896_normal_reversed]
  • |pus2||tRNA pseudouridine synthase Pus2 |Schizosaccharomyces pombe|chr 2|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • SPBC887.11 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • tRNA pseudouridine synthase 2 (tRNA-uridine isomerase 2) (tRNA pseudouridylate synthase 2) [nr-271106-contam.fasta]
  • hypothetical protein SPBC887.11 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • tRNA pseudouridylate synthase Pus2 (predicted) [Schizosaccharomyces pombe] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • tRNA pseudouridine synthase 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pus2 PE=3 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 451 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][ISSLink to PubMed article]
    Biological Process: tRNA pseudouridine synthesis [ISSLink to PubMed article]
    Molecular Function: zinc ion binding [IEA]
    RNA binding [IEA]
    pseudouridine synthase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSISKRKNQ QEHIPAEDLE TPKLPKREKI EGTKESNKVR IIILLGYSGY GYHGIQINNP  60
   61 LKTIEGDVVA VLKKLGYLKT NNIDAEHLCI ARAARTDKGV HTLRNLISLN LFVDKPLDIS 120
  121 LLKTELNEAL CSQIRVWSVF PAPKYFNPRI SCESRTYEYL IPSFALLPPK PSCPLFKKMQ 180
  181 KNLSRKLDNE LERNLVYSMN DLISFWNTVK LKQKEIQEMF DTNKDAFTNP FKGMFYEKPI 240
  241 PAGIVIPPQA KLKKALKQAE YYCYMNYRIK EDRLKVLQQL LKKYEGRHNF HNFTVTDDST 300
  301 SPSNYRFIES VTCGTPFVYE NWEWIPVTIK GNSFMLNQIR KMMAHVLMII RSCAPTGLID 360
  361 KAFDPNITMN ISKSPGHVLL LKDIKFSSYN DSVTDGLEKI QFDCFEEDIL SLKIKTIYPD 420
  421 IIKLEQKEKL FFSFLSYIDQ HTGHQFDYLF G

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..264] PSI-BLAST 62.39794 No description for 2nqpA was found.
    2 View Details [265..451] FFAS03 5.12 No description for 2nqpA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • pseudouridine synthase activity
    		•  5.19957135839682 bayes_pls_golite062009
  • intramolecular transferase activity
    		•  3.78688422405974 bayes_pls_golite062009
  • isomerase activity
    		•  2.91720316078381 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.31595692797262 bayes_pls_golite062009
  • catalytic activity
    		•  2.02180970970004 bayes_pls_golite062009
  • binding
    		•  1.84674955201903 bayes_pls_golite062009
  • DNA binding
    		•  1.71136719569439 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.59449441921256 bayes_pls_golite062009
  • RNA binding
    		•  0.706879359688019 bayes_pls_golite062009
    2
    Term Confidence Notes
  • pseudouridine synthase activity
    		•  4.5073655253958 bayes_pls_golite062009
  • intramolecular transferase activity
    		•  3.19253766449143 bayes_pls_golite062009
  • isomerase activity
    		•  2.45191348951047 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.32498104079149 bayes_pls_golite062009
  • binding
    		•  1.91512224392568 bayes_pls_golite062009
  • catalytic activity
    		•  1.86133205308688 bayes_pls_golite062009
  • DNA binding
    		•  1.72027738367097 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.61677004803653 bayes_pls_golite062009
  • RNA binding
    		•  0.673531276607007 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle