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Protein Overview: mlh1

General Information:
Name(s) found: mlh1 / SPBC1703.04 [Sanger Pombe]
Description(s) found:
Found 20 descriptions.
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  • MutL family protein Mlh1 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 684 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    spindle pole body [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: mismatch repair [TASLink to PubMed article]
    Molecular Function: DNA binding [ISSLink to PubMed article]
    ATP binding [IEA]
    mismatched DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDVNSRAKIR PLDQLVINKI AAGEIIERPE NAIKELIENS LDAGSTSIDV LLKDGGLKLL  60
   61 QITDNGSGIQ YDDLPYLCQR FSTSKIDNFN DLQHLQTFGF RGEALASISH VAKVTVVTKL 120
  121 SSDIHAWKAF YVDGALAPIS PGMSPAPQPC AGKQGTVITA EDLFYNVRSR KSALKNGSEE 180
  181 FRRIMILVQK YAIHNDQVSF NCKKVGDTVA SLSLSSRLSK ADKIRHIYGP RVASHLRDFS 240
  241 LGEGQSSIVG FSANGFISNA DFQDKKSNLI LFINNRLVES VELRHALEET YAKYLHKGAS 300
  301 YFVYLSLNMS PEQLDVNVHP SKRIVHFLYD QEIATSICDK LGEILERTDT ERSYPLQAMI 360
  361 PSISNTKNAE SSSQKAVRTY ENYLVRTDPR ERSIKSMLSD NFLQRSSNNY DNEIIEKVDS 420
  421 ANSNKNATND IKDLQTEEIV EEGNSIDLES IKSLQKQVIN SMHVLATNIL TEHKYVGLVC 480
  481 PTRRIAAVQH NIGLYVVDYG KLSYHLFYQI CLTEFGNYGE FVLETPLSIS DLFEIVNGDE 540
  541 DKSESEKFTR LLVSRRDMLK DYFSISVTSG GLLTAVPMLS PKYHPPFEQL PLLISSLTPK 600
  601 FFDWLDEKSC LNGIMKAIAK FYVPLPLSYE ESDVKSIRSL ESCLEDYLFP EFRRRVICPK 660
  661 KVFEEKCIYQ ITSLPRLYNV FERC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..407] PSI-BLAST 67.154902 DNA mismatch repair protein MutL
    2 View Details [408..470] deduced N/A No confident structure predictions are available.
    3 View Details [471..684] PSI-BLAST 15.0 Crystal structure of the MutL C-terminal domain


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle