YRC Public Data Repository - Protein Structure Prediction

Protein:	mlh1
Organism:	Schizosaccharomyces pombe
Length:	684 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mlh1.

Description	E-value	Query Range	Subject Range
gi\|73989704 - gi\|73989704\|ref\|XP_534219.2\| PREDICTED: similar to MutL protein homolog 1 isoform 1 [Canis familiari...	450.0	[0..6]	[684..5]
gi\|114585960, gi... - gi\|114585960\|ref\|XP_001170433.1\| PREDICTED: MutL protein homolog 1 isoform 8 [Pan troglodytes], gi\|1...	436.0	[0..6]	[684..5]
gi\|48476966 - gi\|48476966\|gb\|AAT44531.1\| hypothetical rhabdomyosarcoma antigen MU-RMS-40.5 [Homo sapiens]	435.0	[0..6]	[684..4]
gi\|32417074, gi\|... - gi\|32417074\|ref\|XP_329015.1\| hypothetical protein [Neurospora crassa], gi\|28924130\|gb\|EAA33286.1\| hy... gi\|85108177 - gi\|85108177\|ref\|XP_962522.1\| hypothetical protein NCU08309 [Neurospora crassa OR74A]	434.0	[0..4]	[684..26]
gi\|46136425, gi\|... - gi\|46136425\|ref\|XP_389904.1\| hypothetical protein FG09728.1 [Gibberella zeae PH-1], gi\|42554934\|gb\|E...	431.0	[0..7]	[684..41]
gi\|41054934, gi\|... - gi\|41054934\|ref\|NP_956953.1\| mutL homolog 1, colon cancer, nonpolyposis type 2 [Danio rerio], gi\|347...	423.0	[0..6]	[684..2]
gi\|67515689, gi\|... - gi\|67515689\|ref\|XP_657730.1\| hypothetical protein AN0126.2 [Aspergillus nidulans FGSC A4], ref\|XP_40...	422.0	[0..7]	[684..29]

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Predicted Domain #1

Region A:
Residues: [1-407]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDVNSRAKIR PLDQLVINKI AAGEIIERPE NAIKELIENS LDAGSTSIDV LLKDGGLKLL  60
   61 QITDNGSGIQ YDDLPYLCQR FSTSKIDNFN DLQHLQTFGF RGEALASISH VAKVTVVTKL 120
  121 SSDIHAWKAF YVDGALAPIS PGMSPAPQPC AGKQGTVITA EDLFYNVRSR KSALKNGSEE 180
  181 FRRIMILVQK YAIHNDQVSF NCKKVGDTVA SLSLSSRLSK ADKIRHIYGP RVASHLRDFS 240
  241 LGEGQSSIVG FSANGFISNA DFQDKKSNLI LFINNRLVES VELRHALEET YAKYLHKGAS 300
  301 YFVYLSLNMS PEQLDVNVHP SKRIVHFLYD QEIATSICDK LGEILERTDT ERSYPLQAMI 360
  361 PSISNTKNAE SSSQKAVRTY ENYLVRTDPR ERSIKSMLSD NFLQRSS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	67.154902
Match:	1bknA
Description:	DNA mismatch repair protein MutL
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [408-470]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNYDNEIIEK VDSANSNKNA TNDIKDLQTE EIVEEGNSID LESIKSLQKQ VINSMHVLAT  60
   61 NIL

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [471-684]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TEHKYVGLVC PTRRIAAVQH NIGLYVVDYG KLSYHLFYQI CLTEFGNYGE FVLETPLSIS  60
   61 DLFEIVNGDE DKSESEKFTR LLVSRRDMLK DYFSISVTSG GLLTAVPMLS PKYHPPFEQL 120
  121 PLLISSLTPK FFDWLDEKSC LNGIMKAIAK FYVPLPLSYE ESDVKSIRSL ESCLEDYLFP 180
  181 EFRRRVICPK KVFEEKCIYQ ITSLPRLYNV FERC

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	15.0
Match:	1x9zA
Description:	Crystal structure of the MutL C-terminal domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits