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Protein Overview: SPAC139.05

General Information:
Name(s) found: SPAC139.05 [Sanger Pombe]
Description(s) found:
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  • pir||T37606 probable succinate semialdehyde dehydrogenase - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|74638897|sp|Q9UTM8.1|SSDH2_SCHPO RecName: Full=Putative succinate-semialdehyde dehydrogenase C139.05 [NADP+]; Short=SSDH [NCBI NR]
  • gi|6137068|emb|CAB59619.1| succinate-semialdehyde dehydrogenase (predicted) [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19114084|ref|NP_593172.1| succinate-semialdehyde dehydrogenase (predicted) [Schizosaccharomyces pombe] [NCBI NR]
  • succinate-semialdehyde dehydrogenase [Sanger Pombe]
  • Putative succinate-semialdehyde dehydrogenase C139.05 [NADP+] OS=Schizosaccharomyces pombe GN=SPAC139.05 PE=2 SV=1 [Swiss-Prot]
  • PUTATIVE SUCCINATE SEMIALDEHYDE DEHYDROGENASE: Q9UTM8; [pompepVF.fasta]
  • PROBABLE SUCCINATE SEMIALDEHYDE DEHYDROGENASE: Q9UTM8; [pompepV13]
  • Probable succinate semialdehyde dehydrogenase [pompep4896]
  • |||putative succinate semialdehyde dehydrogenase [pompepnew.fasta]
  • SPAC139.05 protein (EC 1.2.1.16) [4896.FASTAC]
  • |||succinate semialdehyde dehydrogenase (predicted)|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • probable succinate semialdehyde dehydrogenase [Schizosaccharomyces pombe]gi|6137068|emb|CAB59619.1| SPAC139.05 [Schizosaccharomyces pombe]gi|7493008|pir||T37606 probable succinate semialdehyde dehydrogenase - fission yeast (Schizosaccharomyces pombe) [nrdb_11152004_Chlamydomonas]
  • |||succinate semialdehyde dehydrogenase |Schizosaccharomyces pombe|chr 1|||Manual [pompep2242005.fasta]
  • (Q9UTM8) Probable succinate semialdehyde dehydrogenase [pompep4896_normal_reversed]
  • |||succinate-semialdehyde dehydrogenase |Schizosaccharomyces pombe|chr 1|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • SPAC139.05 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPAC139.05 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • Putative succinate-semialdehyde dehydrogenase C139.05 [NADP(+)] OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC139.05 PE=3 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 493 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [ISSLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: glutamate catabolic process [ISSLink to PubMed article]
    cellular response to stress [IEPLink to PubMed article]
    Molecular Function: succinate-semialdehyde dehydrogenase [NAD(P)+] activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAPQFKRPEL FGFDKSHAQS FVQGKWISSP NNKTFEVDNP ATGEIIGKVA DVSVEETKKA  60
   61 ISAANEAFKT YKNFTHVQRS QLLERWAELI MENKDDLVKM LTLENGKPLS QAEMEVTTCS 120
  121 GYLKWYAAEA VRTFGDVAPS SLQSQNFLIS IKQPVGVSAL ITPWNFPAAM IARKGGAALA 180
  181 AGCTAIFLPA FRTPYVCLGL VRLAQEAGFP DGVLNVITSS DASAHGKELT TNPIVRKVSF 240
  241 TGSTNVGKIL MGQSASTIKK VSMELGGNAP FIVFPDFPID QAVESFCTIK FNSCGQVCVC 300
  301 PNRVYVHKNV YDEFVSKLTE KVKTIKVGDG FDSSSAVGPL ISQDGCKKVS KHIEDAVSKG 360
  361 AKITVGGKEI SSSKGYFFEP TVLSGVTQDM LVASEETFGP LASVFKFDDT EEVIEWANDS 420
  421 DVGLAGYVFT NNLSTMIHVA KELEVGLVGA NIEMVDEPFI SFGGIKQSGF GKEAGRLGVQ 480
  481 EFMVVKEINL KTL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run spc19 No Comments Liu X, et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..493] PSI-BLAST 167.0 Aldehyde reductase (dehydrogenase), ALDH

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  5.09598561374689 bayes_pls_golite062009
  • oxidoreductase activity
    		•  4.47226217021998 bayes_pls_golite062009
  • 1-pyrroline-5-carboxylate dehydrogenase activity
    		•  4.35175408702761 bayes_pls_golite062009
  • malonate-semialdehyde dehydrogenase (acetylating) activity
    		•  4.2273960318884 bayes_pls_golite062009
  • methylmalonate-semialdehyde dehydrogenase (acylating) activity
    		•  3.87605237828483 bayes_pls_golite062009
  • succinate-semialdehyde dehydrogenase [NAD(P)+] activity
    		•  3.64672165191647 bayes_pls_golite062009
  • 3-chloroallyl aldehyde dehydrogenase activity
    		•  3.37049090049734 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
    		•  3.2867555127991 bayes_pls_golite062009
  • benzaldehyde dehydrogenase activity
    		•  2.99564252244797 bayes_pls_golite062009
  • aldehyde dehydrogenase (NAD) activity
    		•  2.81851373615334 bayes_pls_golite062009
  • catalytic activity
    		•  2.80804701752928 bayes_pls_golite062009
  • glutamate-5-semialdehyde dehydrogenase activity
    		•  2.78416888468693 bayes_pls_golite062009
  • succinate-semialdehyde dehydrogenase activity
    		•  2.71501590413507 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors
    		•  2.70230501280821 bayes_pls_golite062009
  • aldehyde dehydrogenase [NAD(P)+] activity
    		•  2.43250909158896 bayes_pls_golite062009
  • aminobutyraldehyde dehydrogenase activity
    		•  2.35958138496479 bayes_pls_golite062009
  • acyl-CoA binding
    		•  2.26220696569489 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
    		•  1.6559690223037 bayes_pls_golite062009
  • retinal dehydrogenase activity
    		•  1.42867174920845 bayes_pls_golite062009
  • electron carrier activity
    		•  1.33390667257376 bayes_pls_golite062009
  • binding
    		•  1.06673666884196 bayes_pls_golite062009
  • retinoid binding
    		•  0.983782635681687 bayes_pls_golite062009
  • isoprenoid binding
    		•  0.900374761028287 bayes_pls_golite062009
  • protein binding
    		•  0.894945263794726 bayes_pls_golite062009
  • hydrolase activity
    		•  0.799513645745266 bayes_pls_golite062009
  • histidinol dehydrogenase activity
    		•  0.258030369394064 bayes_pls_golite062009
  • benzaldehyde dehydrogenase (NAD+) activity
    		•  0.23487570676521 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.77

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle