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Protein Overview: SPBC1711.04

General Information:
Name(s) found: SPBC1711.04 [Sanger Pombe]
Description(s) found:
Found 16 descriptions.
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  • methylenetetrahydrofolate reductase [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 320 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytosol [IDALink to PubMed article][ISSLink to PubMed article]
    Biological Process: folic acid biosynthetic process [ISS]
    purine base biosynthetic process [ISS]
    one-carbon metabolic process [IEA]
    Molecular Function: methylenetetrahydrofolate dehydrogenase (NAD+) activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNTNKSEPN HSCKVVYASR VAETFVEQLK QHVNLFEFAP KLVGFLSNSD PAARMYADWT  60
   61 NKTCTEIGFQ YELREVPKDD LEDAIVEANN DPSVNGIMIY FPVFNDGQDQ YLQQVVSPDK 120
  121 DVEGLCHKYV MNMYHNIRHL DPEKTKKSIL PCTPLAIVKI LEYLGVYNKI INYGNRLYGK 180
  181 TITIVNRSEI VGRPLAALLA NDGAKVYSVD IHNVQCFTRG AGIRSKKHDV ADTNFKLEDV 240
  241 APISDVIICG VPSANYKFPS NLVRDGAVCI CFSSEKNFDA ASLKEHAGIY VPSIGKVTIA 300
  301 MLLRNLIRLT SYQLNKPVDI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..320] PSI-BLAST 74.154902 Methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Tetrahydrofolate dehydrogenase/cyclohydrolase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity
    		•  3.54983447672782 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  2.66605122152932 bayes_pls_golite062009
  • malate dehydrogenase activity
    		•  2.43636049081724 bayes_pls_golite062009
  • catalytic activity
    		•  2.0643953589843 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.95832530533882 bayes_pls_golite062009
  • methenyltetrahydrofolate cyclohydrolase activity
    		•  1.95551536198286 bayes_pls_golite062009
  • DNA binding
    		•  1.70073234884672 bayes_pls_golite062009
  • binding
    		•  1.57522146187634 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.54527841865655 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.47211855405194 bayes_pls_golite062009
  • malic enzyme activity
    		•  1.39067036188188 bayes_pls_golite062009
  • transcription factor activity
    		•  0.9895904275677 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
    		•  0.66392365734856 bayes_pls_golite062009
  • cyclohydrolase activity
    		•  0.129148522173579 bayes_pls_golite062009
  • ligase activity
    		•  0.0191278372003161 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle