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Protein Overview: pcm1

General Information:
Name(s) found: pcm1 / SPCC330.10 [Sanger Pombe]
Description(s) found:
Found 15 descriptions.
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  • mRNA capping methyltransferase [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 389 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][IGILink to PubMed article]
    cell division site [IDALink to PubMed article]
    DNA-directed RNA polymerase II, holoenzyme [ISSLink to PubMed article]
    P-TEFb-cap methyltransferase complex [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: RNA methylation [ICLink to PubMed article]
    mRNA capping [IGILink to PubMed article]
    Molecular Function: RNA binding [IEA]
    mRNA (guanine-N7-)-methyltransferase activity [IGILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSHHMMERS LTFERNYSHL FIIIFIIRDM SSSNSRVHEE QPPTENRRYA RPTAQMNRVI  60
   61 EQQPRRRDYF QNNDNSGRRG YNRHENNGNA QDVVRSHYNA RPDLGYKKRQ FSPIIQLKRF 120
  121 NNWIKSVLIQ KFAPHASDYP ILVLDMGCGK GGDLIKWDKA GIDGYIGIDI AEVSVNQAKK 180
  181 RYREMHASFD ALFYAGDCFS SSINELLPPD QRKFDVVSLQ FCMHYAFESE EKVRVLLGNV 240
  241 SKCLPRGGVM IGTIPNSDVI VKHIKMLKPG EKEWGNDIYK VRFPESPPRS FRPPYGIQYY 300
  301 FYLEDAVTDV PEYVVPFEAF RAVAEGYNLE LIWVKPFLDI LNEEKNSETY GPLMDRMKVV 360
  361 DNEGHRGIGG QEKEAAGFYL AFAFEKRGI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..87] PSI-BLAST 12.69897 Crystal structure of aclacinomycin-10-hydroxylase (RdmB) in complex with S-adensyl-L-methionine (SAM)
    2 View Details [88..389] PSI-BLAST 36.0 Structure and mechanism of mRNA cap (guanine N-7) methyltransferase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • mRNA methyltransferase activity
    		•  4.23788594273427 bayes_pls_golite062009
  • mRNA (guanine-N7-)-methyltransferase activity
    		•  4.23788594273427 bayes_pls_golite062009
  • methyltransferase activity
    		•  4.15445027778357 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  4.07806017452628 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  4.07153733729662 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  3.92746815303714 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  3.39429041855776 bayes_pls_golite062009
  • RNA methyltransferase activity
    		•  3.07428840534971 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  2.99461585647365 bayes_pls_golite062009
  • transferase activity
    		•  2.926540904444 bayes_pls_golite062009
  • arginine N-methyltransferase activity
    		•  2.41876112831625 bayes_pls_golite062009
  • protein-arginine N-methyltransferase activity
    		•  2.41876112831625 bayes_pls_golite062009
  • DNA-methyltransferase activity
    		•  2.39581687084457 bayes_pls_golite062009
  • rRNA methyltransferase activity
    		•  2.29640050660273 bayes_pls_golite062009
  • histone-arginine N-methyltransferase activity
    		•  2.04296107639729 bayes_pls_golite062009
  • tRNA methyltransferase activity
    		•  1.76571145896453 bayes_pls_golite062009
  • protein-arginine omega-N monomethyltransferase activity
    		•  1.66871163498737 bayes_pls_golite062009
  • catalytic activity
    		•  1.25333584501255 bayes_pls_golite062009
  • rRNA (uridine) methyltransferase activity
    		•  1.22029787395194 bayes_pls_golite062009
  • histone methyltransferase activity (H4-R3 specific)
    		•  1.1103522853299 bayes_pls_golite062009
  • RNA binding
    		•  1.10729923226801 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.914549843668268 bayes_pls_golite062009
  • protein-arginine omega-N asymmetric methyltransferase activity
    		•  0.89325812193225 bayes_pls_golite062009
  • DNA binding
    		•  0.86027591375666 bayes_pls_golite062009
  • site-specific DNA-methyltransferase (adenine-specific) activity
    		•  0.703178429468566 bayes_pls_golite062009
  • tRNA (cytosine)-methyltransferase activity
    		•  0.672282175551951 bayes_pls_golite062009
  • tRNA (cytosine-5-)-methyltransferase activity
    		•  0.672282175551951 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.616949327277483 bayes_pls_golite062009
  • rRNA (adenine) methyltransferase activity
    		•  0.533090627724779 bayes_pls_golite062009
  • rRNA (adenine-N6,N6-)-dimethyltransferase activity
    		•  0.455449410561251 bayes_pls_golite062009
  • binding
    		•  0.383237930789959 bayes_pls_golite062009
  • protein-arginine omega-N symmetric methyltransferase activity
    		•  0.364369105571521 bayes_pls_golite062009
  • tRNA (adenine)-methyltransferase activity
    		•  0.31838575620236 bayes_pls_golite062009
  • tRNA (adenine-N1-)-methyltransferase activity
    		•  0.31838575620236 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.68

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle