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Protein Overview: mrc1

General Information:
Name(s) found: mrc1 / SPAC694.06c [Sanger Pombe]
Description(s) found:
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  • gi|6901201|emb|CAB71844.1| mediator of replication checkpoint 1 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|46396534|sp|Q9P7T4.1|MRC1_SCHPO RecName: Full=Mediator of replication checkpoint protein 1; AltName: Full=DNA replication checkpoint mediator mrc1 [NCBI NR]
  • gi|19115398|ref|NP_594486.1| mediator of replication checkpoint 1 [Schizosaccharomyces pombe] [NCBI NR]
  • pir||T50251 hypothetical coiled-coil protein [imported] - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • mediator of replication checkpoint 1 [Sanger Pombe]
  • Mediator of replication checkpoint protein 1 OS=Schizosaccharomyces pombe GN=mrc1 PE=1 SV=1 [Swiss-Prot]
  • PREDICTED COILED-COIL PROTEIN; VERY LOW SIMILAR TO S. CEREVISIAE MRC1 INVOLVED IN DNA REPLICATION CHECKPOINT AND INVOLVED IN CHROMATIN SILENCING: Q9P7T4; [pompepVF.fasta]
  • HYPOTHETICAL COILED-COIL PROTEIN WITH VERY LOW SIMILARITY TO S. CEREVISIAE MRC1 WHICH IS INVOLVED IN DNA REPLICATION CHECKPOINT AND INVOLVED IN CHROMATIN SILENCING: Q9P7T4; [pompepV13]
  • Hypothetical coiled-coil protein [pompep4896]
  • |mrc1||involved in DNA replication checkpoint (PMID 11715016) [pompepnew.fasta]
  • Mediator of replication checkpoint protein 1 (DNA replication checkpoint mediator mrc1) [4896.FASTAC]
  • |mrc1||involved in DNA replication checkpoint (PMID 11715016)|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • hypothetical coiled-coil protein [Schizosaccharomyces pombe]gi|6901201|emb|CAB71844.1| SPAC694.06c [Schizosaccharomyces pombe]gi|46396534|sp|Q9P7T4|MRC1_SCHPO Mediator of replication checkpoint protein 1 (DNA replication checkpoint mediator mrc1)gi|113 [nrdb_11152004_Chlamydomonas]
  • |mrc1||mediator of replication checkpoint 1 |Schizosaccharomyces pombe|chr 1|||Manual [pompep2242005.fasta]
  • (Q9P7T4) Hypothetical coiled-coil protein [pompep4896_normal_reversed]
  • |mrc1||mediator of replication checkpoint 1|Schizosaccharomyces pombe|chr 1|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • SPAC694.06c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPAC694.06c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • Mediator of replication checkpoint protein 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=mrc1 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 1019 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][TASLink to PubMed article]
    nuclear chromatin [IDALink to PubMed article]
    nuclear replication fork [TASLink to PubMed article]
    protein complex [RCALink to PubMed article]
    Biological Process: positive regulation of phosphorylation [ICLink to PubMed article]
    DNA replication checkpoint [IMPLink to PubMed article]
    regulation of catalytic activity [ICLink to PubMed article]
    intra-S DNA damage checkpoint [IDALink to PubMed article]
    Molecular Function: DNA binding [IDALink to PubMed article]
    protein binding [IPILink to PubMed articleLink to PubMed article]
    protein serine/threonine kinase activator activity [TASLink to PubMed article]
    Y-form DNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASLDENADE LHRMDSSDEA SINDDQEDIL DTPRTRVRKM LASVDMQLSS NAVSEASLDK  60
   61 ESTVGNLENQ KNRSYSSEIY LHSDTNFLSN FDSAYERVRR LLNQQGGKSS LQKKEVEQIE 120
  121 TQEGGDNAKG SPSSENKDSD RNSRLQQLIE KKRNALKKEQ EDLIQNSATS HSKSDNLDSE 180
  181 SADDSDLADE SELSKKYTSD RKIRNASKKA LLELHRNTAR LTRETALKPE VVVKKKVTLR 240
  241 EFFQKIGFKN DNQLENKAIS EEEANSTEPP NVEKEEPKPS VDRSTGIVNS EDIKELSVED 300
  301 DSLELKEITP EALDIGQTSL FTTLNQTQVK KEDNKKFLLK EINAKLNEDD IDSELEIEVK 360
  361 PKTTALDNIE KSKLSEENEH GIKGKLKQLA EIKLSKDGKP FENEFNIKSF NRNLVKRAAV 420
  421 MAKLQRNQLE EELKAKGIYK PTIQGEKEEE EDPLERARND AEKIRQLEKA SGNASDEGEL 480
  481 NDEEEVISSS NTPSTKAKTT NKVIISDVII EATQAEPKRR QKNSRVVFDE EDLTGDSHGS 540
  541 SNMKISESDD ESNGDMIRDS FDRLSSESIK DSQKTEELHD SFGINDEVDQ STSLYVQNSQ 600
  601 PSASQLTIVD ATYSQPPPRW ESSSRDDKTN TSSTQPSQVD SLVPTQLDST IPTQIDSVQR 660
  661 NKDQDDEEIL EERRESRRDS KTFLSRTMLY NKDTGKADSA WASDLIEEQA IESDDEYAGI 720
  721 GGLSDDGLSD SDAELEVQNM IDDETTIQKG EVASMAQFAK DQEMDRDEKL VKQLMKDVTT 780
  781 GALRKRNRNG FAALDDSDDE DYSNLRREKL KELRRQKLLE DGNLNVLEGD KRKAFLATVE 840
  841 DSLVSSKDNL TWLDATVEDS GVGSSDLGDE YLYSEQSLNH EEEEQMEEEL SEIFSSGGPN 900
  901 VVDRVYLKKS STRHTSDNNS LEEVLPIFPG VRKLVSNSQS EKIGDLSNDN SMGAKSYKTP 960
  961 IISSTQRPQG RKFRGLMNQS SKADISRTVD AGSIKVVPNS QSANPPRLLA SLNNYSDFD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..274] PSI-BLAST 16.0 Heavy meromyosin subfragment
    2 View Details [275..583] FFAS03 1.36 No description for 2i1jA was found.
    3 View Details [584..917] PSI-BLAST 11.69897 Tropomyosin
    4 View Details [918..1019] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle