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Protein Overview: tsc1

General Information:
Name(s) found: tsc1 / SPAC22F3.13 [Sanger Pombe]
Description(s) found:
Found 16 descriptions.
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  • hamartin [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 899 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    TSC1-TSC2 complex [IPILink to PubMed article]
    Biological Process: regulation of catalytic activity [ICLink to PubMed article]
    TOR signaling pathway [TASLink to PubMed article]
    regulation of intracellular protein transport [IMPLink to PubMed article]
    L-arginine import [IGILink to PubMed article]
    cellular response to nitrogen starvation [IMPLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]
    GTPase activator activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLQSLVKAL WNVLHEEESE GYPDLTELIA EVESYQQRYP KQNPTNSQKI RHILDEIYEK  60
   61 TPFNNTRRRI LWLAVLKTVI PLLILDRQAV GEWWDQIFFP FLNSPTQLKP VFSDLKSILF 120
  121 YILIFHDEDE WGGDLRRECA EETITRLVDL YVSKAIENLG DVESQEQRNQ TIECLVNVLV 180
  181 HYGIQRPKEL SSCFCHHFLN PPTRIPILSV MVEVIRRQGP RLYEIPQTGF YDLVLKCAEF 240
  241 DTSPILLSYA LSFILMILSH ICNSLDDSLY RLFCIYLRFS MIDPTSGFPS STASGNWEVF 300
  301 HDFMSTYAST TTSQTDSSYN DVHDIVGSSQ PDYLESLDYS QLFSILYALY PINFLEFLRD 360
  361 PKLYASKHNF QIRYSFNQEL LSTKSDGLLG RHLAHSNFLK YTAETELTDK SRWTRLDSIA 420
  421 VVALCNSLNA VGIAESVMDP FGGKLPTTYE ETSSATGLLA YPNESHDIAS EPFSISWPQN 480
  481 PSISGSVHSA TTFDKAQLSN TEDSYDNISH GTSYSEGVSS IHMVKGERGS NNLELTSESL 540
  541 SSTNDTIRRL QRDLLFLQNE LRFEKFVRQQ HLQNIGKLHR EHILDMAVES ERQKLLLTNK 600
  601 RYKAQIELLN SEIDKHRSES QAALNRRVKW ENDFNNKIKA LREEKKAWKS EESELKSSIE 660
  661 SLISQLESIR NSQIDIAFSK NQLELKLQLY ETKLKEYEQH LSCVNISKKQ VSSSSDTSFG 720
  721 NTKMDSSMIL SNSEAVSDEQ ERELIESEKH RMKLESENLH LQANIELLKK DLEAINVVYE 780
  781 AKIFDLEKRL SSEANAPELH NPVNLNYDAQ LSKISEIKEN YDELLTRYRE LEGKFLESQA 840
  841 EVEELKNFQK PLVDTGSSIH SSPGLQQSKF IIRNDSLHPK VGPPRRQSTD TSRSTFRQY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..198] deduced N/A Confident ab initio structure predictions are available.
    2 View Details [199..620] PSI-BLAST 29.154902 Heavy meromyosin subfragment
    3 View Details [621..899] PSI-BLAST 12.0 Tropomyosin


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.82

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle