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Protein Overview: trm8

General Information:
Name(s) found: trm8 / SPCPB16A4.04c [Sanger Pombe]
Description(s) found:
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  • gi|32171890|sp|Q96WV1.1|TRMB_SCHPO RecName: Full=tRNA (guanine-N(7)-)-methyltransferase; AltName: Full=tRNA(m7G46)-methyltransferase; AltName: Full=Transfer RNA methyltransferase 8 [NCBI NR]
  • gi|19075528|ref|NP_588028.1| tRNA (guanine-N7-)-methyltransferase catalytic subunit Trm8 (predicted) [Schizosaccharomyces pombe] [NCBI NR]
  • gi|14268500|emb|CAC39323.1| tRNA (guanine-N7-)-methyltransferase catalytic subunit Trm8 (predicted) [Schizosaccharomyces pombe] [NCBI NR]
  • tRNA (guanine-N7-)-methyltransferase catalytic subunit Trm8 [Sanger Pombe]
  • tRNA (guanine-N(7)-)-methyltransferase OS=Schizosaccharomyces pombe GN=trm8 PE=2 SV=1 [Swiss-Prot]
  • PUTATIVE METHYLTRANSFERASE: Q96WV1; [pompepVF.fasta]
  • PUTATIVE METHYLTRANSFERASE: CAC39323; [pompepV13]
  • Probable tRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.33) (tRNA(m7G46)-methyltransferase) [pompep4896]
  • |||putative methyltransferase [pompepnew.fasta]
  • |||methyltransferase (predicted)|Schizosaccharomyces pombe|chr 3|||Manual [pombe041504.fasta]
  • putative methyltransferase [Schizosaccharomyces pombe]gi|14268500|emb|CAC39323.1| SPCPB16A4.04c [Schizosaccharomyces pombe]gi|32171890|sp|Q96WV1|TRMB_SCHPO Probable tRNA (guanine-N(7)-)-methyltransferase (tRNA(m7G46)-methyltransferase) [nrdb_11152004_Chlamydomonas]
  • |||methyltransferase |Schizosaccharomyces pombe|chr 3|||Manual [pompep2242005.fasta]
  • (Q96WV1) Probable tRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.33) (tRNA(m7G46)-methyltransferase) [pompep4896_normal_reversed]
  • |trm8||tRNA |Schizosaccharomyces pombe|chr 3|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • Probable tRNA (guanine-N(7)-)-methyltransferase (tRNA(m7G46)-methyltransferase) [nr-271106-contam.fasta]
  • hypothetical protein SPCPB16A4.04c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • SPCPB16A4.04c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • tRNA (guanine-N(7)-)-methyltransferase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=trm8 PE=3 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 273 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][ISSLink to PubMed article]
    protein complex [ISSLink to PubMed article]
    nucleolus [IDALink to PubMed article]
    Biological Process: tRNA methylation [ISSLink to PubMed article]
    Molecular Function: tRNA (guanine-N7-)-methyltransferase activity [ISSLink to PubMed article]
    tRNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSATAKKSAA QLQREEEEAR KKLKRLSKQG GVEGRLPMKR LFRQRAHANV LSDHELEYPR  60
   61 SPSEMDWSPY YPDFDVESNK KVEIVDIGCG YGGLTVALGP QFPDTLVLGM EIRMQVSDYL 120
  121 KEKIQALRYR ADHEEPVPGG YKNISVLRMN CQKFLPNFFE KGQLSKMFFC FPDPHFKARK 180
  181 HKNRIITSTL ASEYAYFIRP HGTLYTITDV EELHVWMAQH LDAHPLFRRF TKEEEENDIC 240
  241 VTLMTNETEE GKKVARNGGK KFVACYERIP NPK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..273] PSI-BLAST 32.0 Crystal Structure of the Conserved Hypothetical Protein, Methyltransferase from Streptococcus pneumoniae TIGR4

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • methyltransferase activity
    		•  4.15445027778357 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  4.07806017452628 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  4.07153733729662 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  3.92746815303714 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  3.39429041855776 bayes_pls_golite062009
  • RNA methyltransferase activity
    		•  3.07428840534971 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  2.99461585647365 bayes_pls_golite062009
  • tRNA methyltransferase activity
    		•  2.5931020126592 bayes_pls_golite062009
  • DNA-methyltransferase activity
    		•  2.43145108778901 bayes_pls_golite062009
  • arginine N-methyltransferase activity
    		•  2.41876112831625 bayes_pls_golite062009
  • protein-arginine N-methyltransferase activity
    		•  2.41876112831625 bayes_pls_golite062009
  • rRNA methyltransferase activity
    		•  2.29640050660273 bayes_pls_golite062009
  • transferase activity
    		•  2.22303238506686 bayes_pls_golite062009
  • histone-arginine N-methyltransferase activity
    		•  2.04296107639729 bayes_pls_golite062009
  • tRNA (cytosine-5-)-methyltransferase activity
    		•  1.88889414729709 bayes_pls_golite062009
  • tRNA (cytosine)-methyltransferase activity
    		•  1.88889414729709 bayes_pls_golite062009
  • protein-arginine omega-N monomethyltransferase activity
    		•  1.66871163498737 bayes_pls_golite062009
  • tRNA (adenine-N1-)-methyltransferase activity
    		•  1.53559006858264 bayes_pls_golite062009
  • tRNA (adenine)-methyltransferase activity
    		•  1.53559006858264 bayes_pls_golite062009
  • catalytic activity
    		•  1.25333584501255 bayes_pls_golite062009
  • histone methyltransferase activity (H4-R3 specific)
    		•  1.1103522853299 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.914549843668268 bayes_pls_golite062009
  • protein-arginine omega-N asymmetric methyltransferase activity
    		•  0.89325812193225 bayes_pls_golite062009
  • DNA binding
    		•  0.86027591375666 bayes_pls_golite062009
  • rRNA (guanine) methyltransferase activity
    		•  0.720972789045101 bayes_pls_golite062009
  • site-specific DNA-methyltransferase (adenine-specific) activity
    		•  0.703178429468566 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.616949327277483 bayes_pls_golite062009
  • rRNA (adenine) methyltransferase activity
    		•  0.533090627724779 bayes_pls_golite062009
  • rRNA (adenine-N6,N6-)-dimethyltransferase activity
    		•  0.455449410561251 bayes_pls_golite062009
  • RNA binding
    		•  0.417524996559564 bayes_pls_golite062009
  • binding
    		•  0.383237930789959 bayes_pls_golite062009
  • tRNA (guanine) methyltransferase activity
    		•  0.203168546434167 bayes_pls_golite062009
  • rRNA (uridine) methyltransferase activity
    		•  0.0858581024725429 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle